Dokumente Medizin nach Titel
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rAAV-based gene therapy for molybdenum cofactor deficiency type B
(2015-06-29)Molybdenum cofactor (MoCo) deficiency type A is thus far only one curable type of MoCo deficiency. In the present study, a mouse model for MoCo deficiency type B (Mocs2-/-) was generated, characterised and used for preclinical ... -
Radio(chemo)therapie bei älteren Patient:innen mit Kopf-Hals-Tumoren – eine retrospektive Untersuchung zur Erfassung von Einflussfaktoren auf Überleben und Toxizität
(2023-11-02)Locally advanced head and neck squamous cell carcinoma (HNSCC) is often treated with surgery followed by postoperative radiochemotherapy (RCT). With the general increase in life expectancy, the number of elderly HNSCC ... -
Radio(chemo)therapie des Zervixkarzinoms – Klinische Ergebnisse mit intensitätsmodulierter Rotationsbestrahlung und konventioneller 3D-Bestrahlung im Vergleich
(2020-08-24)Abstract Purpose Intensity-modulated radiotherapy (IMRT) for cervical cancer yields favorable results in terms of oncological outcomes, acute toxicity, and late toxicity. Limited data are available on clinical results ... -
Radioimmuntherapie bei diffus großzelligen B-Zell-Lymphomen
(2012-12-12)The present study investigated the practicability and safety of radio-immunotherapy (RIT) in diffuse large B-cell-lymphomas (DLBCL) in the clinical everyday use and outside randomised clinical studies on basis of ... -
Radiologische Bildgebung bei Primären Sarkomen der Niere: eine multizentrische Studie
(2023-03-17)Primary renal sarcomas are very rare renal malignancies of mesenchymal origin which comprise a variety of histological subtypes. They belong to the heterogeneous group of soft tissue sarcomas which can occur in variable ... -
Radiologische Evaluation der Amelioration des Implantatbettes durch Polylaktide. Eine Pilotstudie am Göttinger Minischwein.
(2017-07-20)The dental implantology currently delivers the best prosthetic rehabilitation of missing teeth. The reliable succesful restorations made the treatment accessible for vast group of patients. Osteoporosis, a disease prevalent ... -
Radiologische Evaluation der anatomischen Möglichkeit zur Implantation von Pedikelschrauben im Bereich des kraniozervikalen Übergangs sowie der oberen Halswirbelsäule
(2023-08-21)Instabilities of the craniocervical junction and the upper cervical spine may require dorsal stabilization of the spine to prevent neurological complications. We aimed to analyze the number of patients in which pedicle ... -
Radiologische Querschnittsstudie zur Qualitätsverbesserung von Panoramaschichtaufnahmen mittels Zungenrepositionsmanöver
(2008-12-10)Objective: The purpose of this study was to evaluate the use of the tongue repositioning manoeuvre (TRM) during panoramic radiography so as to avoid the tongue shadow error. Study Design: ... -
Radiomorphometrische Untersuchung der Knochenregeneration in vivo durch kombinierte Freisetzung von VEGF und BMP aus den PDLLA/CaCO3-Komposit-Scaffolds.
(2021-02-22)Bone regeneration of critical-size defects requires ideal release on time of growth factors. The aim of the present in vivo study on male Wistar rats was to improve bone regeneration in mandibular defects of critical-size ... -
Randomisierte, kontrollierte Parallelgruppenstudie zur Untersuchung der Wirksamkeit der manuellen Lymphdrainage und klassischen Massage zur Prophylaxe der Migräne mit und ohne Aura
(2012-01-04)Methods of physical therapy for the prophylaxis of migraine, are often used although, so far not been adequately investigated. The aim of this study is to investigate whether treatment with ... -
Randschlussuntersuchung von Kompositfüllungen unter Einfluss von Brauchwasserdesinfektionsmitteln zahnärztlicher Behandlungseinheiten
(2013-11-29)The border seal of resin composite fillings under the influence of disinfectants was investigated after dye penetration with methylene blue. One hundred and sixty human molars were divided in four different groups of ... -
Ranibizumab for Branch Retinal Vein Occlusion Associated Macular Edema Study (RABAMES) - Eine dreiarmige klinische Studie zur Wirksamkeit von Ranibizumab (Lucentis®) im Vergleich zur alleinigen GRID-Laserkoagulation und einer Kombination aus beiden Therapien zur Behandlung des chronischen Makulaödems nach retinalem Venenastverschluss
(2012-12-20)The Ranibizumab for Branch Retinal Vein Occlusion Associated Macular Edema Study (RABAMES) investigated effectiveness and safety of intravitreal applied ranibizumab and grid laser coagulation as well as a combination of ... -
Reaktive Astrozytenveränderungen in Multiple-Sklerose-Läsionen: Morphologische und immunhistochemische Analyse unter Berücksichtigung verschiedener Läsionsaktivitäten und immunpathologischer Subtypen
(2011-06-15)Multiple sclerosis (MS) is a heterogeneous disease characterized by demyelination, inflammation, axonal loss, and astrogliosis. However, the role of astrocytes in the pathogenesis of MS ... -
Die Reaktivierung der FMR1-Transkription in Fibroblasten von Patienten mit Fragilem-X-Syndrom durch Methotrexat
(2014-12-16)The characteristical phenotype of patients with fragile X syndrome is caused by a loss of FMRP expression. In this connection a DNA hypermethylation of the promotor region leads to transcriptional silencing of the FMR1 ... -
Real time cAMP dynamics in the vicinity of phospholemman in healthy and failing cardiomyocytes
(2016-08-16)The ubiquitous second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is a crucial regulator of cardiac function and disease. It is known that cAMP signaling is mediated by discrete functional microdomains each ... -
Real time visualization of cGMP and cAMP dynamics in intact adult cardiomyocytes using new transgenic mice
(2015-01-26)cAMP and cGMP are important second messengers in the cardiovascular system. Previously, it has been demonstrated that the cardiac ryanodine receptor (RyR2) forms a microdomain associated with key contributors of cAMP ... -
Rectus-internus-Fadenoperation versus Rectus-internus-Rücklagerung beim frühkindlichen Schielsyndrom
(2016-02-22)Background: Beside combined recess-resect procedures, bilateral medial rectus recession and bimedial posterior fixation sutures and also a combination of both are common in surgery for infantile esotropia. We compared ... -
Redox regulation of protein phosphatase-1 and ER stress regulation of connective tissue growth factor in cardiomyocytes
(2017-06-28)Heart failure is one of the most common causes for morbidity and hospitalization in the western civilization. The prognosis is still poor and new therapies are needed. For decades, variations in phosphorylation and redox ... -
Redox regulation of ryanodine receptor/Ca2+ release channels by NOX enzymes in hypertrophy and heart failure
(2022-05-10)Cardiac function is characterized by a rhythmic sequence of contraction and relaxation of cardiomyocytes driven by tightly controlled intracellular calcium release events. The cardiac ryanodine receptor type 2 calcium ... -
Reduktion der Gesamtbiopsieanzahl und Verbesserung der Tumordetektionsrate in der MRT/TRUS-Fusionsbiopsie der Prostata unter Verwendung eines optimierten Computeralgorithmus
(2023-06-28)Prostate carcinoma is the most frequently diagnosed male carcinoma in Germany. For patients, it is crucial to detect clinically significant malignancies. Here, the prostate biopsy is the method of choice. The aim of this ...