Dokumente GZMB - Göttinger Zentrum für molekulare Biowissenschaften nach Titel
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Filtered spaced-word matches: a novel approach to fast and accurate sequence comparison
(2019-01-22)Standard methods for biological sequence comparison and phylogeny reconstruction are traditionally based on sequence alignments. These methods are very accurate but also computationally expensive. Because of the exponentially ... -
Functional Characterisation of Syndecan, a heparan sulpahte proteoglycan, in Slit/Robo signalling
(2008-04-25)Syndecan (Sdc) is a type I transmembrane protein characterized by the presence of linear sugar chains called heparan sulphate glycosaminoglycans (HSGAGs) linked to its extracellular domain. Sdc was shown to be critical for ... -
Functional Characterization of Hereditary Spastic Paraplegia Proteins Spastin and ZFYVE27
(2010-04-20)Hereditary spastic paraplegias (HSP) are a heterogeneous group of genetic disorders characterized by progressive spasticity in the lower limbs caused primarily due to dysfunction of ... -
Functional conservation of germ plasm organizers Bucky ball in zebrafish and Drosophila Oskar
(2018-12-12)The reproductive cells of many animals are specified by a maternal determinant termed germ plasm. Cells inheriting germ plasm during embryogenesis will develop into primordial germ cells (PGCs), the precursors to eggs and ... -
Functions of Vti1a and Vti1b in the Development of the Mouse Nervous System: Evidence from Double Knockout Mice
(2009-02-12)In eukaryotic cells molecules need to be transported to their correct intracellular destination without compromising the structural integrity of cellular compartments in order to maintain homoeostasis and to allow appropriate ... -
Fundamental Efforts to Develop Novel Biotechnological Approaches in Pest Management Applications against Coleoptera: Transcriptomic Exploration of the Chemical Defense Mechanism in the Red Flour Beetle, Tribolium castaneum
(2013-04-24)Chemical defense is one of the most important traits, which endow insects with the ability to conquer diverse ecological environments. Chemical secretions are used for defense against anything from vertebrate or invertebrate ... -
Die Funktion der inflammatorischen CCR2+ Monozyten bei der postnatalen Mikrogliaentwicklung und bakteriellen Meningitis
(2008-02-12)The central nervous system (CNS) differs from other organs in its privileged status in relation to the immune system. To ensure a specific and stable neuronal environment, the blood-brain barrier separates it from the ... -
Gene prediction in metagenomic sequencing reads
(2009-11-13)Gene prediction is an essential step in the annotation of metagenomic sequencing reads. Since most metagenomic reads cannot be assembled into long contigs, specialized gene prediction tools are required for the analysis ... -
Genomics and Phylogeny of Motor Proteins: Tools and Analyses
(2008-02-19)This work is a collection of several projects that are mainly concerned with the genomics and the phylogeny of Myosins. Two database driven web applications are described. The first, CyMoBase (www.cymobase.org) ... -
Growth, fruiting body development and laccase production of selected coprini
(2008-11-26)The coprini are a form group of mushrooms that grow mainly on compost and horse dung and that for over 100 years were thought to present one genus. Only in 2001 it was discovered by Redhead and coworkers by molecular ... -
Identifizierung und Charakterisierung extrazellulärer Proteine unter dem Einfluss von Verticillium longisporum in Arabidopsis thaliana und Raps (<i>Brassica napus</i>)
(2008-03-04)Verticillium species are soil-borne, xylem-colonizing fungi with worldwide distribution in temperate and subtropical regions. They cause vascular disease in many agriculturally important crops. Verticillium longisporum ... -
Inducing neuroplasticity in the human motor system by transcranial magnetic stimulation: from pathophysiology to a therapeutic option in movement disorders
(2010-05-17)Transcranial magnetic stimulation (TMS) has become a well established method to non-invasively assess corticospinal excitability in human subjects. In addition repetitive transcranial magnetic stimulation (rTMS) is capable ... -
Investigation of cpeb1 transcript regulation and potential functions of CPEB1 in germline development in X. laevis
(2017-11-17)Germline specification represents the first functional segregation between two cell populations in the embryo. The germ cell lineage is the source of genetic variation and is essential for the continuity of the species. ... -
Investigation of Protein Structure and Dynamics
(2009-07-22)This thesis addresses three aspects of protein function:Part I describes the structural investigation of a calmodulin-peptide complex by NMR spectroscopy. The intracellular calcium sensor ... -
Metabolic and developmental functions of the transcription factor Gcn4p of Saccharomyces cerevisiae
(2011-10-17)The bakers’ yeast Saccharomyces cerevisiae executes two well established pathways, the ‘General Amino Acid Control’ (GAAC) and the ‘Unfolded Protein Response’ (UPR), which are in contrast to mammals not essential but ... -
Metabolism of NHP and SA
(2023-01-02)When mobile organisms face a threat, they have the options of a fight or flight as reaction. The sessile nature of plants narrows their response option down to defend themselves against the threat. Therefore, plants developed ... -
Mikroautophagischer Abbau von Teilen der Kernhülle und Untersuchungen zum Transport und der Aktivität von Atg15p in der Hefe Saccharomyces <i>cerevisiae</i>
(2008-08-12)Autophagy is a ubiquitous process, occurring in all eukaryotic cells. Microautophagy sequesters cytoplasm or organelles by invagination or septation of the vacuolar membrane. In Saccharomyces ... -
Molecular architecture of SF3B and the structural basis of splicing modulation
(2019-06-20)During splicing non-coding introns are excised from the transcribed pre-messenger RNA (pre-mRNA), and the protein-coding exons are ligated to generate the mature mRNA. In cells, the pre-mRNA splicing reaction is catalyzed ... -
Ein neu entdeckter Weg der Reparatur hydrolytisch geschädigter DNA-Cytosinreste, etabliert im thermophilen Archaeon Methanothermobacter thermautotrophicus ΔH
(2007-11-21)The DNA bases cytosine, adenine and guanine can be deaminated at the exocyclic aminogroups by spontaneous hydrolysis. Cytosine deamination leads to the RNA base uracil and is of particular mutagenic relevance, because ... -
Participation of Eag1 in tumor relevant pathways
(2010-01-12)Ether--go-go-1 (Eag1) is a CNS-localized voltage-gated potassium channel that is found ectopically expressed in a majority of extra-cranial solid tu- mors. While evidence linking Eag1 to tumor biology has been well ...