Dokumente Human- und Zahnmedizin nach Gutachter "Binder, Claudia Prof. Dr."
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Charakterisierung und Bedeutung extrazellulärer Vesikel im Blut von Patienten mit soliden Tumoren
(2023-07-18)The goal of the study was to analyse tumour-associated extracellular vesicles in the blood of patients with solid tumour diseases and their connection with the clinical progress of the diseases. The vesicles of 330 ... -
Neural progenitor cell-derived extracellular vesicles enhance blood-brain barrier integrity in stroke mice
(2022-04-28)Objective Extracellular vesicles (EVs) derived from neural progenitor cells (NPCs) enhance post-stroke neurological recovery, albeit the underlying mechanisms remain elusive. Since previous research described an enhanced ... -
Diagnostische und funktionelle Relevanz neutraler Sphingomyelinasen bei der Sekretion extrazellulärer Vesikel aus Prostatakarzinomzellen
(2022-02-01)The prostate carcinoma is the most common malignant tumour disease in men. Despite good early detection and treatment options, prostate carcinoma remains the second most common cause of tumour-related death in Germany. ... -
Einfluss der sauren und der neutralen Sphingomyelinasen auf Produktion und Zusammensetzung extrazellulärer Vesikel von Mamma-Karzinom-Zelllinien
(2021-07-06)Extracellular vesicles, including microvesicles and exosomes, are important mediators in cell-cell-communication, both in physiological and pathological processes. Due to their diagnostic and therapeutic potential they ... -
Prediction of patients’ response to immune checkpoint inhibitors in the treatment of advanced NSCLC
(2021-02-12)Lung cancer is one of the most frequently occurring malignancies at the present time and still the leading cause of cancer deaths worldwide. Checkpoint pathway inhibitors are a family of cancer immunotherapy that has been ... -
Expression von Genen des WNT-Signalwegs in humanen Makrophagen nach MCF-7 Ko-Kultivierung und in murinen Makrophagen nach Mikrovesikel-Stimulation
(2019-09-19)The interaction between malignant cells and stroma cells contributes in a crucial way to their biological activity. In breast cancer there is an association between activation of the canonical WNT-Pathway and aggressive ... -
Proliferationsuntersuchungen zur Entwicklung des Lymphgefäßsystems bei Wnt5a-transgenen Mäusen
(2018-04-27)Wnt5a is a secreted glycoprotein and represents one of the 19 members of the human WNT-gene-family, which regulate embryonic development. In contrast to most other members of the Wnt-family, Wnt5a also is a regulator of ... -
Prädiktive Biomarker für die Entwicklung von high grade acute organ toxicity im Rahmen der Radiochemotherapie bei Patienten mit Kopf-Hals-Tumoren
(2017-11-22)The treatment of head and neck cancers by radiochemotherapy often leads to high grade acute organ toxicity (HGAOT). These side effects impair the patients’ quality of life as well as the local tumor control as they can ... -
Die Analyse der Neoangiogenese anhand des Vergleichs der CD31-und PEDF-Expression im vitalen Gewebe des Adeno-und Plattenepithelkarzinoms der Lunge
(2016-12-13)Lung cancer is the leading cause of death worldwide and effective therapeutic approaches are largely lacking. This study focusses on neoangigenesis that is a potential therapeutic target in this disease. The aim was to ... -
Einfluss von ERß-Agonisten auf Wachstum und Invasion von triple-negativen Mammakarzinomzellen
(2015-11-02)Metastasis to bone is a frequent problem of advanced breast cancer. Particularly breast cancers, which do not express estrogen receptor α (ERα) and progesterone receptor (PR) and which have no overexpression of human ... -
Patienten mit hämatologischen Grunderkrankungen in der Palliativversorgung
(2015-06-22)Background: Patients with hematological malignancies are underrepresented in specialised palliative care institutions as compared to patients with solid tumours. When palliative care interventions do take place, they occur ... -
Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy
(2014-09-25)A considerable percentage of rectal cancers are resistant to standard preoperative chemoradiotherapy. Because patients with a priori-resistant tumors do not benefit from multimodal treatment, understanding and overcoming ... -
Kisspeptin-10 - ein potenzieller Inhibitor der Invasion humaner Endometriumkarzinomzellen
(2014-02-24)Objectives: The cross talk between metastatic cancer cells and target sites is critical for the development and progression of metastases. Disruption of this interaction will allow to design mechanism-based effective and ... -
Lebensqualität pflegender Angehöriger in der Sterbephase von Krebspatienten: Vergleich zwischen einer Palliativstation und häuslicher Versorgung
(2013-06-06)Background: Not much is known about quality of life of caregivers of dying relatives in Germany. Methods: The survey was carried out at the palliative care unit of the Centre for Anaesthesiology, Emergency and Intensive ... -
Etablierung der Organotypischen Hirnschnitt-Kokultur als Tumor-Invasionsmodell
(2013-02-12)The aim of this study is to contribute significantly to our understanding of cerebral metastasis formation. The process of the metastatic site has barely been investigated yet, in particular the role of resident cells. It ... -
Effects of Wnt and different TLR stimulations on microglia-induced invasion of breast cancer cells
(2012-10-31)The role of the benign microenvironment in the primary tumor has recently come into focus. In particular, research has shown that blood-derived macrophages may support tumor progression. By contrast, the role of resident ... -
Tumorspezifische Substanzen zur Symptomkontrolle in der Palliativmedizin - Entscheidungsfindung und Anwendung
(2012-05-30)Since the mid-1990s it has been assumed that tumor-modifying substances such as chemotherapeutics and – later on – so-called Targeted Therapies have positive effects on the control of symptoms and the life quality of ... -
Investigation of TRAIL resistance in ovarian cancer cell lines and translational application in primary ovarian cancer cells
(2011-09-21)Ovarian cancer, the deadliest of the gynaecologic malignancies, poses a therapeutic challenge because of the 70% recurrence rate among patients treated with taxane/platinum-based chemotherapy. ... -
Einfluss von Kisspeptin-10 auf die knochengerichtete Migration und Invasion von Mammakarzinomzellen
(2011-06-01)Metastases in the bone are a frequent problem in advanced breast cancer since the morbidity of the individual patient is increasing which is on the other hand decreasing their quality of ... -
Tumorspezifische Therapien in der Palliativmedizin
(2010-11-09)Anticancer therapies (ACT) gain increasing attention and discussion in specialized palliative care institutions. Frequency, indication, mode of therapy, attitude of team members, and clinical ...