Browse by type "doctoralThesis"
Now showing items 1-20 of 37
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Assembly pathway of the fungal COP9 signalosome
(2022-12-20)The conserved eight-subunit COP9 signalosome (CSN complex) controls the exchange of E3 ubiquitin cullin RING ligase receptors, and therefore the specificity of protein degradation in eukaryotic cells and it is required ... -
Prevention and treatment: Effects on pathological alterations in transgenic Alzheimer’s disease mouse models
(2021-06-21)Alzheimer’s disease (AD) is a neurodegenerative disorder representing the most common form of dementia worldwide. To date, no successful therapeutic approach to treat AD has been developed, hence preventive strategies ... -
Characterization of Mitochondrial Calcium Uniporter in Barth Syndrome Models
(2020-07-15)The Barth Syndrome (BTHS) is caused by the loss of the mitochondrial acyltransferase tafazzin, which is involved in the remodeling process of the hallmark mitochondrial glycerophospholipid cardiolipin. Cardiolipin maintains ... -
Molecular architecture of SF3B and the structural basis of splicing modulation
(2019-06-20)During splicing non-coding introns are excised from the transcribed pre-messenger RNA (pre-mRNA), and the protein-coding exons are ligated to generate the mature mRNA. In cells, the pre-mRNA splicing reaction is catalyzed ... -
Charakterisierung klinisch-relevanter Bakterien mittels Proteotypisierung
(2019-05-03)In case of a disease outbreak fast and reliable detection of the source of infection is crucial. For this reason, typing of microbial species, also at the below-species level is an important task of clinical microbiological ... -
Filtered spaced-word matches: a novel approach to fast and accurate sequence comparison
(2019-01-22)Standard methods for biological sequence comparison and phylogeny reconstruction are traditionally based on sequence alignments. These methods are very accurate but also computationally expensive. Because of the exponentially ... -
Functional conservation of germ plasm organizers Bucky ball in zebrafish and Drosophila Oskar
(2018-12-12)The reproductive cells of many animals are specified by a maternal determinant termed germ plasm. Cells inheriting germ plasm during embryogenesis will develop into primordial germ cells (PGCs), the precursors to eggs and ... -
Chromatin affinity purification coupled with mass spectrometry indetifies novel histone ubiquitylation interactors
(2018-07-12)Histone ubiquitylation is the post-translational covalent attachment of ubiquitin to histones. Ubiquitylation of histones regulates chromatin-templated processes through a combination of structural and functional effects. ... -
Investigation of cpeb1 transcript regulation and potential functions of CPEB1 in germline development in X. laevis
(2017-11-17)Germline specification represents the first functional segregation between two cell populations in the embryo. The germ cell lineage is the source of genetic variation and is essential for the continuity of the species. ... -
The signal transduction of synapse formation and it's failure in Rett syndrome
(2017-04-26)The mechanistic target of rapamycin (mTOR) perceives and integrates various extracellular and intracellular signals and regulates cellular growth and homeostasis. The evolutionary conserved serine/threonine kinase can form ... -
Characterization of Lipoxygenases from Cyanothece sp.
(2016-12-12)Lipoxygenases (LOXs) are non-heme iron- or manganese-containing dioxygenases that catalyze the regio- and stereospecific peroxidation of polyunsaturated fatty acids containing at least one cis,cis-1,4-pentadiene system. ... -
A functional analysis of a signaling center of the insect head
(2014-08-06)Most of our knowledge on embryonic development comes from the fruit y Drosophila melanogaster. An elaborate genetic model explains the segmentation process in the trunk. However, the anterior head region is patterned ... -
Fundamental Efforts to Develop Novel Biotechnological Approaches in Pest Management Applications against Coleoptera: Transcriptomic Exploration of the Chemical Defense Mechanism in the Red Flour Beetle, Tribolium castaneum
(2013-04-24)Chemical defense is one of the most important traits, which endow insects with the ability to conquer diverse ecological environments. Chemical secretions are used for defense against anything from vertebrate or invertebrate ... -
The rhizosphere effects of <i>Fagus sylvatica</i> L. and <i>Fraxinus excelsior</i> L. saplings on greenhouse gas fluxes between soil and atmosphere
(2012-12-07)Tree species influence the soil through stemflow and throughfall water, leaf litter and the root system. Little is known about the effects of tree roots on the C and N dynamics of the soil and the gas exchange with ...
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Analyse der Funktion des Miz1 Gens bei Kardiomyopathie
(2012-03-27)The sarcomeric Z-disc is the main structure of the decentralized model of the muscle mechanotransduction. Proteins, which are anchored to the Z-disc are associated with cardiomyopathy. An example is the muscle LIM protein, ... -
The Role of the HECT-Type Ubiquitin Ligases WWP1 and WWP2 in Nerve Cell Development and Function
(2012-03-15)Posttranscriptional modification of proteins through the ubiquitin pathway has recently emerged as an essential regulatory mechanism controlling neuronal development and function. WW domain-containing protein-1 and -2 ... -
Metabolic and developmental functions of the transcription factor Gcn4p of Saccharomyces cerevisiae
(2011-10-17)The bakers’ yeast Saccharomyces cerevisiae executes two well established pathways, the ‘General Amino Acid Control’ (GAAC) and the ‘Unfolded Protein Response’ (UPR), which are in contrast to mammals not essential but ... -
Inducing neuroplasticity in the human motor system by transcranial magnetic stimulation: from pathophysiology to a therapeutic option in movement disorders
(2010-05-17)Transcranial magnetic stimulation (TMS) has become a well established method to non-invasively assess corticospinal excitability in human subjects. In addition repetitive transcranial magnetic stimulation (rTMS) is capable ... -
Functional Characterization of Hereditary Spastic Paraplegia Proteins Spastin and ZFYVE27
(2010-04-20)Hereditary spastic paraplegias (HSP) are a heterogeneous group of genetic disorders characterized by progressive spasticity in the lower limbs caused primarily due to dysfunction of ... -
Untersuchungen zur Funktion der Gene MPH1 und MMS2 aus Saccharomyces cerevisiae bei der fehlerfreien Umgehung von replikationsarretierenden DNA-Schäden
(2010-02-25)in vivo error free bypass of replication blocking lesions is done by at least two distinct processes: homologous recombination via sister chromatid interaction (SCI) and post replicative repair (PRR). Additionally PRR is ...