Browsing Human- und Zahnmedizin by Advisor "Zerr, Inga Prof. Dr."
Now showing items 1-20 of 32
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14-3-3-Isoformen im Liquor cerebrospinalis bei Patienten mit verschiedenen molekularen Subtypen der sporadischen Creutzfeldt-Jakob-Krankheit
(2012-05-29)With an incidence of 1-2/1 million inhabitants sporadic Creutzfeldt-Jakob disease belongs to the rare transmissible spongiform encephalopathies caused by prions leading to spongiform degeneration of the brain and consecutively ... -
Analyse der Diagnosekriterien der Creutzfeldt-Jakob-Erkrankung in Deutschland
(2021-11-29)The Creutzfeldt-Jakob disease (CJD) is the most common prion disease. With an incident of 1.5 cases per 1,000,0000 inhabitants in Germany around 120 people (97% of all prion disease cases) are diagnosed with this disease ... -
Analyse der Proteinexpression zur Untersuchung der physiologischen Funktion des zellulären Prionproteins (PrPc)
(2012-01-04)The definite physiological role of the cellular prion protein (PrPc) remains still unclear. On the one hand there is ample in vitro and in vivo evidence suggesting a neuroprotective role ... -
Analyse neuropsychologischer Ausfallprofile bei zerebraler Mikroangiopathie
(2013-09-27)Introduction As the population gets older dementia as a disease of the elderly has to be faced more often. After Alzheimer's dementia (AD) cerebral small vessel disease (CSVD) is the most frequent cause of cognitive ... -
Auswirkungen kardiovaskulärer Risikofaktoren sowie verschiedener Vor- und Begleiterkrankungen auf den Verlauf der Alzheimer-Demenz
(2021-06-22)Alzheimer’s disease is the most common form of dementias. Among patients with Alzheimer’s disease different rates of progression have been observed, not knowing which risk factors could lead to faster cognitive decline. ... -
Biomarker in der Diagnostik und Differentialdiagnostik der vaskulären Demenz bei zerebraler Mikroangiopathie
(2019-06-27)AIMS AND BAKCGROUND: Besides Alzheimer’s disease (AD), Vascular dementia (VD) caused by cerebral small vessel disease (CSVD) is one of the most common causes of dementia but differential diagnosis, especially the ... -
Charakterisierung von Prädiktoren rapid-progressiver Verläufe des M. Alzheimer
(2016-07-12)Alzheimer´s Disease (AD) is a neurodegenerative disorder, whose causes still have to be elucidated. The courses of the disease are heterogen, and rapid progresses were discribed. The data about risk factors and predictors ... -
Doxycyclin bei der sporadischen Creutzfeldt-Jakob-Krankheit
(2011-04-04)Sporadic Creutzfeldt-Jakob-Disease (CJD) is a rare neurodegenerative disorder that belongs to the group of prion diseases. The central pathological event in CJD is discussed to be the ... -
Einfluss der Überexpression des zellulären Prionproteins auf ischämisch induzierte neuronale Schädigung in vivo
(2010-12-02)The purpose of this study was to elucidate the role of PrPC overexpression in ischemic brain injury in vivo. PrPC overexpressing (TG35) and wild type (WT) mice were subjected to a 90-minute ... -
Erstsymptom, Erstdiagnose und ärztlicher Erstkontakt bei Patienten mit sporadischer Creutzfeldt-Jakob-Krankheit in Deutschland
(2014-02-10)Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare, neurodegenerative disorder. To date, only few studies exist about the initial stadium of this disease. The aim of this study was to describe a maximum of two ... -
Genetische Creutzfeldt-Jakob-Krankheit in Deutschland (1993-2010) - Charakterisierung dreier häufiger Mutationen in Abgrenzung zur sporadischen Creutzfeldt-Jakob-Krankheit und eine klinische Darstellung von seltenen Mutationen
(2014-04-01)This dissertation presents common and rare genetic CJD in their clinical presentation. The aim was to find a differentiation between the sporadic CJD and the common genetic CJD E200K and V210I. The other part was a clinical ... -
Genetische Polymorphismen und Progressionsgeschwindigkeit der Alzheimer-Demenz
(2013-10-17)Genetic influences are important for the aetiology of Alzheimer's disease (AD). In recent years numerous candidate genes were discovered which showed a significant association with AD in genome-wide association studies ... -
Gesamt-Tau, pTau, pTau rel, Beta-Amyloid 1-42 und 1-40 sowie Transthyretin in der Differentialdiagnostik neurodegenerativer Erkrankungen
(2022-11-01)New criteria have been published by the National Institute on Aging (NIA) and Alzheimer Association (AA) to define Alzheimer’s disease through the ATN classification system. The ATN classification system is based on ... -
Gibt es einen Zusammenhang zwischen Major Depression und Autoimmunthyreoidits oder anderen Erkrankungen der Schilddrüse?
(2008-09-24)In the present study we tried to figure out a relationship between Major Depression (after DSM-IV criteria) and thyreoid diseases, especially autoimmune thyreoiditis.For fourteen month we ... -
Heterogenität von Prionprotein-Isoformen im Liquor cerebrospinalis von Patienten mit verschiedenen Typen von Prionenerkrankungen: Eine Charakterisierung unter Betrachtung zwölf monoklonaler PrP-Antikörper
(2022-01-11)The cellular prion protein is a multifunctional, evolutionarily highly conserved and ubiquitously expressed protein. It goes through a number of modifications during its post-translational processing, resulting in various ... -
Idiopathisches Parkinson Syndrom und a-Synuclein im Liquor: Bio- und Prognosemarker für Kognition, Krankheitsverlauf und depressive Symptomatik?
(2022-10-18)Bradykinesia, tremor and rigor are the main clinical features by which Parkinson’s Disease (PD) has been diagnosed clinically since the first describer, James Parkinson. A diagnosis-supporting biomarker does not exist yet. ... -
Immunologisches Profil und PrPC-Expression von Patienten mit subkortikaler vaskulärer Enzephalopathie und vaskulärem kognitivem Impairment
(2017-03-02)The impact of vascular cognitive impairment (VCI) in society is increasing. Subcortical vascular encephalopathy (SVE) is the most common cause of VCI and is manifested mainly by White Matter Lesions (WMLs) and clinical ... -
Klinische und diagnostische Charakteristika des VV2-Subtyps der sporadischen Creutzfeld-Jakob-Krankheit
(2011-10-05)Until now six molecular subtypes of sporadic CJD (sCJD) have been identified showing differences regarding the disease course, clinical symptoms and sensitivity to diagnostic tolls. Clinical ... -
Klinische und diagnostische Eigenschaften der sporadischen Creutzfeldt-Jakob-Krankheit bei Patienten mit positiver Familienanamnese für Demenz oder Morbus Parkinson
(2016-06-16)OBJECTIVE It was suggested that the cause of sporadic Creutzfeldt-Jakob disease (sCJD) is a spontaneous change in configuration of the prion protein. The acceptance of the influence of the misfolded protein chains which ... -
Liquormarker Aß 1-42, T-Tau und P-Tau in der Differenzialdiagnostik der Demenzen
(2014-07-14)A correct diagnosis is not always easy to obtain in case of neuro degenerative diseases. Besides clinical appearance and neuro imaging especially the analysis of the cerebrospinal fluid (CSF) is helpful if results are ...