Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Fritz, Hans-Joachim Prof. Dr."
Now showing items 1-20 of 36
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Charakterisierung des 5-HT<sub>3B</sub>-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus
(2012-01-24)5-HT3B is a subunit of the serotonin receptor type 3 (5-HT3), which is an ion channel of the cys-loop receptor family. The gene HTR3B encodes for 5-HT3B. The polymorphism ... -
Studies into the structural basis of the DNA uridine endonuclease activity of exonuclease III homolog Mth212
(2011-05-16)Mth212, an exonuclease III homolog from the archaeon Methanothermobacter thermoautotrophicus, compensates the lack of a DNA uracil glycosylase (UDG) in this organism by catalyzing direct ... -
Use of peptide microarrays for mapping viral b cell epitopes
(2011-03-17)Mapping targets of antibodies - in particular neutralizing ones - is of great value for monitoring vaccination efficacy as well as for development of novel vaccines and reagents for ... -
Charakterisierung der angeborenen Immunantwort in SIV-infizierten Rhesusaffen
(2010-01-28)Members of the APOBEC protein family of deaminases like A3G and A3F are components of the innate immunity capable to inhibit the replication of HIV in vitro. Their ability to influence viral ... -
Charakterisierung mukosaler Immunantworten im SIV-Makaken-Modell für AIDS
(2010-01-07)The massive damage of mucosal tissue as a consequence of infection as well as the sexual transmission of HIV via mucosa-associated tissue requires a better knowledge about these organs. The comparative flow-cytometric ... -
Aktivität endogener Retroviren in Tumorgeweben von Primaten
(2009-09-14)The human endogenous retroviruses of the family K (HERV-K) is an evolutionary young group of retroviral sequences. In comparison with other endogenous retroviruses, some HERV-K proviruses ... -
Identifikation und funktionelle Charakterisierung von Effektorproteinen des Typ III Sekretionssystems von Chlamydophila pneumoniae
(2009-09-08)Chlamydophila pneumoniae causes atypical pneumoniae and is also discussed as a risk factor for a wide range of chronic diseases like chronic obstructive pulmonary disease or atherosklerosis. ... -
Analysen zu TRIM-Genen in Primaten
(2009-04-16)In this work, the evolution of TRIM genes with identical domain structure as the antiviral TRIM5a was studied. The analysed TRIM genes form two clusters on chromosome 6 and 11 (MHC and 11p15 ... -
Rezeptor-vermittelte Lieferung von Genen durch gezielte Liposomen und Quantum Dots
(2009-01-16)The design of liposomal carriers for gene or drug delivery is an active field in current biomedical research. An important issue is the targetin of the c ach i -
Identification and Functional Characterization of unc5A during Neocortical Regionalization
(2008-04-15)During the evolution of mammalian species, the cerebral neocortex acquired improved sensory, learning, and decision-making activities in parallel to its structural regionalization for specific functions. Each of these ... -
Charakterisierung zellulärer Immunantworten von mit SIV immunisierten und infizierten Makaken
(2007-11-26)The infection with HIV and the resulting AIDS-disease are a global challenge for mankind. The infection of macaques with simian immunodeficiency virus (SIV) is the most important animal ... -
Determination of the Structure of the Spliceosomal U6 snRNP from Yeast, <i>Saccharomyces cerevisiae</i>
(2007-08-09)The U6 small nuclear RNA (snRNA) undergoes major conformational changes during the assembly of the spliceosome and catalysis of splicing. It associates with the specific protein Prp24p, ... -
Übertragung von BSE auf nicht humane Primaten als Modell für die variante Creutzfeldt-Jakob Erkrankung (vCJD) im Menschen
(2007-06-05)The EU-study QLK1-CT-2002-01096 was designed to assess the risk of vCJD (variant Creutzfeldt-Jakob disease) infection in humans via BSE-contaminated food in an animal model. Groups of six ... -
Isolation and Characterization of Human Precatalytic Spliceosomal B Complexes
(2007-04-26)The spliceosomal B complex is the substrate that undergoes catalytic activation leading to catalysis of pre-mRNA splicing. Previous characterization of this complex was performed in the ... -
Einfluss der Helix 1 und des β-Faltblattes auf die Aggregation des Prionproteins und seine Amyloidstruktur
(2007-02-07)Prion diseases are caused by the aggregation of the native α-helical prion protein PrPC into its pathological β-sheet-rich isoform PrPSc. In current models of PrPSc, helix1 is assumed to ... -
Efficacy of enzyme replacement therapy in α-manosidosis mice
(2006-08-11)The Lysosomal Storage Disorders (LSD) are a group of about 50 diseases caused by genetic defects that affect one or more of the lysosomal hydrolases. The defect results in the accumulation ... -
Molecular Characterization of pFGE, the Paralog of the C-α-Formylglycine-generating Enzyme
(2006-03-01)C-α formylglycine (FGly) is the catalytic residue in the active site of sulfatases. In eukaryotes, it is generated in the endoplasmic reticulum by post-translational modification of a ... -
Analysis of two kinetically distinct components of transmitter release at a fast synapse of the mammalian central nervous system
(2006-01-06)Two kinetically distinct components of transmitter release have been observed in Ca2+ uncaging experiments at a CNS synapse in rats, and both release components showed a steep dependence ... -
Protein dynamics in the nucleus: Implications for gene expression
(2005-11-08)Fluorescence recovery after photobleaching (FRAP) microscopy was used to determine the kinetic properties of Polycomb group proteins in whole living Drosophila organisms (embryos) and ...