Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Hardeland, Rüdiger Prof. Dr."
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Molecular mechanisms of the cytokine-dependent induction of the heme oxygenase-1 gene: in vivo and in vitro studies
(2004-09-27)Heme oxygenase 1 (HO-1) is the inducible enzyme which catalyzes the rate-limiting reaction of heme degradation yielding carbon monoxide (CO), divalent iron (Fe2+), and biliverdin. Due to a ... -
Molekulare Mechanismen der Regulation der Glukagon-Gentranskription durch die Pax6-Homöodomäne
(2007-06-05)The peptide hormone glucagon increases glucose output from the liver and thus maintains sufficient blood glucose levels during the fasting state. Malfunctions in biosynthesis and secretion ... -
Neuroautonome Regulation und deren emotionale Modulation bei Mäusen
(2005-05-20)In this dissertation, characteristic somatomotor-, neuroautonomic- and endocrine responses of mice to external stimuli with innate or learned aversive attributes were investigated. Unconditioned ... -
Nuclear transport of the DNA fragmentation factor via the classical importin α/β-pathway
(2007-11-02)One of the biochemical hallmarks of apoptosis is internucleosomal DNA fragmentation mediated by the endonuclease DNA fragmentation factor (DFF) 40. In proliferating cells DFF40 is expressed ... -
On the pathophysiological significance of CD154/CD40-mediated leukocyte-endothelial cell interaction
(2003-05-22)CD154/CD40 interactions play a pivotal role in both humoral and cellular immune responses. Their involvement in the pathogenesis of chronic inflammatory bowel disease (IBD) has been revealed by increased expression of ... -
Patterns of post-translational histone modifications, chromatin condensation and DNA fragmentation during apoptosis
(2006-04-11)Cell shrinkage, formation of apoptotic bodies and chromatin fragmentation through cleavage of nucleosomal DNA into different fragment sizes catalysed by the DNase CAD (DFF40) are hallmarks ... -
Possible Influences of Circadian Melatonin on the Function of Neurosecretory Neurons and Serotonin-Modulated Behavior on Crayfish.
(2009-01-15)Crustaceans have frequently been used to study the neuroethology of diverse function as agonistic behavior and circadian rhythms. Whether the highly stereotyped and quantifiable agonistic ... -
Promotoranalyse und Expressionsstudien der murinen und humanen fork head homologen Gene Foxq1 und FOXQ1
(2002-02-18)Transcription factors of the fork head gene family play an important role during embryogenesis. The importance of this gene family shows up also in the fact that mutations in different human fork head genes lead to ... -
Proteomanalyse lysosomaler Membranen: Identifizierung und Charakterisierung neuer lysosomaler Membranproteine
(2009-06-18)Lysosomes are intracellullar acidic vesicles, which contain a variety of soluble and membrane-bound proteins like hydrolases and transport-systems. They are found in all nucleated ... -
Redoxmodulation Hippokampaler Neurone
(2007-11-19)Mitochondria constantly release various amounts of superoxide anions which are usually rapidly converted to H2O2. Especially disturbance of mitochondrial function can lead to an increased ... -
Regulation of rat Liver Glucokinase Gene Expression by Sterol Regulatory Element Binding Protein-1a and Forkhead box classO1 Transcription factors
(2008-10-13)Glucokinase (GK) also known as hexokinase IV catalyzes phosphorylation of glucose to glucose-6-phosphate. In contrast to other hexokinases, GK has a low affinity for glucose, is not ... -
Rezeptor-vermittelte Lieferung von Genen durch gezielte Liposomen und Quantum Dots
(2009-01-16)The design of liposomal carriers for gene or drug delivery is an active field in current biomedical research. An important issue is the targetin of the c ach i -
Role of intestinal epithelium in inflammatory bowel disease: effect of cytokines and glucocorticoids on CXCL8 and CXCL10 gene expression and NF-kB signalling in intestinal epithelial cell lines
(2008-04-24)Activation of intestinal epithelial cells (IEC) may occur either by luminal antigens stimulation or by inflammatory signals deriving from immune cells in the close vicinity. Production of chemokines by the intestinal ... -
Role of the CD40 receptor/CD154 ligand dyad in the control of smooth muscle cells phenotype
(2003-12-18)In the pathogenesis of atherosclerosis, circulating leukocytes adhere to endothelial cells, migrate through them and enter the vessel wall. CD40, a member of the tumor necrosis factor ... -
Role of transport systems in cortisol release from human adrenal cells
(2004-05-25)Adrenal steroid hormones (e.g., cortisol) play a pivotal role in the regulation and maintenance of metabolic homeostasis. The secretion of glucocorticoids from adrenocortical cells into ... -
Rolle von löslichen MHC-Klasse I-Molekülen bei der Apoptose sensibilisierter T-Lymphozyten
(2003-06-27)Dendritic cells (DC) are the most potent antigen-presenting cells and may be possible candidates in the immune therapy because of their ability to induce a primary T-cell-dependent immune ... -
Röntgenstrahlen induzierte DNA- Doppelstrangbrüche in säugen Zellen in Abhängigkeit vom Zellzyklus.
(2002-11-25)The present study reports improvements in the neutral comet assay first introduced by (Singh and Stephans, 1997; Olive et al., 1998) to measure radiation induced DNA damage. Different ... -
Steroidhormone in bodengelagertem Skelettmaterial
(2005-11-04)The possible causes of the population explosion in the late 18th Century in Mid-Europe are widely discussed by historians. Without doubt, the population increase can be observed simultaneously ... -
Struktur-Funtionsbeziehung in den spleißosomalen Proteinen des U4/U6•U5 tri-snRNP
(2007-01-29)Subject of this thesis is the splicesosmal U5-particle. The functional relationship of the proteins is investigated by means of limited proteolysis and spectroscopy. Due to the splicesosome's ... -
Studies on the control and function of chromatin fragmentation during apoptosis
(2005-08-10)Apoptosis in eukaryotic cells is often accompanied by chromatin cleavage resulting in nucleosomal fragments. This cleavage is catalyzed by a DNase (named DFF40 or CAD) which is specifically ...