Browsing Human- und Zahnmedizin by Referee "Brockmöller, Jürgen Prof. Dr."
Now showing items 1-20 of 29
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Bedeutung von Genvarianten im organischen Kationentransporter 1 (OCT1) für Pharmakokinetik, Wirkungen und Nebenwirkungen des Antidepressivums Amitriptylin und dessen Metaboliten Nortriptylin
(2024-07-09)Efficacy and side effects of amitriptyline and nortriptyline vary greatly between patients. Interindividual pharmacokinetic variability may be based on genetic polymorphisms in the drug metabolizing enzymes CYP2C19 and ... -
Automated Metadata Transformation in a Medical Data Integration Center: Implementation of an Algorithm and Standardized Quality Analysis
(2023-11-02)Evidence-based medicine is the conscientious, explicit, and judicious use of the current best scientific evidence to make informed decisions about the medical care of individual patients. The practice of evidence-based ... -
Die ethische Problematik von Scheinoperationen in der medizinischen Forschung
(2023-08-08)The publication was about to analyze the ethical problems arrising from sham surgerys. There have been some examples in liturature that show that sham surgeries or sham treatment have been performed in several studies. The ... -
Nephrotoxizität bei immunsuppressiver Therapie nach Lebertransplantation Ein systematischer Review und Metaanalyse
(2022-11-22)It is known that calcineurin inhibitors (CNI), tacrolimus and cyclosporine have acute and chronic nephrotoxic effects. Liver transplant recipients get CNI after transplantation. Therefore, are used to spare CNI other ... -
Der Umgang von Gesundheits- und Krankenpflegeschülern mit Benzodiazepinen und Z-Substanzen im Krankenhaus – Ergebnisse von Gruppendiskussionen
(2021-10-01)The use of benzodiazepines and Z-drugs for difficulties in falling asleep and staying asleep at the hospital increases the risk for inappropriate sedation, falls and fractures. The issue of the proper use of these ... -
Antibiotikaverbrauch in der medizinischen Versorgung von Geflüchteten
(2021-04-22)Unnecessary and inappropriate use of antibiotics is a widespread problem in primary care. However, current data on the care of refugees and migrants in initial reception centers is pending. This dissertertion provides ... -
Hypnotika auf Privatrezept auch für Kassenpatienten
(2019-09-20)Background: In the ambulatory care setting, the number of hypnotic and sedative prescriptions covered by statutory health insurance has significantly decreased over the last decades. However, benzodiazepines and Z-drugs ... -
Bedeutung genetischer Polymorphismen im organischen Kationentransporter OCT1 für die Pharmakokinetik und Nebenwirkungen von Proguanil
(2019-01-22)Currently, only limited data exists regarding organic cation transporter OCT1 in the context of polymorphisms in drug transporters and their impact on pharmacokinetics of drugs in humans. In vitro experiments showed that ... -
Psychopharmakologische Behandlung stationärer Patienten mit somatoformen Störungen - Veränderungen über die letzten zwei Jahrzehnte
(2018-02-20)This study aimed at investigating characteristics of the pharmacological treatment of patients with somatoform disorders on the long-term in the interval between 2005 and 2012. Respective variables, before all psychotropic ... -
Bedeutung genetischer Varianten für das Auftreten von Herzrhythmusstörungen bei Patienten mit intrakardialem Kardioverter-Defibrillator: Eine Pilotstudie zu kardiologisch relevanten Surrogatmarkern und Prädiktoren von Herzrhythmusstörungen
(2016-11-11)Sudden cardiac death (SCD) due to caradiac arrhythmias is a major complication in patients with cardiac disease. However risc stratification is improvable as life-threatening cardiac arrhythmias do not occur in many patients ... -
Stellenwert des Opioidantagonisten Naltrexon bei stationär behandelten Borderline-Patienten
(2016-09-23)Introduction: Although 85% of inpatients with Borderline Personality Disorder (BPD) receive psychotropic drug treatment, no drug is approved for this indication so far. A dysregulation of the endogenous opioid system ... -
Einfluss des eNOS T-786C-Polymorphismus auf die 5-Jahres-Mortalität und -Morbidität von Patienten nach herzchirurgischen Eingriffen
(2015-04-13)Nitric oxide (NO) is an endothelium-derived relaxing factor (EDRF) which represents one of the most relevant molecules involved in biological systems. NO is produced by three nitric oxide synthase (NOS) isoforms: neuronal ... -
Genomic variations in the EGFR pathway in relation to skin toxicity of EGFR inhibitors analyzed by deep sequencing
(2015-04-08)The development of targeted therapy has promised a new era in cancer therapy by improving response rates and fewer side effects of the therapeutics on normal cells. As the involvement of EGFR was noticed in several epithelial ... -
Einfluss des eNOS-G-894-T-Polymorphismus auf die 5-Jahres-Mortalität und-Morbidität kardiochirurgischer Patienten
(2015-03-25)Nitric oxide (NO), an endothelium-derived relaxing factor (EDRF), plays a crucial role in regulating the mammalian cardiovascular system. The endothelial NO Synthase (eNOS) is a key enzyme that synthesizes NO from L-Arginin. ... -
Identifizierung genetischer Biomarker für die Wirksamkeit von Oxaliplatin:Kandidatengen-bezogene und Genom-weite Analysen
(2014-11-28)Oxaliplatin is an anticancer drug used to treat advanced and metastatic stages of colorectal carcinoma. In patients, different treatment responses can be observed suggesting an impact of germline genetic variability. ... -
Bedeutung genetischer Polymorphismen im Beta-1-Adrenorezeptor für die Wirkungen von Metoprolol und Carvedilol
(2014-08-08)Beta blockers are some of the most-prescribed medications in modern medicine regarding cardiovascular diseases. Their main molecular target ist the beta-1-adrenoceptor, a seven transmembrane helical proteine, belonging to ... -
Functional Assessment of Biomarkers in Gemcitabine-Treated Pancreatic Cancer with Specific Focus on Nucleoside Transporter ENT1
(2013-10-31)Pancreatic ductal adenocarcinomas are the fourth leading cause of death among all kinds of cancers. The poor prognosis is due to usually late diagnosis and, in most cases, the available therapeutic options lack sustained ... -
Clinical, functional, and genetic analysis of NER defective patients and characterization of five novel XPG mutations
(2013-02-12)Abstract Xeroderma pigmentosum (XP), Trichothiodystrophy (TTD), and Cockayne Syndrome (CS) are rare (incidence ~1 to 1 million) recessively inherited genetic diseases arising from genetic defects in the nucleotide excision ... -
Transcriptional regulation of sex-dependently expressed renal organic anion transporter 1 and 3
(2013-02-11)The renal organic anion transporters (OATs) play a pivotal role in the elimination of endogenous and exogenous substrates. In rats, an often used preclinical animal model, the basolateral located organic anion transporter ... -
Genetisch bedingte Variabilität der Expression von Genen des TGFß-Signalwegs und deren Bedeutung für die Zellvitalität: Untersuchungen in T-Lymphozyten, immortalisierten B-Lymphozyten und Fibroblasten
(2013-01-29)The TGFbeta pathway is involved in a huge number of biological functions and, hence, relevant for a plethora of clinical disorders. A major function of this pathway is its contribution to fibrotic conditions as it may ...