Dokumente Medizin nach Titel
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C-terminally truncated Amyloid-β peptides in Alzheimer’s dementia: Deposition of Aβ37, Aβ38, and Aβ39 in the brains of patients with sporadic and familiar Alzheimer’s dementia and in transgenic mouse models.
(2018-01-24)Alzheimer's dementia is a devastating neurodegenerative disease characterized by profound neuropathological changes of the brain. Imbalances in the production of aggregation-prone Amyloid-Beta Peptides are believed to play ... -
Cancer cell death by mitotic failure upon combined kinase inhibition
(2022-06-02)Cancer cells are prone to replicative stress to a greater extent than healthy cells are. Thus, replicative stress might be a way to target cancer cells in a more specific way than conventional chemotherapeutics do. According ... -
Cancer drugs targeting DNA replication: Molecular strategies to enhance specificity and efficacy
(2020-07-10)The DNA molecule stands at the center of cancer origin and treatment. Cancer cells are addicted to DNA mutations and DNA replication, therapeutic non-responders are often based on the rate of mutations and ability to ... -
Candida-Blutkulturisolate in Deutschland und Österreich
(2008-08-28)Cotent of this thesis are 1. establishment of the mikrodillution suscebtibilitytesting for yeasts as defined by the CLSI (National Committee for Clinical Laboratory Standards 2002) for the NRZSM (National Reference ... -
Cannabinoid-basierte Therapie in einem Modell für die sporadische Alzheimer-Erkrankung
(2022-09-14)The endocannabinoid system (ECS) is involved in several metabolic processes of the human body and has among others a neuroprotective and anti-inflammatory effect on the central nervous system. Tetrahydrocannabinol (THC) ... -
Cannabinoidrezeptor CB1 und Endothelin-B-Rezeptor: Interaktion im Hippokampus
(2008-05-09)Cell membrane standing receptors are known to mediate antiapoptotic signalling in the brain of juvenile rats. This thesis illuminates the interaction between two cell membrane standing receptors CB1 and ET-B in the brain ... -
Cardiac and fibroblastic properties after HIF-1α stabilization
(2015-06-01)The cellular oxygen sensing prolyl-4-hydroxylase domain proteins (PHDs) are essential regulators of the α-subunit of hypoxia-inducible transcription factors (HIFs) which are known to induce a variety of genes affecting ... -
Cardiac fibroblast phenotype regulation in engineered connective tissues with a special focus on ER adaptation and stress
(2023-03-23)Cardiovascular diseases cause adverse myocardial remodeling due to cardiomyocyte loss and modifications to the extracellular matrix (ECM), which can ultimately lead to contractile dysfunction and pathological cardiac ... -
Cardiac Looping und die frühe Topogenese der AV-Region: Untersuchung an Hühnerembryonen
(2017-08-10)The early embryonic heart is a tubular structure that forms by merging of left and right heart fields (HF) along the midline of the dorsal pericardial wall. During HF merging, the initially linear heart tube elongates and ... -
Cardiac microvascular dysfunction in diabetes mellitus: elucidation of molecular determinants and therapeutic targets
(2023-03-09)Microvascular dysfunction is a pathological hallmark of the diabetic myocardium, and is central to the etiology of diabetes-associated cardiac events. Herein, previous studies highlighted the role of the vasoactive micro-RNA ... -
Cartilage Adjacent Subchondral Bone in Ageing and Disease as a Diagnostic and Therapeutic Target
(2021-05-06)Osteochondral unit is emerging as a focal point in osteoarthritis (OA) research, with subchondral bone (SB) attracting more attention as a critical contributing factor to the initiation and progression of OA. In particular, ... -
Cartilage oligomeric matrix protein in der Pathogenese der Arthrosis deformans
(2007-02-12)As a member of the thrombospondin gene family, cartilage oligomeric protein (COMP) is found mainly in the extracellular matrix often associated with cartilage tissue as well as synovia and ... -
CD30 Expression bei Patienten mit einer Mycosis fungoides unter Berücksichtigung der inter- und intraindividuellen Variabilität sowie histologischen und klinischen Parametern
(2023-02-03)Aim of the study: CD30 expression in mycosis fungoides is heterogeneous and mostly not comparable. CD30 is a therapeutic target and a misinterpretation of this biomarker can influence therapy. The study focused on the ... -
CD4+ epidermale Zellen: Nachweis und Charakterisierung in humaner und muriner Epidermis
(2021-05-20)Basal cell carcinoma (BCC) is the most common tumor entity in human skin. Its development is often closely related to overactivation of the Hedgehog (Hh) pathway by mutation of the tumor suppressor Patched (Ptch). Preliminary ... -
Cell-cell communication between chondrocytes and osteoblasts through miR-221-3p loaded extracellular vesicles
(2022-08-30)Osteoarthritis (OA) is a whole joint disease manifested by cartilage degeneration and subchondral bone remodeling, and bone-cartilage communication plays a vital role in the disease progression with the existence of ... -
Cellular and subcellular analysis of peripheral neuropathy caused by peroxisomal dysfunction in mice
(2016-11-09)Fast signal propagation and long-term integrity of myelinated axons rely on precise axo-glial interactions. A role for myelin-associated peroxisomes in facilitating axonal support by glial cells was demonstrated in a mouse ... -
Cellular and transcriptional profiling of hypoxic cells in the brain
(2021-07-08)Hypoxia is a critical regulator of the hypoxic response driving neurodevelop-ment, angiogenesis, hematopoiesis, and tissue regeneration. In the central nervous system, oxygen is a fundamental constituent of cellular ... -
Cellular immunotherapy of pancreatic ductal adenocarcinoma: Discovery and evaluation of novel target candidates
(2021-03-19)Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor prognosis and limited treatment options. In recent years, chimeric antigen receptor (CAR) T cells have achieved remarkable success in the ... -
Cellular prion protein in Alzheimer’s disease: Molecular insights and behavior implications
(2024-01-11)Alzheimer’s disease (AD) poses a substantial and increasing challenge, particularly due to our aging population, and its underlaying pathophysiology remains a topic of ongoing debate. Cellular prion protein (PrPC) has ... -
Cellular response to compartmentalized redox alterations
(2022-08-24)Reactive oxygen species (ROS) were considered only as toxic and unavoidable by-products of aerobic cell life in the past. Nevertheless, their significance for cellular signalling is currently widely accepted and extensively ...