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Ultrafast Multichannel Optogenetic Stimulation of the Auditory Pathway for Optical Cochlear Implants
(2019-01-14)In case of profound sensorineural hearing loss and deafness, cochlear implants (CIs) partially restore hearing and provide missing auditory information to the brain. Electrical stimulation of the spiral ganglion neurons ... -
Ultrastructural Characterization of The Output of VIP Expressing Interneurons in Mouse Barrel Cortex
(2017-11-15)Based on this preliminary result, a quantitative immunoelectron microscopy study was adopted to comprehensively characterize the output of VIP interneurons across the whole laminae of mouse barrel cortex. Using VIPcre/YFP ... -
Ultrastructural study of synaptic vesicle dynamics in murine inner hair cell ribbon synapses under sustained stimulation
(2023-07-11)Transmission of auditory information relies in the correct functioning of inner hair cell (IHC) rib-bon synapses, which mediate synaptic vesicle release in an indefatigable manner. The name-giving synaptic ribbon and the ... -
Undersampled Radial STEAM MRI: Methodological Developments and Applications
(2018-03-09)The diffusion-weighted (DW) single-shot stimulated echo acquisition mode (STEAM) sequence offers DW MRI without susceptibility artifacts which severely hamper diagnostic applications when using conventional echo-planar ... -
Understanding Nucleosome Assembly Regulation in Drosophila melanogaster
(2022-06-24)Nucleosomes consist of a complex of DNA and an octameric core of histone proteins, which represent the basic subunit of chromatin. The N-terminal tails of histones are target for chemical modifications, which play an ... -
Universal Computation and Memory by Neural Switching
(2011-10-21)Complex heteroclinic networks of connected saddle states persistently emerge in a broad range of dynamical systems and may reliably encode ``memory items'' as specific switching trajectories. ... -
Unraveling details of CIN85/CD2AP assistance to SLP65-mediated B cell activation
(2020-06-18)The hallmark of adaptive immunity is the production of specific antibodies. This process is initiated upon the ligation of the B cell antigen receptor (BCR) which activates multiple intracellular signaling cascades through ... -
Unraveling the Role of TET3 in regulating EndMT in Cardiac Fibrosis
(2023-02-10)DNA methylation and subsequent silencing of gene expression is associated with disease states including tumorigenesis and fibrosis. Although DNA methylation is a dynamic and reversible process, the mechanisms of and ... -
Unravelling the Role Cortical Myelination Plays in Higher Brain Functions
(2021-07-07)Myelination is a process within the nervous system, where axons are ensheathed by lipid-rich, multi-spiral wraps called myelin. Its main role is to expedite impulse propagation within circuitries and allow for faster ... -
Untangling neuronal diversity: a quantitative electrophysiological and morphological characterization of VIP expressing interneurons
(2017-03-21)VIP expressing interneurons are an essential component of cortical circuitry. This distinct subgroup of inhibitory interneurons was always described as the most heterogeneous subgroup of inhibitory interneurons. However, ... -
Untersuchung des TGF-β-induzierten Zelltods in oligodendroglialen Kulturen
(2008-02-12)Apoptosis is controlled by complex networks with various interactions between different signalling pathways regarding to extracellular as well as intracellular signals. Thereby, the transforming growth factor (TGF)-β ... -
Untersuchungen zur Funktion der Gene MPH1 und MMS2 aus Saccharomyces cerevisiae bei der fehlerfreien Umgehung von replikationsarretierenden DNA-Schäden
(2010-02-25)in vivo error free bypass of replication blocking lesions is done by at least two distinct processes: homologous recombination via sister chromatid interaction (SCI) and post replicative repair (PRR). Additionally PRR is ... -
Untersuchungen zur Wirksamkeit von Dacarbazin und Temozolomid bei der Behandlung des kutanen Melanoms in Assoziation mit DNA-Reparatur
(2010-02-09)The aim of this study was to identify individual host markers for hematologic side effects and treatment efficacy of dacarbazine or temozolomide in melanoma treatment. Such markers could facilitate the decision for or ... -
USPL1, a novel SUMO isopeptidase
(2009-06-23)Small Ubiquitin-like Modifiers (SUMO) are 10 kDa proteins that are covalently attached to hundreds of intracellular proteins to regulate their function. In mammals, three members of the ... -
Validation of novel protein-protein interactions in Bacillus subtilis
(2023-01-12)Protein-protein interactions are the basis for many biological processes in the cell. Understanding these interactions is crucial for the general analysis of how the cell functions and the potential identification of ... -
Vav guanine nucleotide exchange factors control B cell antigen receptor-induced Ca2+-signaling
(2016-03-15)Differentiation of B cells into antibody secreting plasma cells is an indispensable step to cope with pathogens. Antigen binding to the B cell antigen receptor (BCR) initiates signaling cascades leading in combination with ... -
Vegetation dynamics of the East- European forest-steppe since the Late Glacial: climate, human and fire impact
(2024-03-11)While many studies have documented changes of the northern latitudinal forest limit in Europe and its drivers, little is known about the southern latitudinal limit of the forest towards the steppe in Eastern Europe. ... -
Vegetation patterns and processes in semi-natural open habitats and the contribution of wild red deer to their conservation
(2019-09-30)Traditional practices of human land use have shaped semi-natural open habitats over the past millennia, resulting in the typical European cultural landscapes with characteristic, diverse species communities. In the course ... -
Vegetation, climate and fire dynamics of Upper Montane Forest and Campos de Altitude during the Holocene in southeastern Brazil
(2020-09-22)The Atlantic Forest biome is well known as one of the mostly biodiversity regions on earth, hosting high species endemism and species/area ratio. It stretches around 1,300,000 km2 along the Brazilian coast between latitudes ... -
Vergleichende Untersuchungen zur Regulation der SNARE-Komplexbildung durch Sec1/Munc18-Proteine
(2009-07-01)Membrane fusion events between various intracellular compartments in eukaryotic cells are mediated by two conserved protein families: SNARE- and Sec1/Munc18 (SM)-proteins. The SNARE ...