Dokumente Medizin nach Titel
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Tabakentwöhnung als Ausbildungsziel im Medizinstudium
(2022-05-12)Smoking is associated with numerous diseases. The success rate of smoking cessation is enhanced by counselling; however, this is seldom carried out by physicians. A lack of training in undergraduate medical education was ... -
Tageszeitabhängige Abweichungen der statischen und dynamischen Okklusion
(2021-04-20)Introduction. Occlusion, i.e. the sum of contacts between teeth of the maxilla and mandible, plays a decisive role in the pathogenesis of temporomandibular disorders (tmd) and in restorative therapy. Static and dynamic ... -
Target recognition of an RNA methyltransferase
(2024-04-18)To date more than 150 different RNA modifications have been detected in cellular RNAs and are collectively termed the epitranscriptome. RNA modifications occur at different positions within each of the four bases or the ... -
Targeting and Elimination of T Cell Subpopulations by Chimeric Antigen Receptor-modified T Cells
(2021-08-10)Chimeric antigen receptors (CARs) demonstrated a high potential for the elimination of tumor cells in cancer immunotherapy. The first successful application of CAR-expressing T cells aimed at the elimination of B cells in ... -
Targeting cell invason signaling to impede breast cancer metastasis
(2020-02-25)Breast cancer cell invasion is the initial step of the invasion-metastatic cascade, and approximately 90 % of all cancer-related deaths are due to currently incurable cancer metastasis (1). Unique features of tumor ... -
Targeting JAK/STAT signalling for sensitization of colorectal cancer cells to chemoradiotherapy
(2021-07-08)Despite ever-evolving treatment and screening procedures, Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide. Preoperative chemoradiotherapy (CRT), followed by standardized surgical resection ... -
Targeting MDM2, the antagonist of the tumor suppressor p53
(2018-09-19)p53 is one of the most extensively studied tumor suppressor proteins, and its gene is mutated in 50% of human cancers. Stress signals activate p53 and its transcriptional machinery which lead to cell-cycle arrest, apoptosis ... -
Targeting the Hedgehog and PI3K/AKT/mTOR signaling pathways in rhabdomyosarcoma
(2018-12-18)Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS, and especially the embryonal subtype (ERMS), show activation of Hedgehog (HH) signaling. In patients with Gorlin syndrome, ... -
Tau- und S-100b-Protein in der Differenzialdiagnose der bakteriellen Meningitis
(2012-09-14)In spite of intensive efforts towards an improved diagnostic and therapy the bacterial meningitis still shows a clinical picture to be taken seriously which ends for the affected patients not seldom with secondary damages ... -
Technische und biologische Komplikationen von einteiligen Zirkonoxidaufbauten und Vollkeramikkronen auf Einzelzahnimplantaten: 5-Jahresergebnisse einer retrospektiven klinischen Studie
(2014-08-14)This retrospective study evaluates the clinical outcomes of prefabricated one-piece zirconia abutments and all ceramic crowns in the anterior region over an observation period of five to seven years with closer examination ... -
Telemetrisch kontrollierte Blutdrucktherapie bei Patienten mit unzureichend eingestelltem Hypertonus
(2010-08-13)Introduction: Arterial hypertension represents the most common widespread disease because of its high prevalence and its mortality. Yet only approximately 30% of patients suffering from ... -
TET3 IMPACTS CARDIAC FIBROSIS PARTIALLY VIA REGULATION OF DNA DAMAGE RESPONSE
(2020-02-12)Activation and proliferation of cardiac fibroblasts are the prime mediators of cardiac fibrosis. Existing studies show that ROS and inflammatory cytokines produced during fibrosis not only signal proliferative stimuli but ... -
TGFbeta und Fibrose der Haut
(2021-06-29)Systemic sclerosis (SSc) is a fibrotic disease characterized by TGFβ-mediated differentiation of dermal fibroblasts to contractile myofibroblasts leading to accumulation of extracellular matrix proteins. Multiple studies ... -
TGFβ mediated chromosomal instability in human colorectal cancer cells
(2023-06-28)Chromosomal instability (CIN) is a major hallmark of human cancer and is defined as persistently high rate of the generation of chromosomal aberrations leading to genetic variability, tumour heterogeneity and tumour ... -
The association between stress and blood pressure in a sample from the German Health Interview and Examination Survey for Adults (DEGS1)
(2015-07-14)Objective: Psychosocial stressors have long been studied for their contribution to the development of hypertension, but their role remains controversial. In this post-hoc analysis of the nationwide German Health Interview ... -
The Development of Premortal Diagnostic Test for a-Synucleinopathies in Cerebrospinal Fluid and Blood
(2024-01-26)Synucleinopathies represent a group of neurodegenerative disorders characterized by the accumulation of abnormal α-synuclein protein aggregates in the central nervous system. Accurate and early diagnosis is crucial for ... -
The DNA damage kinases MK2, Chk1 and the chromatin remodeling factor CHD8 determine the cellular outcome after replicative stress and DNA damage
(2021-03-26)DNA damage occurs and accumulates in every cell and is cause and consequence of cancerogenesis. Massive induction of exogenous DNA damage has its use in chemotherapy as it causes growth arrest and apoptosis in malignant ... -
The effect of acute evoked muscular pain at the lower back on motion capture and surface EMG during a repetitive movement task
(2022-05-24)Low back pain (LBP) is one of the most common reasons for consulting health care services. Since up to 80% of all people experience LBP at least once in their lifetime, it is of great interest to understand the underlying ... -
The effect of apomorphine on anodal tDCS-induced cortical plasticity in the human motor cortex
(2018-11-05)The aim of this thesis was to study the effect of apomorphine on non-focal anodal tDCS-induced plasticity and thus further examine the influence of the dopaminergic system on motor cortex plasticity in humans. In a randomized ... -
The effect of dimethyl fumarate on phenotype and function of B lymphocytes in MS patients
(2021-04-09)Although the oral agent DMF was approved for the treatment of RRMS in 2014 and demonstrably reduces relapse rates and disability progression, its effect on B cells, which are now thought to be major contributors to disease ...