Dokumente GZMB - Göttinger Zentrum für molekulare Biowissenschaften nach Titel
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Gene prediction in metagenomic sequencing reads
(2009-11-13)Gene prediction is an essential step in the annotation of metagenomic sequencing reads. Since most metagenomic reads cannot be assembled into long contigs, specialized gene prediction tools are required for the analysis ... -
Genomics and Phylogeny of Motor Proteins: Tools and Analyses
(2008-02-19)This work is a collection of several projects that are mainly concerned with the genomics and the phylogeny of Myosins. Two database driven web applications are described. The first, CyMoBase (www.cymobase.org) ... -
Growth, fruiting body development and laccase production of selected coprini
(2008-11-26)The coprini are a form group of mushrooms that grow mainly on compost and horse dung and that for over 100 years were thought to present one genus. Only in 2001 it was discovered by Redhead and coworkers by molecular ... -
Identifizierung und Charakterisierung extrazellulärer Proteine unter dem Einfluss von Verticillium longisporum in Arabidopsis thaliana und Raps (<i>Brassica napus</i>)
(2008-03-04)Verticillium species are soil-borne, xylem-colonizing fungi with worldwide distribution in temperate and subtropical regions. They cause vascular disease in many agriculturally important crops. Verticillium longisporum ... -
Inducing neuroplasticity in the human motor system by transcranial magnetic stimulation: from pathophysiology to a therapeutic option in movement disorders
(2010-05-17)Transcranial magnetic stimulation (TMS) has become a well established method to non-invasively assess corticospinal excitability in human subjects. In addition repetitive transcranial magnetic stimulation (rTMS) is capable ... -
Investigation of cpeb1 transcript regulation and potential functions of CPEB1 in germline development in X. laevis
(2017-11-17)Germline specification represents the first functional segregation between two cell populations in the embryo. The germ cell lineage is the source of genetic variation and is essential for the continuity of the species. ... -
Investigation of Protein Structure and Dynamics
(2009-07-22)This thesis addresses three aspects of protein function:Part I describes the structural investigation of a calmodulin-peptide complex by NMR spectroscopy. The intracellular calcium sensor ... -
Metabolic and developmental functions of the transcription factor Gcn4p of Saccharomyces cerevisiae
(2011-10-17)The bakers’ yeast Saccharomyces cerevisiae executes two well established pathways, the ‘General Amino Acid Control’ (GAAC) and the ‘Unfolded Protein Response’ (UPR), which are in contrast to mammals not essential but ... -
Metabolism of NHP and SA
(2023-01-02)When mobile organisms face a threat, they have the options of a fight or flight as reaction. The sessile nature of plants narrows their response option down to defend themselves against the threat. Therefore, plants developed ... -
Mikroautophagischer Abbau von Teilen der Kernhülle und Untersuchungen zum Transport und der Aktivität von Atg15p in der Hefe Saccharomyces <i>cerevisiae</i>
(2008-08-12)Autophagy is a ubiquitous process, occurring in all eukaryotic cells. Microautophagy sequesters cytoplasm or organelles by invagination or septation of the vacuolar membrane. In Saccharomyces ... -
Molecular architecture of SF3B and the structural basis of splicing modulation
(2019-06-20)During splicing non-coding introns are excised from the transcribed pre-messenger RNA (pre-mRNA), and the protein-coding exons are ligated to generate the mature mRNA. In cells, the pre-mRNA splicing reaction is catalyzed ... -
Ein neu entdeckter Weg der Reparatur hydrolytisch geschädigter DNA-Cytosinreste, etabliert im thermophilen Archaeon Methanothermobacter thermautotrophicus ΔH
(2007-11-21)The DNA bases cytosine, adenine and guanine can be deaminated at the exocyclic aminogroups by spontaneous hydrolysis. Cytosine deamination leads to the RNA base uracil and is of particular mutagenic relevance, because ... -
Participation of Eag1 in tumor relevant pathways
(2010-01-12)Ether--go-go-1 (Eag1) is a CNS-localized voltage-gated potassium channel that is found ectopically expressed in a majority of extra-cranial solid tu- mors. While evidence linking Eag1 to tumor biology has been well ... -
Patched-assoziierte Tumoren: Modifikatorgene und Pathogenese
(2008-06-05)Patched (Ptch), a component of the Hedgehog (Hh)/Ptch signalling cascade, is frequently mutated in basal cell carcinoma (BCC), medulloblastoma (MB) and rhabdomyosarcoma (RMS). Ptchneo67/+ mice, in which exons 6 and 7 are ... -
Prevention and treatment: Effects on pathological alterations in transgenic Alzheimer’s disease mouse models
(2021-06-21)Alzheimer’s disease (AD) is a neurodegenerative disorder representing the most common form of dementia worldwide. To date, no successful therapeutic approach to treat AD has been developed, hence preventive strategies ... -
Proteome-wide Identification of New Molecular Targets Affected by Methotrexate in Acute Promyelocytic Leukaemia Cell Line
(2007-06-11)Methotrexate (MTX) was first introduced as a cytotoxic agent that inhibits nucleotide biosynthesis in various cancer disorders. Accumulating evidences suggest that MTX inhibits the proliferation of malignant cells by ... -
The rhizosphere effects of <i>Fagus sylvatica</i> L. and <i>Fraxinus excelsior</i> L. saplings on greenhouse gas fluxes between soil and atmosphere
(2012-12-07)Tree species influence the soil through stemflow and throughfall water, leaf litter and the root system. Little is known about the effects of tree roots on the C and N dynamics of the soil and the gas exchange with ...
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The role of Lissencephaly-1 protein in male germ cell differentiation
(2009-07-24)In the present study the function of Lissencephaly-1 protein in male germ cell differentiation was analysed. A gene trap mouse model (L39) in which a gene trap vector had integrated in intron 2 of Lis1 gene resulted in ... -
The Role of the HECT-Type Ubiquitin Ligases WWP1 and WWP2 in Nerve Cell Development and Function
(2012-03-15)Posttranscriptional modification of proteins through the ubiquitin pathway has recently emerged as an essential regulatory mechanism controlling neuronal development and function. WW domain-containing protein-1 and -2 ... -
The signal transduction of synapse formation and it's failure in Rett syndrome
(2017-04-26)The mechanistic target of rapamycin (mTOR) perceives and integrates various extracellular and intracellular signals and regulates cellular growth and homeostasis. The evolutionary conserved serine/threonine kinase can form ...