Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Fritz, Hans-Joachim Prof. Dr."
Anzeige 21-36 von 36
-
Isolation and Characterization of Human Precatalytic Spliceosomal B Complexes
(2007-04-26)The spliceosomal B complex is the substrate that undergoes catalytic activation leading to catalysis of pre-mRNA splicing. Previous characterization of this complex was performed in the ... -
Molecular Characterization of pFGE, the Paralog of the C-α-Formylglycine-generating Enzyme
(2006-03-01)C-α formylglycine (FGly) is the catalytic residue in the active site of sulfatases. In eukaryotes, it is generated in the endoplasmic reticulum by post-translational modification of a ... -
Molecular motions at the 5 stem-loop of U4 snRNA: Implications for U4/U6 snRNP assembly
(2005-07-05)The human 15.5K protein binds to the 5' stem-loop of U4 snRNA (KtU4), promotes the assembly of the spliceosomal U4/U6 snRNP, and is required for the recruitment of the 61K protein and ... -
Post-translational generation of Cá-formylglycine in Prokaryotic Sulfatsases by Radical SAM-Proteins
(2004-02-16)Cá-formylglycine is the catalytic residue of sulfatases. FGly is generated by posttranslational modification of a cysteine (pro- and eukaryotes) or serine (prokaryotes) located in a conserved ... -
Protein dynamics in the nucleus: Implications for gene expression
(2005-11-08)Fluorescence recovery after photobleaching (FRAP) microscopy was used to determine the kinetic properties of Polycomb group proteins in whole living Drosophila organisms (embryos) and ... -
Resistenzentwicklung des Humanen Immundefizienzvirus Typ 1 gegen Azidothymidin in Zellkultur
(2004-07-19)AZT resistance is not restricted to the virus but may also develop on the cellular level. We have generated AZT-resistant HIV-1 variants through passages of HIV-1 in human T-cell lines ... -
Rezeptor-vermittelte Lieferung von Genen durch gezielte Liposomen und Quantum Dots
(2009-01-16)The design of liposomal carriers for gene or drug delivery is an active field in current biomedical research. An important issue is the targetin of the c ach i -
Röntgenstrahlen induzierte DNA- Doppelstrangbrüche in säugen Zellen in Abhängigkeit vom Zellzyklus.
(2002-11-25)The present study reports improvements in the neutral comet assay first introduced by (Singh and Stephans, 1997; Olive et al., 1998) to measure radiation induced DNA damage. Different ... -
Studies into the structural basis of the DNA uridine endonuclease activity of exonuclease III homolog Mth212
(2011-05-16)Mth212, an exonuclease III homolog from the archaeon Methanothermobacter thermoautotrophicus, compensates the lack of a DNA uracil glycosylase (UDG) in this organism by catalyzing direct ... -
The Regulatory Role of Syntaxin 1 N-terminal Conformation in Vesicle Priming and Exocytosis
(2004-12-16)During vesicle priming at the central synapse, Syntaxin 1, together with SNAP25 and Synaptobrevin, assemble into the synaptic SNARE complex. The formation of SNARE complex is thought to ... -
TIP47 is recruited to lipid droplets and important for the organelle biogenesis and function
(2004-09-27)The cytoplasmic protein TIP47 (tail interacting protein of 47kD) was characterized as a cargo selection device for MPRs (mannose 6-phosphate receptors) and supposed to determine MPR transport ... -
Use of peptide microarrays for mapping viral b cell epitopes
(2011-03-17)Mapping targets of antibodies - in particular neutralizing ones - is of great value for monitoring vaccination efficacy as well as for development of novel vaccines and reagents for ... -
Übertragung von BSE auf nicht humane Primaten als Modell für die variante Creutzfeldt-Jakob Erkrankung (vCJD) im Menschen
(2007-06-05)The EU-study QLK1-CT-2002-01096 was designed to assess the risk of vCJD (variant Creutzfeldt-Jakob disease) infection in humans via BSE-contaminated food in an animal model. Groups of six ... -
Wirkung schwerer Ionen auf strahlenresistente und strahlensensitive Tumorzellen
(2003-03-12)The reasons for the highly variable sensitivity of different cell types and tissues against ionising radiation are still unknown. The increased radiosensitivity was observed at the level ...