Dokumente Medizin nach Titel
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A cell-type and compartment specific analysis of glutathione and hydrogen peroxide
(2019-07-04)Reactive oxygen species (ROS) have been recognized to play important roles as messenger molecules. They are involved in the etiology and progression of cardiovascular diseases such as myocardial infarction, cardiac hypertrophy ... -
A combination of repurposed drugs reduces the proliferation and viability of glioblastoma cells
(2021-10-01)Background: Glioblastoma multiforme (GBM) is a malignant primary brain tumour with high rates of recurrence. The tumour is characterized by high molecular diversity. A strategy to simultaneously target different oncogenic ... -
A Genome-Wide RNAi Screen for Modifiers of Polyglutamine-Induced Neurotoxicity in Drosophila
(2013-03-15)Spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) belongs to the group of polyglutamine (polyQ) neurodegenerative diseases and is the most prevalent autosomal dominant cerebellar ataxia worldwide. A ... -
A Genome-Wide Screen on Modifiers of Tau-Induced Neurodegeneration Using RNAi-Mediated Gene Silencing in Drosophila
(2011-05-27)Intraneuronal inclusions of Tau protein are a common feature of the so-called Tauopathies. Frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) is one of the Tauopathies ... -
A novel tool for neuronal physiology and pathology: optimization of secondary ion mass spectrometry approaches
(2023-10-05)Secondary Ion Mass Spectrometry (SIMS) is a powerful tool for characterizing the chemical composition of solid samples and thin films, offering high sensitivity and spatial resolution. While initially developed for geology, ... -
ABC-Transporter-Gen-Polymorphismen sind potentielle pharmakogenetische Marker der Ansprechrate auf Mitoxantron in der Behandlung der Multiplen Sklerose
(2012-01-30)Escalation therapy with mitoxantrone (MX) in highly active multiple sclerosis is limited by partially dose-dependent side-effects. Predictors of therapeutic response may result in individualized ... -
Aberrant CDK1 Activity in S Phase Induces Chromosomal Instability by Increasing Mitotic Microtubule Polymerisation Rates in Colorectal Cancer Cells
(2021-05-27)Whole chromosomal instability (W-CIN), one of the major hallmarks of human cancer, is defined as the perpetual gain or loss of whole chromosomes during mitosis leading to the development of heterogeneous karyotypes. W-CIN ... -
Abgelehnte nachträgliche Sicherungsverwahrung gemäß § 66 b StGB: Psychiatrische Prognosegutachten und empirische soziodemografische sowie kriminalbiografische Befunde der Probanden
(2016-01-11)This study examines the recidivism of offenders who are considered to be highly dangerous but have not been in the Preventive Detention that is imposed retrospectively ( § 66b StGB). Due an observation time of 24 months ... -
Abhängigkeit der Segmentkinematik von der Position der Vorlast im Segment L3/L4
(2015-06-04)High resolution 6D-analysis of kinematics in lumbar segment L3/L4. The measuring apparatus imitates physiological movements of the human body in axial rotation, flexion/extension and lateral bending. The position of the ... -
Abhängigkeitsschweregrad, Komorbidität und Kognition im Benzodiazepinentzug
(2013-10-10)Addiction, comorbidity and cognition in Patients with benzodiazepine dependence. -
Ablationsbehandlung epikardialer akzessorischer Leitungsbahnen über das Koronarvenensystem bei Kindern und Jugendlichen
(2024-01-24)This retrospective data analysis was used to collect data from 24 patients ≤ 18 years who underwent ablation treatment of accessory pathways within the coronary venous system in Göttingen between October 2002 and December ... -
Abschliff von Knochenzement bei aseptischer Lockerung zementierter Femurschäfte (Typ CF-30) - Eine Volumenabschätzung anhand von Reoperationspräparaten
(2011-09-15)Aims of the work: The aseptic loosening as a late complication after prosthetic implantation increases due to the prolonged life expectancy and the young age of patients who get an prosthesis ... -
Abseits der Effektivität – Wie geht es Patienten unter Lipidapheresetherapie?
(2014-01-16)OBJECTIVE: Lipoprotein apheresis (LA) is applied to patients with refractory hyperlipidemia as secondary prevention. While we have a large knowledge about the effectiveness and safety, there is a lack of valid surveys of ... -
Accumulation of single-stranded DNA in tumour cells as a result of replicative stress
(2018-01-15)Cells are constantly subjected to DNA damaging agents like reactive oxygen species, UV light or, in the case of cancer cells, chemotherapeutic drugs. All these agents can lead to replicative stress, meaning that the most ... -
Activation of murine microglial cells by muramyl dipeptide alone and in combination with Toll-like receptor agonists
(2014-09-25)Meningitis, meningoencephalitis and sepsis are severe diseases causing many deaths all over the world every year. Escherichia coli (E. coli) is the most common Gram-negative bacterium causing neonatal meningitis and sepsis ... -
Activin A und Follistatin bei bakteriellen Infektionen - Der Einfluss von Activin A auf Mikrogliazellen in vitro und der Einfluss von Follistatin auf den Verlauf einer E. coli-K1-Sepsis im Mausmodell
(2012-10-01)High concentrations of Activin A and Follistatin can be found in the cerebrospinal fluid (CSF) of patients with bacterial meningitis. Patients suffering from a sepsis have increased concentrations of Activin A and Follistatin ... -
Activity-dependent turnover of the Perineural Extracellular Matrix
(2024-04-05)The different molecules present in the extracellular space of the brain make-up the perineural extracellular matrix (ECM). One of the specializations of the perineural ECM, the perineural nets (PNNs), are lattice-like ... -
Adaptive designs for clinical trials in cardiovascular diseases
(2018-12-07)Cardiovascular diseases are diseases of the heart and blood vessels constituting a major cause of death and disability worldwide. Cardiovascular drug development aims to deliver efficacious drugs to address the public ... -
Adäquate und inadäquate Schockabgaben implantierbarer Kardioverter- Defibrillatoren bei Kindern, Jugendlichen und Patienten mit einem angeborenen Herzfehler
(2021-02-11)In pediatric cardiology and cardiology of adults with congenital heart disease, indication for implantation of an implantable cardioverter-defibrillator (ICD) is often based on underlying diseases like primarily electrical ... -
Additiver Mikroglia-vermittelter Neuronenschaden durch β-Amyloid und bakterielle Toll-like-Rezeptor-Agonisten in primären murinen Mikroglia-Neuronen-Kokulturen. Entwicklung eines Auswertungsalgorithmus zur Quantifizierung des Neuronenschadens mit Hilfe einer Software zur objektorientierten Bildanalyse
(2012-06-06)Activated microglia is considered to be involved in the progression of Alzheimer´s dementia (AD). We investigated the effect of Aβ40 and exogenous agonists of TLR1/2 [Pam3CSK4] and TLR4 [LPS] on neurons in primary ...