Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Irniger, Stefan PD Dr."
Now showing items 1-15 of 15
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Zelltyp-spezifische Interaktionen von Toxoplasma gondii und murinen Skelettmuskelzellen in vitro
(2014-06-26)Toxoplasma gondii is one of the most common intracellular protozoan parasites worldwide and an important human pathogen. Its life cycle includes three stages: sporozoites, tachyzoites and bradyzoites. While sporozoites are ... -
Impact of plant species, N fertilization and ecosystem engineers on the structure and function of soil microbial communities
(2014-02-26)Soil microbial communities are directly and indirectly influenced by a complex system of cross-interactions between different biotic and abiotic factors influencing each other, such as plant species and their respective ... -
The role of Pcl5p and Pcl7p in the Gcn4p stability regulation of Saccharomyces cerevisiae
(2011-05-09)In the baker s yeast Saccharomyces cerevisiae, the transcriptional activator Gcn4p is the central element of the general amino acid control network that induces more than 500 genes in ... -
Adhesion of the rapeseed pathogen Verticillium longisporum to its host Brassica napus: Uncovering adhesion genes and the evolutionary origin of the fungus
(2011-05-06)Verticillium longisporum, a soil-borne plant pathogen, is an emerging problem for oilseed rape and other crucifers. The mechanism of infection through plant roots and the evolutionary origin of this fungus are still not ... -
Investigations into the mode of action of the DNA uridine endonuclease Mth212 of Methanothermobacter thermautotrophicus ΔH
(2010-03-05)Spontaneous hydrolytic deamination of cytosine to uracil is one of the most frequent DNA modifications during cellular everyday metabolism. To counteract this mutagenic effect, most organisms ... -
The tyrosine regulated DAHP synthase and the biosynthetic pathway of aromatic amino acids in Saccharomyces cerevisiae
(2006-10-30)3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthases (EC 2.5.1.54) catalyze the initial reaction of the aromatic amino acid biosynthetic pathway. Phosphoenolpyruvate (PEP) and ... -
Stability regulation of Gcn4p in Saccharomyces cerevisiae
(2006-05-16)Selective rapid protein degradation is an important mechanism for distinct biological events, including cell cycle progression, signal-transduction, and differentiation. Thus, the stability ... -
CsnA Dependent Development and Regulation of Amino Acid Biosynthesis of the Filamentous Ascomycete <i>Aspergillus nidulans</i>
(2006-02-24)Aspergilli comprise a heterogenous group of filamentous fungi. The ascomycete Aspergillus nidulans represents a well studied eukaryotic model system for metabolism and development. Aspergillus ... -
Funktionelle Charakterisierung bakterieller Histondeacetylase-ähnlicher Amidohydrolasen (HDAH)
(2005-12-05)Until today, there is only little information about posttranslational modifications, especially acetylation of polypeptides in procaryotes to find in the literature. This thesis tries to ... -
Neue Enzyminhibitoren und Rezeptoragonisten durch Variation funktionaler Schleifen von Mikroproteinen
(2005-10-25)Cystine knot microproteins are peptidic biomolecules with approximately 28-40 amino acids in length. They are able to fold into extremely stable threedimensional structures characterized ... -
Proteindesign zur Verbesserung des Nucleosidanaloga-Umsatzes in menschlichen Zellen: Desoxycytidin-Kinase und UMP/CMP-Kinase
(2005-08-26)The human nucleoside and nucleoside monophosphate kinases play an important role in the activation of many nucleoside analogs which are used in the treatment of viral and cancer therapies. ... -
Recognition of basic sorting motifs within synaptic membrane cargo proteins by the clathrin-adaptor complex AP-2
(2005-08-24)Communication in the central nervous system (CNS) occurs via chemical synapses, intercellular asymmetric junctions between an axon and the dendrite of a neighbouring neuron. Synapses comprised ... -
Crystallographic studies on a cold adapted subtilase and proteins involved in mRNA processing
(2005-06-03)The crystal structure of a subtilisin-like serine proteinase from the psychrotrophic marine bacterium, Vibrio sp. PA-44, was solved by means of molecular replacement and refined at 1.84 Å ... -
Strukturelle und funktionelle Untersuchungen zum m3G-Cap-vermittelten Kernimport spleißosomaler U snRNPs durch Snurportin1
(2005-02-01)During snRNP biogenesis the snRNAs are exported into the cytoplasm, where the assembly with the common Sm proteins occurs and the 5´cap nucleotide is modified from an 7-methyl-guanosine ... -
Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
(2004-11-18)Hepatic stellate cells (HSCs) and liver myofibroblasts (LMFs) represent major cell populations involved in liver fibrogenesis. Several lines of evidence demonstrate that in contrast to LMFs, ...