Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Jäckle, Herbert Prof. Dr."
Now showing items 1-11 of 11
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An in vivo RNAi screen identifies evolutionary conserved Drosophila fat storage regulators
(2014-05-12)One main goal for all organisms, in order to survive under environmental changes, is to maintain energy homeostasis. Energy homeostasis depends mainly on three processes, the energy uptake, energy storage and energy ... -
Genome-wide RNAi screening reveals glial phosphoethanolamine ceramide is critical for axonal ensheathment
(2012-11-07)Glia play a major role in many processes during the development of the nervous system both in vertebrates and in invertebrates. One of the crucial functions of glia is the insulation of axons to provide them with trophic ... -
Charakterisierung von lipid droplet-Regulatoren der Fruchtfliege <i>Drosophila melanogaster</i>
(2012-09-28)The storage of lipids as a reservoir for energy and biosynthetic building blocks is a central feature of life. At the same time, storage amounts need to be tightly controlled since a failed regulation severely impacts the ... -
Functional characterization of CDY family proteins and their role in recognition of the heterochromatic histone H3K9me3 modification
(2010-01-14)In the nucleus of eukaryotic cells the DNA is wrapped around octamers of histone proteins containing two H2A-H2B dimers and one (H3-H4)2 tetramer. This entity represents the basic repeating ... -
Evolution of Bicoid-dependent hunchback Regulation in Diptera
(2006-12-20)An early segmentation gene of Drosophila melanogaster, hunchback, with an evolutionarily conserved function but diverging regulation was used as an entry point to explore the evolution of early ... -
Characterization of synaptic protein complexes in Drosophila melanogaster
(2006-08-25)Synaptic transmission at chemical synapses is directional: the presynapse is defined as the compartment from which neurotransmitter is released. The postsynaptic site harbors the machinery for neurotransmitter reception ... -
Role of Smad-interacting Protein 1 (Sip1/Zfhx1b) in the development of the cerebral cortex
(2006-05-19)Smad-interacting protein 1 (Sip1/Zfhx1b) is a transcription factor that has been previously implicated in TGF-β/BMP signaling and in the etiology of the Mowat-Wilson syndrome. The expression ... -
Mechanistic Plasticity and Molecular Recognition: The Structural Biology of the MAP Kinase Interacting Kinases 1 and 2, the NAD Synthetase and the Zinc Finger Associated Domain
(2005-11-08)In this study a set of four different proteins has been examined structurally and functionally. The core results embody the structural analysis of the catalytic domains of the mitogen ... -
Protein dynamics in the nucleus: Implications for gene expression
(2005-11-08)Fluorescence recovery after photobleaching (FRAP) microscopy was used to determine the kinetic properties of Polycomb group proteins in whole living Drosophila organisms (embryos) and ... -
In vivo imaging of long-term changes in the Drosophila neuromuscular junction
(2005-02-11)So far synaptogenesis could hardly be studied in its native settings. In this thesis, an assay which allows the study of synapse formation and maturation in vivo was established in a ... -
Inhibition of Hox function by the cell cycle regulator geminin
(2004-11-16)In the work, I have shown that murine Geminin associates transiently with members of the Hox-repressing Polycomb complex dependent on the cell cycle, with the chromatin of Hox regulatory ...