Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Braus, Gerhard Prof. Dr."
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DNA methylation as a potential epigenetic driver of morphological development in Candida albicans
(2022-01-04)Candida albicans is a commensal yeast in the mammalian gut, but also has retained its virulence potential while co-evolving in mammalian species. As a perfectly adapted opportunist colonizing mucosal surfaces, it is also ... -
The velvet protein Vel1 controls initial plant root colonization and conidia formation for xylem distribution in Verticillium wilt
(2021-08-24)The velvet family of regulatory proteins is well-conserved in fungi and links developmental processes and secondary metabolite production. These proteins comprise a velvet domain for DNA binding and dimerization with ... -
Developmental regulators and secreted effector molecules of the fungal pathogen Verticillium spp.
(2020-09-29)The haploid Verticillium dahliae and the allodiploid V. longisporum are two filamentous fungal pathogens, which colonize the plant vascular system of a broad host range including important crops. They survive outside of ... -
Interplay of Verticillium signaling genes favoring beneficial or detrimental outcomes in interactions with plant hosts
(2020-07-14)Verticillia and their plant hosts both contribute to pathogenesis as a consequence of their interaction. Evolution-driven genome extension includes hybridization, resulting in amphidiploid species as the rapeseed pathogen ... -
Translocator protein 18 ligand Emapunil protects against neurodegeneration in the MPTP mouse model of Parkinsonism
(2020-06-19)Parkinson’s disease (PD) is the second most common neurodegenerative disorder in old age. The presence of akinesia, rigidity and rest tremor caused by dopaminergic neuronal loss in the substantia nigra are the major clinical ... -
Towards the identification and functional characterization of Verticillium effectors involved in xylem hyperplasia formation in Arabidopsis
(2020-05-26)Isolates of the vascular plant pathogen Verticillium spp. can be categorized according to the disease phenotypes they induce on Arabidopsis thaliana Col-0 plants (Thole 2016). While Arabidopsis plants show no obvious disease ... -
Protein aggregation in the cytoplasm
(2020-05-20)The hypothesis motivating this thesis is that aggregation of proteins in the cytoplasm can have protective functions and can facilitate cell survival. Conversely, the disruption of functional aggregation can lead to cellular ... -
Variability of biofilm formation in Candida glabrata and Candida parapsilosis and its consequences on the infection process
(2019-08-30)The prevalence of Candida species has increased in the last two decades, becoming the third to fourth most common cause of infections in hospitals. In general, Candida spp. are opportunistic pathogens found as commensals ... -
Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes in late cortical development and beyond
(2019-08-29)The multi-subunit BAF (SWI/SNF) complex is capable of using energy generated from ATP hydrolysis to reorder chromatin structure. Such chromatin changes are known to affect cell biological processes through gene expression ... -
Characterization of a novel regulator of the unfolded protein response in Ustilago maydis and mammals
(2019-07-16)The endoplasmic reticulum (ER) is an eukaryotic organelle which is the entry point into the secretory pathway and responsible for protein synthesis and processing. The amount of proteins to be folded in the ER lumen is ... -
Analysis of Clp1-dependent UPR modulation in Ustilago maydis
(2019-06-13)The unfolded protein response (UPR) is a conserved signaling pathway, that is present in all eukaryotic cells and ensures endoplasmic reticulum (ER) homeostasis under stress conditions. In the phytopathogenic fungus U. ... -
Neurodegeneration induced by ß-synuclein in the context of the neurotransmitter dopamine
(2019-05-27)Objective: α-synuclein and degeneration of dopaminergic neurons have been closely associated to Parkinson´s disease. The interaction of α-synuclein with the neurotransmitter dopamine has been connected to neurodegeneration, ... -
Specific ubiquitin-dependent protein degradation requires a trimeric CandA complex in Aspergillus nidulans
(2019-05-20)E3 cullin-RING ubiquitin ligase complexes are activated by modification of their cullin scaffold protein with the ubiquitin-like modifier Nedd8. Deneddylases as the COP9 signalosome (CSN) or Den1/A interact and destabilize ... -
Taxonomic and Functional Characterization of Biopolymer-degrading Microbial Communities in the Intestinal Tract of Beavers
(2019-05-09)The mammalian gut harbors a complex and specialized microbiota, which includes all tree domains of life (Archaea, Bacteria, and Eukarya). Bacteria are the most abundant group within the gut system, and they take part in ... -
Cyclic monophosphate cyclase in Firmicutes: from basic to practical approach
(2019-01-30)Cyclic di-adenosine monophosphate (c-di-AMP) is a second messenger involved in diverse metabolic processes such as cell wall homeostasis, biofilm formation, antibiotic and heat resistance, among others. In Lactococcus ... -
Verticillium dahliae transcription factors Som1 and Vta3 control microsclerotia formation and sequential steps of plant root penetration and colonisation to induce disease
(2018-10-12)Verticillium dahliae belongs to the soil-borne ascomycete fungi. It causes wilt diseases and early senescence in more than 200 plant species including economically important crops. It can exist in the soil without a host ... -
Functional analysis of STRIPAK complex components in the filamentous ascomycete Sordaria macrospora
(2018-08-09)The striatin-interacting phosphatase and kinase (STRIPAK) complex is conserved in fungi and animals. The STRIPAK in the filamentous ascomycete Sordaria macrospora, was previously found to be essential for hyphal fusion and ... -
The interplay of SmNBR1 and SmATG8 in selective autophagy of the filamentous fungus Sordaria macrospora
(2018-03-19)Autophagy is a conserved ubiquitous degradation process in eukaryotic cells which is mainly investigated in the baker´s yeast Saccharomyces cerevisiae. It includes the random sequestration of defective and excessive proteins ... -
Regulation of Toxoplasma gondii bradyzoite differentiation in terminally differentiated skeletal muscle cells
(2017-11-28)Toxoplasma gondii is an intracellular protozoan parasite that infects warm-blooded animals including an estimated thirty percent of humans world-wide. In immunocompetent host, primary infection is usually asymptomatic but ... -
Etablierung eines Nachweisverfahrens zur Untersuchung der räumlichen und zeitlichen Verteilung mitochondrial translatierter Proteine mit hochauflösender STED-Mikroskopie durch metabolische Markierung mit nicht-kanonischen Aminosäuren
(2017-09-14)Metabolic labeling of nascent polypeptides using non-canonical amino acids is a valuable tool enabling researchers to introduce bioorthogonal functional groups into proteins. These can subsequentially be used for identifying ...