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Early Active Zone Assembly in Drosophila
(2010-05-06)The dissection of presynaptic assembly processes has proven difficult in the past. Apart from genetic redundancies, this likely reflects a highly cooperative and regulated nature of synapse ... -
Early synaptic imbalance in genetic mice models of Autistic Spectrum Disorders
(2008-11-12)Autism and Rett Syndrome have been proposed to result from a dysfunction in postnatal or experience-dependent synaptic plasticity. Mice models in which selected candidate genes were mutated ... -
Ecdysone signaling and miRNA let-7 cooperate in regulating the differentiation of the germline stem cell progeny
(2015-05-06)Adult stem cells are found in most adult tissues where they are responsible for replacing cells that are lost due to turnover or injury. They have the unique ability to give rise to differentiated progeny, while at the ... -
Effects and inducers of autoantibodies against N-methyl-D-aspartate (NMDA) receptors
(2020-03-20)Autoantibodies against the IgG class of N-methy-D-aspartate-receptor subunit GluN1 (NMDAR1-AB) were believed to cause anti-NMDAR encephalitis. However, the view was chanllenged by the finding of age-dependent seroprevalance ... -
Effects of arginine derivatives and oligopeptides on the physical properties of model membranes
(2021-02-16)Cell-penetrating peptides (CPPs) are often rich in arginine. They are able to cross cell membranes and carry other molecules into cells without being cytotoxic. The mechanisms by which they accomplish this are still ... -
Effects of different energy cropping systems on plant diversity in Central German agricultural landscapes
(2015-08-17)The rich biodiversity of the Central European farmland is to a large extent directly dependent on human management decisions. Diverse and dynamic biocoenoses have developed in mutual interactions with farming practices, ... -
Effects of earthworms and tree species (Fagus sylvatica L., Fraxinus excelsior L.) on greenhouse trace gas fluxes in mixed deciduous broad-leaved forests
(2015-02-25)Despite the large number of studies and the associated knowledge gain uncertainties on the determinants of greenhouse gas fluxes from terrestrial ecosystems still exist. It is important to bridge these gaps as land use and ... -
Effects of forest structure and dynamics on vascular epiphyte assemblages - Functional trait analyses and modelling studies
(2017-04-26)Vascular epiphytes are non-parasitic plants that germinate and grow on trees without contact to the soil. Their arboreal life style implies a strong dependence on forest structure and dynamics. Tree architectures change ... -
Effects of Land Use, Habitat Fragmentation and Climate Warming on Stem Increment, Regeneration, and Hydraulic Architecture of Larix sibirica in the Mongolian Forest-Steppe
(2018-05-16)Effects of land use intensity, forest fragmentation and climate warming on stem increment and hydraulic architecture of Larix sibirica growing at the southern fringe of the Eurosiberian boreal forest in the Mongolian ... -
Effects of land-use intensity in grasslands on diversity, life-history traits and multitrophic interactions
(2012-04-25)Land-use intensification is identified as one of the major threats for biodiversity worldwide. The number of endangered species is increasing and only few species mostly generalists seem to benefit from land-use intensification. ... -
Effects of nutrient cycling through litter of different broadleaved deciduous tree species on soil biochemical properties and the dynamics of carbon and nitrogen in soil
(2013-01-30)Tree species influence soil chemical properties via the input of nutrients and protons through throughfall, stemflow, litterfall, and root respiration and/ or exudation. The effect of conifers versus hardwood trees on soil ... -
Effects of stress on the GABAergic system in the hippocampal formation and medial prefrontal cortex of the adult male rat
(2011-04-21)Stress facilitates the development of psychiatric disorders in vulnerable individuals. Previous studies have well documented the impact of stress on glutamatergic excitatory transmission ... -
Effects of temperature and body mass on soil communities
(2013-01-11)The Earth is undergoing a climate change with predicted increases in temperature by up to 6° C until 2100. How this warming affects soil food webs is of fundamental interest for mankind as it may influence global food ... -
Effects of α/β/γ-Synuclein overexpression on the mitochondria and viability of neurons, examined using genetically encoded fluorescent sensors
(2014-09-25)Parkinson’s disease (PD) is the second most common neurodegenerative disease and it affects more than 1% of the worlds population over the age of 65. A hallmark of PD is the appearance of Lewy bodies (LBs) throughout the ... -
Electrical Control of Droplet formation in Microfluidic Devices
(2014-09-23)This thesis presents both experimental investigations and demonstration on the use of an AC voltage induced electric field to actively control the size or frequencies of droplet generated in a microfluidic flow focusing ... -
Electrocutaneous stimulation to close the loop in myoelectric prosthesis control
(2017-08-09)Current commercially available prosthetic systems still lack sensory feedback and amputees are forced to maintain eye-contact with the prosthesis when interacting with their environment. Electrocutaneous stimulation is a ... -
Electrophysiological Analysis of the Synaptic Vesicle Priming Process
(2017-08-17)Chemical synaptic transmission is the most prominent communication channel employed by neural circuits. It is initiated by the action potential triggered fusion of transmitter-filled synaptic vesicles with the presynaptic ... -
Elongation factor P: mechanism of action and opportunities for drug design
(2023-07-24)EF-P is a conserved protein that has shape similarity to the tRNAs and binds to the E site of the ribosome. EF-P enhances the rate of peptide bond formation during the synthesis of polyPro sequences. In E. coli one third ... -
Elucidating the mechanisms of disease-triggering myelin-specific autoantibodies
(2019-10-24)Although T cells are commonly known to be the driving force of disease pathogenesis in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), B cells and their soluble effector molecules ... -
Endocrine control of T cell function and its implications for the pathogenesis of neuroinflammatory diseases
(2013-06-17)Insulin and GCs are two important endocrine regulators of mammalian body homeostasis and both impact on immune cell functions. Whereas GCs are in widespread use for the treatment of autoimmune diseases since the late 1950s, ...