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Targeted secretion and remodelling of pectin in response to pathogen infection
(2020-04-02)Plant cell walls are a complex mix of three major classes of polysaccharides; cellulose, hemicellulose and pectin together with a minor amount of proteins, and they surround every plant cell. Besides serving as a structural ... -
Targeting ion sensors to synaptic vesicles using a Nanobody against luminal Synaptotagmin 1
(2022-02-24)The synapse is a specialized nanostructure that connects two neurons where the ionic composition in each of its nano compartments is the driving process for synaptic transmission. Synaptic transmission relies on the ... -
Targeting microglial CSF1R in health and disease
(2021-09-03)The main effector functions of microglia are immune, synaptic network refinement, brain insult reaction, and neurogenesis regulation. This cumulative doctoral thesis focuses on the relevance of the colony-stimulating factor ... -
Taxonomy and Phylogeny of Leaf Monkeys (Colobinae) with Focus on the Genus Presbytis (Eschscholtz, 1821)
(2012-08-07)Leaf monkeys (Colobinea) constitute a very diverse group of primates with major radiations inAfrica and Asia. Among the langur group, Presbytis constitutes a particular diverse taxon. Based on molecular biological and ... -
Taxonomy and Phylogeny of the Liverwort Genus Thysananthus (Marchantiophyta; Lejeuneaceae)
(2011-06-23)A systematic study of the liverwort genus Thysananthus, especially the subgenus Thysananthus, based on the results of morphological-anatomical, phytochemical and molecular phylogenetic ... -
Taxonomy, phylogeny and distribution of tamarins (genus Saguinus, Hoffannsegg 1807)
(2012-01-09)The Callitrichinae are small bodied New World primates, including two of the most diverse groups of primates, the marmosets (genera Callithrix and Mico) and tamarins (genus Sa-guinus). So ... -
Temporal information processing and memory guided behaviors with recurrent neural networks
(2015-02-25)The ability to quantify temporal information on the scale of hundreds of milliseconds is critical towards the processing of complex sensory and motor patterns. However, the nature of neural mechanisms for temporal information ... -
Terrestrial laser scanning- applications in forest ecological research
(2011-02-24)The increasing relevance of the three-dimensional (3D) structure of forest canopies for current research tasks, especially in ecology, generates a rising need for instruments offering ... -
Thalamocortical Innervation of GABAergic Interneurons in Mouse Primary Vibrissal Somatosensory Cortex
(2020-11-26)Interneurons utilizing gamma-aminobutyric acid (GABA) as primary neurotransmitter are thought to play a key role in neocortical processing. Their striking diversity has been in focus of numerous studies for decades. However, ... -
The 5XFAD mouse model: a tool for genetic modulation of Alzheime's disease pathology
(2012-01-25)AD mouse models contributed widely to our understanding of the pathophysiology of AD and represent invaluable tools in testing potential therapeutic interventions. In the present study, ... -
The accumulation of mutant p53 in human cancer cells
(2011-07-04)The tumor suppressor p53 is mutated in more than 50% of all human solid tumors. This comprises mostly single residue missense point mutations that entail a loss of p53 tumor suppressor ... -
The Advantages Of Paramagnetic NMR
(2013-11-28)There are three distinct effects in nuclear magnetic resonance spectroscopy (NMR) that differ between paramagnetic and diamagnetic molecules in isotropic solution. These are residual dipolar coupling (RDC), pseudocontact ... -
The Aspergillus fumigatus Vap-Vip methyltransferase pathway modulates stress response, secondary metabolism and azole resistance
(2019-07-11)The VapA-VapB-VipC trimeric complex is part of an epigenetic developmental control pathway of A. nidulans. VeA-interacting protein (VipC) and VipC-associated protein B (VapB) are methyltransferases, and VapA is a zinc-finger ... -
The assembly of island floras from a macroecological perspective.
(2019-01-24)Islands have always played a central role in ecology and biogeography. On the one hand, island biotas are ecologically unique by featuring exceptionally high rates of endemism and remarkable evolutionary adaptations while ... -
The Cellular Function of USP22 and its Role in Tissue Maintenance and Tumor Formation
(2018-02-12)Colorectal cancer (CRC) is the most frequent malignancy of the gastrointestinal tract and therefore reflects a global health issue. Despite improved detection and treatment options the high mortality and morbidity rates ... -
The client spectrum of Get3, an evolutionarily conserved chaperone of membrane proteins
(2020-03-12)Tail-anchored proteins constitute a physiologically important class of membrane proteins. Due to their topology, they are targeted post-translationally to membranes. Although Get3 is responsible for the membrane targeting ... -
The Coalescent in Boundary-Limited Range Expansions
(2014-10-14)Habitat ranges of most species shift over time, for instance due to climate change, human intervention, or adaptation. These demographic changes often have drastic effects on the genetic composition of the population, ... -
The confused flour beetle, Tribolium confusum A model for investigating Wolbachia-host interactions
(2022-07-20)Summary Wolbachia, a group of maternally inherited intracellular endosymbiotic Alphaproteobacteria, are found in a wide range of arthropods and nematodes. It has been estimated that over 65% of insect species are infected ... -
The contribution of N-terminally modified amyloid beta to the etiology of Alzheimer's disease
(2012-09-07)A heterogeneou s mixture of amyloid beta (Aβ) isoforms exists in the brains of Alzheimer's disease (AD) patients. Despite decades of research, relatively little is known about the precise contribution of these variousAβ ... -
The contribution of oligodendrocytes to amyloid and tau pathologies in mouse models of Alzheimer’s disease
(2024-03-18)Oligodendrocytes (OLs) are the myelinating glia of the CNS and are capable of metabolically supporting long axonal projections by providing local fuel production. OL and myelin health, however, start degrading around the ...