Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Hardeland, Rüdiger Prof. Dr."
Now showing items 1-20 of 27
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Die Übernutzung nicht valider Ratschläge: Warum schlechte Ratschläge über Gebühr berücksichtigt werden
(2011-01-06)Advice utilization during judgment and decision-making is an integral part of everyday life. The most stable finding in the literature on advice taking is that judges tend to place too much ... -
Hilfeverhalten und Zivilcourage: Ein Vergleich von antizipiertem und realem Verhalten
(2009-03-03)So far, there have been few experimental studies concerning the similarities and differences of helping behavior and civil courage. In contrast to research on helping behavior, there is ... -
Charakterisierung von Mikrogliafunktionen im Simianen Immundefizienzvirus (SIV) - Rhesusaffentiermodell für AIDS
(2009-01-23)Nearly 60% of patients infected with HIV are affected by neurological and psychiatric symptoms. The motor and cognitive dysfunctions, as well as behavioral changes are described by the term ... -
Funktionelle Analyse von MHC-Klasse-I-Genen der Rhesusaffen (<i>Macaca mulatta</i>)
(2008-09-01)This thesis focuses on the structure and function of rhesus macaque (Macaca mulatta, Mamu) major histocompatibility complex (MHC) class I genes. As the cellular immune response is at least ... -
CaMKII-dependent regulation of ion channels and its role in cardiac arrhythmias
(2008-07-24)Intracellular calcium (Ca2+) is a central second messenger, which translates the electrical signal into cardiac contraction. This process is termed excitation-contraction coupling (E-C ... -
Functional analysis of IGFBP-2 overexpression in mouse liver myofibroblasts: Therapeutic implication for liver fibrogenesis
(2008-05-20)Liver fibrosis is characterized by abnormal accumulation of extracellular matrix (ECM) proteins which are secreted from the cells of the fibroblast lineage during chronic liver injury. Different liver cell populations ... -
Cell-penetrating peptide-enhanced delivery of heat shock proteins in models of neurodegeneration
(2008-04-30)The hallmark of Parkinson's disease (PD) is the loss of dopaminergic (DA) neurons in the substantia nigra (SN), the depletion of striatal dopamine levels, and the presence of intraneuronal proteinaceous cytoplasmatic ... -
Anti-Apoptosis and Regeneration in the Visual System: Effects of BAG1 (Bcl-2-associated athanogene-1)
(2008-04-28)In the present work, we investigated Bcl-2-associated athanogene-1 (BAG1) as a therapeutic molecule in the lesioned visual system in vivo. The effects of BAG1 were tested in two in vivo models of apoptosis and regeneration, ... -
Role of intestinal epithelium in inflammatory bowel disease: effect of cytokines and glucocorticoids on CXCL8 and CXCL10 gene expression and NF-kB signalling in intestinal epithelial cell lines
(2008-04-24)Activation of intestinal epithelial cells (IEC) may occur either by luminal antigens stimulation or by inflammatory signals deriving from immune cells in the close vicinity. Production of chemokines by the intestinal ... -
Untersuchung zur wechselseitigen Beeinflussung von Chemotaxinen und Dendritischen Zellen
(2008-04-01)Prostaglandin (PG) E2 and IL-4 have been implicated in maturation of DC and in the modulation of DC migration. In the present study, IL-4 as well as IL-13 were found to impair migration of murine DC and macrophages in ... -
Funktionelle Analysen deregulierter Signalwege transformierter B-Lymphozyten - Das Epstein-Barr-Virus-Onkogen LMP1
(2007-06-20)The development of different tumor entities can often be correlated with a viral infection. One of this tumor associated viruses is the Epstein-Barr virus (EBV). More than 90% of the human ... -
Regulation des mitochondrialen Zerfalls innerhalb der neuronalen Apoptose
(2007-05-23)Under physiological conditions, mitochondrial morphology dynamically shifts between a punctuate appearance and tubular networks by fission and fusion events. Mitochondrial apoptosis pathways ... -
Vergleich der Radikalreaktionen von Melatonin und strukturverwandten Indolaminen in unterschiedlichen Oxidationssystemen.
(2007-01-29)A comparison analysis in structure related Indolamine of Melatonin showed that small changes of Substituenten already draw considerable losses after themselves in oxidation chemistry. ... -
Konsequenzen der Expression des Ether à go-go Kaliumkanals
(2006-08-02)This work provides the first description of a highly effective and specific siRNA-based inhibitor for the potential oncogene hEAG1 (human ether à go-go channel), which proved to be ... -
Eskalierendes Commitment und präferenzkonsistente Informationsbewertung
(2006-07-14)The PhD thesis offers a new explanation for escalation of commitment. Escalation of commitment is the tendency to persist in losing courses of action or to throw good money after bad. ... -
BEHAVIOURAL AND PHARMACOLOGICAL VALIDATION OF CHRONIC SOCIAL STRESS AS A MODEL OF DEPRESSIVE-LIKE SYMPTOMS IN RATS
(2006-06-22)In order to develop a model of chronic social stress in rats, in the first study the male Wistar rats were subjected to five weeks daily exposure to social defeat. This protocol resulted ... -
Pharmakologische Untersuchungen zu endokrinen Effekten des UV-Filters Ethylhexyl-methoxycinnamat
(2006-05-31)During the last years it has become apparent that an increased exposure to UV-irradiation is accompanied by noxious side effects. Ethylhexyl-methoxycinnamate (OMC), a cinnamate derivative, ... -
Untersuchung endokriner Effekte von Benzophenon-2 und 17β-Estradiol in estrogen-rezeptiven Organen
(2006-05-31)Hormones control many essential functions of the human body. These messengers are involved in regulating growth, reproductive and metabolic functions, the water-electrolyte balance and the ... -
Neuroautonome Regulation und deren emotionale Modulation bei Mäusen
(2005-05-20)In this dissertation, characteristic somatomotor-, neuroautonomic- and endocrine responses of mice to external stimuli with innate or learned aversive attributes were investigated. Unconditioned ... -
Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
(2004-11-18)Hepatic stellate cells (HSCs) and liver myofibroblasts (LMFs) represent major cell populations involved in liver fibrogenesis. Several lines of evidence demonstrate that in contrast to LMFs, ...