Dokumente Medizin nach Titel
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GABA(b)-Rezeptor-vermittelte Modulation an Martinotti-Zellen im primär somatosensorischen (Barrel-)Kortex der Maus
(2022-03-31)Under physiological conditions the brain is subject to continuous remodelling processes. In this case exizitation und inhibitation - and especially their balance - are important factors. Neuronal plasticity makes the brain ... -
Galectin-3 bei Patienten mit Herzinsuffizienz mit erhaltener Ejektionsfraktion (HFpEF) - Klinische Assoziationen, Einfluss einer Aldosteron-Rezeptor-Blockade und prognostische Bedeutung - Ergebnisse der Aldo-DHF- Studie
(2015-01-29)Half of patients with heart failure suffer from heart failure with preserved ejection fraction and cardiac fibrosis is believed to be a major pathophysiological component in this condition. Galectin-3 is a marker of ... -
Gallengangskomplikationen und Gallengangsanastomosenstenosen nach orthotopen Lebertransplantationen - Retrospektive Untersuchung von 220 Lebertransplantationen der Universitätsmedizin Göttingen
(2016-02-17)Objective: Over 40y passed since the first liver transplantation has been performed. After the development of the immunosuppressant Cyclosporin A significant increase in the survival rates up to 60-70% could be achieved. ... -
Gastrointestinale Motilität und infektiologischer Verlauf bei polytraumatisierten Patienten mit und ohne Schädel-Hirn-Trauma
(2021-09-09)Retrospective analysis if gastrointestinal dysfunction in polytrauma patients increases the risk of sepsis. The medical records of 100 polytrauma patients (ISS ≥ 16, lying on ICU between 2010 and 2014) have been searched ... -
Gastrointestinale Motilitätsstörungen als Risikofaktor für Sepsis – eine retrospektive Untersuchung bei Patienten mit isoliertem Schädel-Hirn-Trauma
(2022-11-07)Referring to the initial hypothesis of "Gut-as-a-motor-of-sepsis," this study aims to elicit reasons for systemic inflammation in critically ill patients with traumatic brain injury. Statistical evidence that certain ... -
Gedanken der integrativen Psychotherapie im religiös-philosophischen Werk Martin Bubers
(2017-12-14)The following thesis aims to present a novel reception of Martin Buber’s thought regarding the theory and practice of psychotherapy. Its goal is to describe some of the modern views on integrative psychotherapy and its ... -
Gefahren von Gefäßverletzungen bei schwerem Beckentrauma
(2022-08-11)Pelvic fractures with concomitant vascular injuries are rare events. 25% of severely injured patients experience a relevant pelvic injury. 3-9% of these have a significant vascular injury. The aim of the study was to develop ... -
Genauigkeit der Implantatlage und perioperativer klinischer Verlauf nach konventioneller, minimalinvasiver und Roboter-assistierter Implantation von Pedikelschrauben
(2014-01-27)Robotic-guided and percutaneous pedicle screw placement are emerging technologies. We here report a retrospective cohort analysis comparing conventional open to open robotic-guided and percutaneous robotic-guided pedicle ... -
Genauigkeit von Gesichtsbogen und zweidimensionaler Kephalometrie in Zeiten dreidimensionaler computergestützter Dysgnathietherapie
(2020-11-09)Conventional planning method in orthognathic surgery is based on two-dimensional X-rays and by face-bow transfer mounted plaster models of the maxilla. Thanks to the introduction of three-dimensional imaging (CBCT) and ... -
Gene Transfer Into the Inner Ear
(2019-10-21)In humans, in whom speech and speech perception is essential for communication and social interaction, deafness is a severe disorder. One of the genetic non-syndromic forms is the autosomal recessive nonsyndromic deafness ... -
Gene-Environment Interaction and Extension to Empirical Hierarchical Bayes Models in Genome-Wide Association Studies
(2014-07-24)There are over 100,000 human diseases of which only around 10,000 are known to be monogenic, resulting from modification in a single gene. Many multifactorial diseases, such as cancer and lung cancer in particular, are ... -
Gene-expression control in early and late-onset dementia
(2022-10-05)Mutations in genes that control epigenetic gene expression, especially the machinery that controls Histone 3 lysine 4 (H3K4me) methylation, are over-represented in intellectual disability disorders. It is mediated by both ... -
Gene-Set Meta-Analysis to Discover Molecular-Biological Pathways Associated to Lung Cancer
(2017-06-09)During the last two decades the search for risk factors of many human diseases turned into a new direction, since it got feasible to gauge the human genome. Genome-wide association studies (GWAS) were carried out to identify ... -
Generierung von Antikörper-Bibliotheken und Selektion von Antikörpern gegen die Integrine αvβ5 und α5β1 mittels Phagen-Display-Technologie
(2008-10-23)Angiogenesis, the formation of new blood vessels, plays a major role in controlling growth and survival of tumours. As cell adhesion molecules, integrins directly influence the function and ... -
Genetic modification in CPVT patient specific induced pluripotent stem cells with CRISPR/Cas9
(2019-12-02)CPVT is a genetic cardiac disorder leading to sudden cardiac death in young patients without structural abnormalities of the heart. Abnormal Ca2+ handling in CMs causes severe arrhythmia during physical or emotional stress ... -
Genetic polymorphisms in genes regulating renal ion excretion and diuretic drug effects
(2014-07-17)Regulation of human salt and fluid homeostasis is of basic biological importance. Kidney functions allow surviving under a wide variety of conditions with high or low salt diets and with high or low intake of fluids, even ... -
Genetisch bedingte Variabilität der Expression von Genen des TGFß-Signalwegs und deren Bedeutung für die Zellvitalität: Untersuchungen in T-Lymphozyten, immortalisierten B-Lymphozyten und Fibroblasten
(2013-01-29)The TGFbeta pathway is involved in a huge number of biological functions and, hence, relevant for a plethora of clinical disorders. A major function of this pathway is its contribution to fibrotic conditions as it may ... -
Genetische Creutzfeldt-Jakob-Krankheit in Deutschland (1993-2010) - Charakterisierung dreier häufiger Mutationen in Abgrenzung zur sporadischen Creutzfeldt-Jakob-Krankheit und eine klinische Darstellung von seltenen Mutationen
(2014-04-01)This dissertation presents common and rare genetic CJD in their clinical presentation. The aim was to find a differentiation between the sporadic CJD and the common genetic CJD E200K and V210I. The other part was a clinical ... -
Genetische Determinanten in der Genese und Strahlentherapie des Prostatakarzinoms
(2015-03-13)Prostate cancer ranks first in newly diagnosed cancer cases wordwide. Radiotherapy in curative intention is a suitable treatment for many different stages of the disease. Transformal Growth Factor beta (TGFB) has been shown ... -
Genetische Marker bei hausärztlichen Patienten mit oraler Antikoagulation
(2004-02-11)Background:In patients on oral anticoagulation with warfarin, genetic variations of the cytochrome P 450 - CYP2C9 have recently been associated with very low warfarin requirements. Patients ...