Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Engel, Wolfgang Prof. Dr."
Now showing items 1-20 of 49
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Molecular role of Pelota (PELO) in differentiation of embryonic and germ stem cells
(2015-11-05)Pelota (Pelo) is an evolutionary conserved gene, which has been characterized in diverse species. In mouse, Pelo deficiency results in embryonic lethality at early post-implantation stage. The in vitro culture of Pelo-null ... -
Effect of radiation on hepatic fat metabolism in rat and mouse: A role of radiation-induced TNF-α in the regulation of FAT/CD36
(2015-08-13)Radiotherapy is an important method to treat tumors. The positive effects of irradiation on tumoral tissue are thought to be due to the damage of the DNA of tumor cells and the damage of tumor vessels. Radiation as single ... -
miRNA functions in pluripotency and spermatogenesis
(2013-10-23)For quite a long time, non-coding RNAs (ncRNAs) were discriminated and considered as an evolutionary error. In light of this opinion, discovery of small ncRNAs, in particular microRNA (miRNA), which can regulate the gene ... -
Die Rolle der IGF-Achse in Kombination mit anderen Wachstumsfaktor-Signalwegen bei der Resistenz oder dem Ansprechen von kolorektalen Karzinomen auf eine Radiochemotherapie
(2013-10-11)In the Western world cancer represents one of the major health problems. Colorectal cancer (CRC) is the third most common tumor incidence. In advanced disease, in most cases a combined radiochemotherapy (RCT) is performed, ... -
Studying synaptopathies using Mecp2 transgenic mouse models
(2013-09-05)The MECP2 gene is located in the Xq28, which encodes for methyl-CpG binding protein 2 (MeCP2). Mutations in MECP2 gene is the primary cause of postnatal neurodevelopmental disorder, Rett syndrome (RTT) (loss-of-function). ... -
Analysis of coiled coil domain containing 33 protein (CCDC33) and determination of infertility causes in mutant mouse line with the deletion of six germ cell-specific genes
(2013-02-27)Since most cases of male infertility remain idiopathic, analysis of the mechanism in which genes are involved in spermatogenesis control might help to better understand the reasons. This thesis consists of 2 parts concerning ... -
Stage-specific germ cell marker genes function in establishment and germ cell lineage commitment of pluripotent stem cells
(2013-01-15)Germ cells are firmly committed to fulfil the mandate of transmitting genetic and epigenetic information from one generation to the next. Their mysterious characteristics have fascinated biological researchers to study ... -
Novel interaction partners of the chromatin remodeler CHD7, a protein mutated in CHARGE syndrome
(2012-09-14)Summary CHARGE syndrome, an autosomal dominant inherited multiple malformation syndrome is caused by mutations in the chromodomain helicase DNA binding protein 7 gene (CHD7). In 10% of ‘typical’ CHARGE patients and 40-50% ... -
Pluripotency of multipotent adult germ-line stem cells: analysis of apoptotic and epigenetic features
(2012-05-10)Pluripotency is the potential of cells to proliferate incessantly (self-renewal) and to develop into all cell types of the three germ layers as well as to the germ line. Recently established multipotent adult Germ-line ... -
Comparative Analysis of Embryonic Stem Cells and Multipotent Adult Germline Stem Cells at the Level of Transcriptome and Proteome
(2011-04-01)Pluripotency of different stem cell types is a complex biological state which allows the cells to continuously proliferate (self-renewal) but also primes them for differentiation into all ... -
Studies on Expression and Function of Vsig1 Gene
(2011-03-11)The aim of this study was to determine the expression pattern of Vsig1 during testis development and analysis of the conditional Vsig1knockout mouse, transgenic Cyto-Vsig1 and Villin-Vsig1 ... -
Differentiation of Flk-1 positive multipotent adult germline stem cells into endothelial cells in vitro and in vivo
(2011-03-08)Multipotent adult germline stem cells (maGSCs) offer a novel route to cell-based therapy without immune rejection and ethical limitations. The present study showed the generation and expansion ... -
Genetic and functional characterisation of killer cell immunoglobulin like receptors (KIR) of rhesus macaques (Macaca mulatta)
(2011-02-24)This PhD thesis reports the characterisation of the genetic diversity of killer cell immunoglobulin like receptors (KIR) as well as interactions between KIR and MHC class I molecules in the ... -
Charakterisierung von Leupaxin und seiner Interaktionspartner in Karzinomzellen
(2011-02-23)Leupaxin (LPXN) is identified as a protein enhancing the growth of existing TRAMP-tumours and metastasis. Various pathways give evidence of this effect. The overexpression of LPXN in Prostate ... -
Über die funktionelle Analyse des murinen peroxisomalen Testis-spezifischen Gen 1 (Pxt1)
(2010-11-26)Mammalian spermatogenesis is a complex biological process by which diploid spermatogonia differentiate into specialized haploid spermatozoa. Regulation of male gametogenesis involves a ... -
Modulation of Gene Expression of Iron Regulatory Proteins, Hemeoxygenase-1 and Lactoferrin, in Mice Liver and Muscle by Different Cytokines, In Two Models of Acute Phase Reaction.
(2010-05-07)Iron is indispensable to living organisms. Iron homeostasis is orchestrated both at the cellular and the systemic level, and liver plays a central role in the regulation of iron ... -
Functional Analysis of Insl5 and Insl6 Genes and Verification of Interactions between Pelota and its Putative Interacting Proteins.
(2009-11-27)The aims of the study were to determinate expression and function of two members of insulin like family, namely Insl5 and Insl6 and to verify the interactions between PELO and its putative ... -
Impact of iron-deficiency upon behaviour and protein expression in the male mouse with implications for Restless Legs Syndrome
(2009-06-12)Restless legs syndrome (RLS) comprises of both sensory and motor symptoms, observed as an increased pain and periodic jerking movement of the legs. There are two forms of RLS; one ... -
Cellular and Biochemical Analysis of an Outer Dense Fiber Protein 2 (Odf2) Variant and the Endogenous Odf2 / Cenexin in Functional Approaches
(2009-02-11)The genome of a somatic cell is duplicated once every cell - cycle. The centrosome as well as the cytoskeleton plays central roles in orchestrating cell cycle progression and its proper ... -
Funktionelle Analyse von MHC-Klasse-I-Genen der Rhesusaffen (<i>Macaca mulatta</i>)
(2008-09-01)This thesis focuses on the structure and function of rhesus macaque (Macaca mulatta, Mamu) major histocompatibility complex (MHC) class I genes. As the cellular immune response is at least ...