Browsing Human- und Zahnmedizin by Referee "Beißbarth, Tim Prof. Dr."
Now showing items 1-20 of 21
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Postprozeduraler Blutdruck nach kathetergestütztem Aortenklappenersatz (TAVI) als prognostischer Parameter für das Ein-Jahres-Überleben
(2023-07-17)Background Arterial hypertension is a common comorbidity in patients with aortic stenosis. Regarding blood pressure targets after transcatheter aortic valve replacement (TAVR) prior studies show conflicting results. As ... -
Genome-wide association studies and follow-up kernel approaches in the longitudinal PsyCourse Study
(2023-02-23)A genetic association study is a popular method to analyse the connection of genomic factors with disorders or disease-related phenotypes. There are various study types including genome-wide association studies (GWASs) and ... -
Association Analysis Using Set-Based Approaches in the Post-GWAS Era
(2021-08-10)Genotyping arrays have greatly facilitated genetic epidemiological studies into genetic risk factors for numerous complex diseases such as psychiatric disorders. The use of genome-wide association analysis (GWAS) is ... -
Genetische Polymorphismen in Typ-III-Interferon-Genen und deren prognostische Signifikanz für das hepatozelluläre Karzinom und das duktale Pankreasadenokarzinom
(2021-03-08)Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are malignancies with a leading lethality. With reference to interferons (IFNs) known to mediate antitumor activities, this study investigated the ... -
Analyse der Genexpression von humanen Stro-1-positiven Zahnkeim- und Beckenkammzellen in DME-Medium und osteogenem Differenzierungsmedium
(2020-08-18)Because of the ethically controversial use of embryonic stem cells in tissue engineering there has been an increased interest in mesenchymal stem cells, which can be found in various adult tissues. The present study ... -
Epigenetische Suppression von RASAL1 und ATP2A2 als Biomarker und Therapieansatz bei kardialer Fibrogenese
(2020-07-10)Chronic heart diseas constitutes a growing medical challenge on a global scale. It is associated with cardiac fibrosis - the accumulation of extracellular matrix produced by persistently activated fibroblasts. Epigenetic ... -
Erweiterte Charakterisierung substratspezifischer Effekte genetischer Polymorphismen im organischen Kationentransporter OCT1
(2019-10-09)The human organic cation transporter 1 (OCT1) mediating the hepatic uptake of drugs and cationic substances shows high genetic variability. About 9% of the population are carriers of two inactive OCT1 alleles (poor OCT1 ... -
Lehrqualität in der universitären Medizin
(2019-05-08)Background: In undergraduate medical education, teaching quality needs to meet high standards because teaching represents a fundamental component in the training of future physicians. For this, student ratings of teaching ... -
Sekundärprävention und stationärer Verlauf von Patienten mit koronarer Herzerkrankung zwei Jahre nach stationärer Anschlussheilbehandlung
(2018-10-18)BACKGROUND The recently published EUROASPIRE IV study demonstrated that a large majority of coronary patients do not achieve the guideline standards for secondary prevention. High prevalences of persistent smoking, unhealthy ... -
Immunhistochemische Analyse der p16-Expression im Rektumkarzinom: Vergleich von Patienten mit und ohne neoadjuvante Radiochemotherapie
(2018-05-29)Background: In Germany the standard treatment of locally advanced adenocarcinoma within the first 12cm of the rectum is a neoadjuvant radiochemotherapy (RCT) followed by a total mesorectal excision (TME) and adjuvant ... -
Epigenetische DNS-Modifikation von Campylobacter coli
(2018-03-15)Campylobacter species are the most prevalent pathogen causing acute bacterial enteritis worldwide. In contrast to Campylobacter jejuni, about 15% of Campylobacter coli strains exhibit susceptibility to restriction endonuclease ... -
Kernel-Based Pathway Approaches for Testing and Selection
(2017-10-12)With the number of single nucleotide polymorphisms (SNPs) available in genetic data currently constantly increasing, the evaluation of SNP sets has become a successful approach toward elucidating the genetic influence on ... -
Analyse von Interleukin-10-Genvariationen bei diffus großzelligen B-Zell-Lymphomen
(2016-09-12)Although Non-Hodgkin lymphoma principally can be cured due to current therapy strategies some patients do not achieve complete remission. Besides many patients are affected by significant therapy-related toxicities. In ... -
Analyse der differentiellen Genexpression von humanen Stro1-positiven Zellen aus pulpalem Zahnkeimgewebe und Beckenkammspongiosa
(2016-06-20)The discovery of adult dental stem cells established a new field of research with regard to the regeneration of dental tissues. To date only few studies compared the gene expression profiles of dental pulp and bone marrow ... -
Genomic variations in the EGFR pathway in relation to skin toxicity of EGFR inhibitors analyzed by deep sequencing
(2015-04-08)The development of targeted therapy has promised a new era in cancer therapy by improving response rates and fewer side effects of the therapeutics on normal cells. As the involvement of EGFR was noticed in several epithelial ... -
Identifizierung genetischer Biomarker für die Wirksamkeit von Oxaliplatin:Kandidatengen-bezogene und Genom-weite Analysen
(2014-11-28)Oxaliplatin is an anticancer drug used to treat advanced and metastatic stages of colorectal carcinoma. In patients, different treatment responses can be observed suggesting an impact of germline genetic variability. ... -
Gene-Environment Interaction and Extension to Empirical Hierarchical Bayes Models in Genome-Wide Association Studies
(2014-07-24)There are over 100,000 human diseases of which only around 10,000 are known to be monogenic, resulting from modification in a single gene. Many multifactorial diseases, such as cancer and lung cancer in particular, are ... -
Die Rolle von Zytokin- und Zytokinrezeptorgenvariationen für die Ausprägung von GvHD und GvL nach allogener Blutstammzelltransplantation bei Patienten mit hämatologischer Neoplasie
(2014-02-17)Many publications show the influence of cytokine-gene-variations on the development of Graft versus Host disease. I studied the influence of cytokine-gene- and cytokine-receptor-gene-variations of the IL 10 gene on the ... -
Functional Assessment of Biomarkers in Gemcitabine-Treated Pancreatic Cancer with Specific Focus on Nucleoside Transporter ENT1
(2013-10-31)Pancreatic ductal adenocarcinomas are the fourth leading cause of death among all kinds of cancers. The poor prognosis is due to usually late diagnosis and, in most cases, the available therapeutic options lack sustained ... -
Individualisierte Microarrayanalyse von PDL-Gewebe von Patienten mit Parodontitis
(2011-11-07)This dissertation deals with the different gene expression patterns between healthy and chronically diseased PDL using microarray analysis and real-time (RT)-PCR. The genes studied in this ...