Dokumente Human- und Zahnmedizin nach Gutachter "Jakobs, Stefan Prof. Dr."
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Analyse funktioneller und struktureller Mitochondrienveränderungen in einem Maus-Modell für das Rett-Syndrom mittels 2-Photonen-Mikroskopie
(2017-01-09)Rett syndrome is a neurodevelopmental disorder that is caused by de novo mutations in the X-chromosomal MECP2 gene which encodes for the transcriptional modulator methyl CpG binding protein 2 (MeCP2). Almost girls are being ... -
Die anaplastische Lymphomkinase (ALK) im Fokus der genomischen Instabilität des Neuroblastoms: Funktionale und morphometrische Untersuchungen
(2020-11-13)Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the family of insulin receptors. It is considered to be a potential driver for the development of neuroblastoma, a complex and often therapy-resistant ... -
Evaluation des Antwortverhaltens des genetisch kodierten optischen Redox-Indikators HyPer
(2020-07-07)Oxygen radicals, also known as reactive oxygen species (ROS), play a significant role in neurological diseases and in cell communication. Therefore, there is a tremendous interest in monitoring (sub)cellular redox conditions. ... -
Expansionsmikroskopie des Rattenhirns zur subzellulären Lokalisation synaptischer Proteine
(2022-01-26)The basis and drive for the implementation of the present work was the desire for a more precise understanding of the subcellular distribution and quantity of presynaptic proteins in presynapses of different brain regions. ... -
Funktionelles ROS/Redox Imaging, basierend auf genetisch-kodierten optischen Sensoren, exzitationsratiometrischer Zwei-Photonen-Mikroskopie und Fluoreszenzlebenszeiten
(2019-06-20)Reactive oxygen species (ROS) contribute to cellular signaling and neuropathology. There is tremendous interest in quantitative recordings of their celluar dynamics. Previously, organic dyes served to rate ROS formation ... -
Mitochondriale Dynamik und Funktion in der Muskelentzündung
(2021-09-30)In muscle biopsies of patients with inclusion body myositis signs of degeneration, inflammation and mitochondrial damage can be detected. Pathogenesis of this neuromuscular disorder, predominantly affecting elderly male ... -
Quantitative mikroskopische Analyse der Regulationsmechanismen der Anaplastic Lymphoma Kinase in Neuroblastomzellen
(2020-01-09)The anaplastic lymphoma kinase (ALK) plays an essential role in the pathogenesis of neuroblastoma. While the structure of the ALK-receptor as well as point mutations within the primary amino acid sequence of the receptor ... -
Schichtenspezifische Charakterisierung der VIPcre/tdTomato-Mauslinie mittels neurochemischer Marker
(2015-07-28)The neurons of the neocortex can be subdivided into excitatory and inhibitory neurons. The inhibitory neurons, which make up 20-30% of the neurons are GABAergic interneurons, which can be distinguished by morphological, ... -
Spektrale Eigenschaften des intrinsischen optischen Signals während hypoxieinduzierter Spreading Depression im Hippokampus der Ratte
(2011-06-29)Intinsic optical signals (IOS) regularly occur together with hypoxia induced spreading depression (HSD). IOS show a characteristic developement. First tissue reflectance becomes a little ... -
Transgene Redoxindikator-Mäuse mit mitochondrialer roGFP1-Expression: Phänotypisierung, neuronales Verteilungsmuster und Sensorfunktionalität
(2017-12-05)Reactive oxygen spezies (ROS) and redox alterations determine not only physiological signaling but also lead to oxidative stress, cellular dysfunction and a wide range of pathologies. A major source of ROS-generation is ...