Browsing Human- und Zahnmedizin by Referee "Wienands, Jürgen Prof. Dr."
Now showing items 1-20 of 20
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Direct, indirect and longitudinal immunological effects of anti-CD20 mediated B cell depletion in Multiple Sclerosis
(2021-08-10)B cell depletion via anti-CD20 antibodies is a highly effective treatment for multiple sclerosis (MS). However, little is known about the maturation/activation stage of the returning B cell population after treatment ... -
Vascular Cell Adhesion Molecule-1 (VCAM-1) modulates plasticity of human melanoma cells
(2021-04-09)Malignant melanoma is by far the type of skin cancer with the highest mortality. As is the case for most cancers, metastasis is the major limiting factor determining therapeutic options and survival of the patients. Despite ... -
The αE(CD103)β7 integrin and its role on regulatory T-cells in allergic contact dermatitis
(2020-10-26)The aim of this study was to determine whether CD103 deficiency causes an impairment in the regulatory function of Tregs in allergic contact dermatitis and to investigate possible mechanisms. This study found that Tregs ... -
IL10 und CpG induzieren über STAT3 und NF-κB die Zellproliferation und die Genexpression des Glutaminolyseenzyms GOT2 in der Modellzelllinie P493-6
(2019-05-03)The diffuse large B-cell lymphoma (DLBCL) is an aggressive Non-Hodgkin's lymphoma. A better understanding of oncogenic signaling pathways and tumor induced reprogrammed cell metabolism of these lymphomas is essential for ... -
Konstitutive Protein-Protein-Interaktionen regulieren die Aktivität der Bruton-Tyrosin-Kinase in B-Zellen
(2017-05-17)Protein tyrosine kinase Btk is a crucial effector for the ITAM dependent B-cell antigen receptor (BCR) signaling pathway. Its absence or dysfunction leeds to X-linked agammaglobulinaemia (XLA) in humans. Phosphorylation-dependent ... -
Dynamische Interaktion zwischen Leukozyten und Endothelzellen unter dem Einfluss von TNFα und Adalimumab
(2015-03-03)Several biologics were approved during the past decades for the therapy of psoriasis. One of these compounds is adalimumab, a fully human antibody directed against TNFα, a central cytokine that plays a pivotal role in the ... -
Regulation der „spleen tyrosine kinase“ Syk im B-Zell-Antigen-Rezeptor-Signalweg
(2013-11-25)The “spleen tyrosine kinase” Syk offers transducer functions for a number of ITAM-based immune cell receptors and is critical for the development and activation of B lymphocytes. Furthermore Syk has been implicated in the ... -
Posttranskriptionale Veränderungen der E3-Ubiquitin-Ligase IMP (impedes mitogenic signal propagation)
(2013-10-08)The ERK1/2 cascade is associated with determining cellular processes like cell growth, differentiation, cell division and apoptosis. Furthermore it is awarded with an essential role in cardiac hypertrophy. It was shown ... -
Inhibition des Interferon-Beta-Systems durch Tribec-Virus
(2013-01-03)The Tribec virus (TRBV) is a tick-transmitted Orbivirus (family Reoviridae) which is suspected to cause neurologic aseptic encephalitis in humans. The activation of the interferon system is the first immune response in ... -
Die Organisation von Signalnetzwerken in B-Lymphozyten
(2012-07-17)B cell antigen receptors (BCR) transduce signals that regulate not only proliferation and differentiation processes but also apoptosis. To regulate such a variety of biological responses BCR employ complex and tightly ... -
CIN85/CD2AP-based protein complexes in B cell antigen receptor signalling
(2012-07-12)Early B cell antigen receptor (BCR) signal transduction involves formation of multimeric protein complexes and their recruitment to BCR-containing areas in the plasma membrane. One such membrane-targeted signalosome is the ... -
Zum Einfluss von DYRK1A auf den aktivierten Calcineurin/NFAT-Signalweg und die Hypertrophie in Kardiomyozyten
(2012-05-24)Aims: The calcineurin and nuclear factor of activated T cells (NFAT) pathway can mediate cardiac pro-hypertrophic signalling. Recently, it has been shown that dual-specificity tyrosine-phosphorylation regulated kinase 1A ... -
Zum Einfluss des Calcineurin and Ras binding protein (Carabin) auf die Wachstumsregulation von Kardiomyozyten
(2012-03-26)In cardiomyocytes Calcineurin-NFAT signaling and ERK/MAPK signaling play essential roles in the pathogenesis of cardiac hypertrophy and heart failure. The Calcineurin and Ras binding protein ... -
Studies on adaptor proteins that shape antigen receptor-proximal signal transduction in B lymphocytes
(2011-08-15)Signals that are transduced by the B cell antigen receptor (BCR) control B cell development and activation. Engagement of the BCR initiates the assembly and activation of the antigen ... -
Analyse prognostischer Faktoren für die TNFα Antagonisten-Therapie bei Rheumatoider Arthritis
(2011-06-08)The pivotal cytokine in rheumatoid arthritis (RA) is the inflammatory tumor necrosis factor-alpha (TNFα). It mediates and triggers pain, inflammation and bone destruction. Since now there ... -
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
(2011-01-27)Oligodendrocytes are the myelin forming cells of the central nervous system. These cells synthesize vast amounts of membrane during the active phase of myelination. In addition, membrane ... -
Tyrosinkinaseinhibition bei humanen Non-Hodgkin-Lymphomen: Präklinische Evaluation von Sorafenib
(2010-11-17)A significant part of patients with aggressive lymphoma can be cured by current chemotherapy regimens. However, for patients with peripheral T-cell lymphoma or patients with relapsed ... -
Untersuchung einer Calcineurin-bindungsdefizienten FKBP12.6-Mutante in Kardiomyozyten
(2010-07-26)The ryanodin receptor, the largest known ion channel of the heart muscle cell is known as a multi protein complex. It´s activity is regulated by proteins like kinases and phosphateses. ... -
Etablierung und Charakterisierung einer Tetracyclin-induzierbaren PHD2-Knockdown-HeLa-Zelllinie
(2010-07-15)Prolyl-4-Hydroxylase Domain (PHD) enzymes 1-3 are oxygen-dependent enzymes, which hydroxylate the hypoxia-inducible factor (HIF) and target it for proteasomal degradation. HIF-1 is the ... -
Pioneering studies on the gene order, DNA sequence and evolution of the MHC class I region in the new world primate Callthrix jacchus
(2007-08-02)Analysis of MHC class I region in common marmoset (Callithrix jacchus) was made with 42 BAC clones. These clones containing class I region genes were identified for the purpose of ...