Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Fritz, Hans-Joachim Prof. Dr."

Studies into the structural basis of the DNA uridine endonuclease activity of exonuclease III homolog Mth212

Tseden, Khaliun (2011-05-16)

Mth212, an exonuclease III homolog from the archaeon Methanothermobacter thermoautotrophicus, compensates the lack of a DNA uracil glycosylase (UDG) in this organism by catalyzing direct ...

Use of peptide microarrays for mapping viral b cell epitopes

Abou El Nasr, Ahmed Abd El Wahed Aly Abou El Nasr (2011-03-17)

Mapping targets of antibodies - in particular neutralizing ones - is of great value for monitoring vaccination efficacy as well as for development of novel vaccines and reagents for ...

Biochemische, molekularbiologische und genetische Untersuchungen über strukturelle Voraussetzungen für DNA U-Endonukleaseaktivität in der ExoIII-Familie von DNA Reparaturenzymen

Ber, Svetlana (2010-03-05)

One of the most serious problems in any organism is the spontaneous hydrolytic DNA damage. The problem of U-DNA repair is being intensively studied in thermophilic and hyperthermophilic ...

Investigations into the mode of action of the DNA uridine endonuclease Mth212 of Methanothermobacter thermautotrophicus ΔH

Ciirdaeva, Elena (2010-03-05)

Spontaneous hydrolytic deamination of cytosine to uracil is one of the most frequent DNA modifications during cellular everyday metabolism. To counteract this mutagenic effect, most organisms ...

Directed evolution of novel properties starting from HisF of <i>Thermotoga maritima</i> as a structural scaffold

Ling, Zhenlian (2006-01-24)

tHisF, imidazole glycerol phosphate synthase from hyperthermophilic organism T. maritima, with a (ba)8-barrel structure was used as scaffold for directed evolution of enzymes. The ...

Structural Analysis of a Transactivation Domain Cofactor Complex

Ramakrishnan, Venkatesh (2005-07-29)

Signal Transducers and Activators of Transcription (STAT) proteins were discovered as targets for interferon activation. These proteins are dormant in the cytoplasm until they are activated ...

Kombinatorische Synthese einer Genbibliothek und Analyse ihrer statistischen Struktur

Kansy, Eva (2004-05-14)

Considering calculated parameters and using appropriate mixing ratios of codons during the DNA synthesis a gene library with determined population structure was generated. The partial ...

Evolutive in vitro-Adaption eines thermostabilen, (βα)8-barrel-Proteins an die Katalyse einer abiotischen Reaktion

Schiller, Stina (2004-02-12)

The tHisF, the synthase subunit of the imidazole glycerol phosphate synthase from the hyperthermophilic organism Thermothoga maritima, was used to make the (βα)8-barrel-fold accessible for ...

Expression der CRFR-Gene in Antwort auf Stress und Lernen

Sananbenesi, Farahnaz (2003-05-23)

Learning can be defined as a process by which organisms alter and adapt their behavior to environmental stimuli thereby forming an inner representation of their world. One of the most ...

Gezielte Modifikation sowie Analyse der Bindungseigenschaften des Histidin Bindeproteins aus Escherichia coli und des GCN4 Leucinzippers aus Saccharomyces cerevisiae

Wittmann, Julia (2002-11-27)

The histidine-binding protein (HisJ) belongs to the super-family of soluble periplasmic receptor proteins in gram-negative bacteria like Escherichia coli. HisJ takes part in transloctation ...

Identifizierung und Charakterisierung von thermostabilen Uracil Glykosylasen von Archaeon Methanobacterium thermoautotrophicum und Bakterium Thermus thermophilus

Starkuviene, Vytaute (2002-05-22)

Hydrolytic deamination reactions of cytosine and 5-methylcytosine results in highly mutagenic U/G and T/G mismatches, respectively. These processes are especially pronounced at high ...