Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Hardeland, Rüdiger Prof. Dr."
Now showing items 1-20 of 74
-
Die Übernutzung nicht valider Ratschläge: Warum schlechte Ratschläge über Gebühr berücksichtigt werden
(2011-01-06)Advice utilization during judgment and decision-making is an integral part of everyday life. The most stable finding in the literature on advice taking is that judges tend to place too much ... -
Charakterisierung der Proteinphosphatase 1E (PPM1E) - Lokalisierung und Trunkation in Gehirngewebe und Effekte auf neuronale Morphologie in primärer Neuronenkultur
(2010-11-26)Alzheimer s disease (AD) is a progressive neurodegenerative disorder, characterized by early deficits in learning and memory with eventual loss of higher cognitive functions. Although ... -
Genetische Variabilität in der phagozytären NAD(P)H-Oxidase: Funktionelle Charakterisierung und Bedeutung für die Zytostatika-Therapie
(2010-01-05)Cardiotoxicity is a severe side effect of doxorubicin-containing chemotherapy as used in the treatment of several tumors and leukemia and up to 6% of treated patients develop congestive ... -
Identifikation von Zielen und molekulare Charakterisierung des RNA-Bindeproteins XSeb4R in Xenopus laevis
(2009-10-28)While developmental processes have been extensively studied in the context of transcriptional regulation, much less is known about regulation via translational regulation. RNA-binding ... -
Proteomanalyse lysosomaler Membranen: Identifizierung und Charakterisierung neuer lysosomaler Membranproteine
(2009-06-18)Lysosomes are intracellullar acidic vesicles, which contain a variety of soluble and membrane-bound proteins like hydrolases and transport-systems. They are found in all nucleated ... -
Impact of iron-deficiency upon behaviour and protein expression in the male mouse with implications for Restless Legs Syndrome
(2009-06-12)Restless legs syndrome (RLS) comprises of both sensory and motor symptoms, observed as an increased pain and periodic jerking movement of the legs. There are two forms of RLS; one ... -
Rezeptor-vermittelte Lieferung von Genen durch gezielte Liposomen und Quantum Dots
(2009-01-16)The design of liposomal carriers for gene or drug delivery is an active field in current biomedical research. An important issue is the targetin of the c ach i -
Possible Influences of Circadian Melatonin on the Function of Neurosecretory Neurons and Serotonin-Modulated Behavior on Crayfish.
(2009-01-15)Crustaceans have frequently been used to study the neuroethology of diverse function as agonistic behavior and circadian rhythms. Whether the highly stereotyped and quantifiable agonistic ... -
Regulation of rat Liver Glucokinase Gene Expression by Sterol Regulatory Element Binding Protein-1a and Forkhead box classO1 Transcription factors
(2008-10-13)Glucokinase (GK) also known as hexokinase IV catalyzes phosphorylation of glucose to glucose-6-phosphate. In contrast to other hexokinases, GK has a low affinity for glucose, is not ... -
Untersuchungen zur antiangiogenen Aktivität des matrizellulären Proteins Thrombospondin-2
(2008-07-21)The formation of new tumor vessels (tumorangiogenesis) is an important mechanism for the growth and progression of tumors. Tumorangiogenesis depends on a complex interplay between pro-and ... -
Differentielle Expression und Funktion eines glialen Kaliumkanals (K<sub>ir</sub>4.1, KCNJ10) im Rückenmark und Bedeutung in einem neurodegenerativen Krankheitsmodell
(2008-07-10)In the last decade it became more and more obvious, that inwardly-rectifying potassium channels (Kir), beside their classical role in establishing and maintaining the resting membrane ... -
Expressionsanalyse des humanen Histonsubtyps H1x
(2008-06-02)Nuclear eukaryotic DNA is organised as chromatin in conjunction with proteins. The basal structural organisation unit of chromatin is the nucleosome consisting of the nucleosome core particle, ... -
Functional analysis of IGFBP-2 overexpression in mouse liver myofibroblasts: Therapeutic implication for liver fibrogenesis
(2008-05-20)Liver fibrosis is characterized by abnormal accumulation of extracellular matrix (ECM) proteins which are secreted from the cells of the fibroblast lineage during chronic liver injury. Different liver cell populations ... -
Untersuchung Rezeptor-vermittelter Interaktionen zwischen Defensinen und Zellen des Immunsystems
(2008-05-02)Human defensins are natural peptide antibiotics. On the basis of the position and bonding of their six highly conserved cysteine residues, they are divided into two families, designated alpha- und beta-defensins. ... -
Role of intestinal epithelium in inflammatory bowel disease: effect of cytokines and glucocorticoids on CXCL8 and CXCL10 gene expression and NF-kB signalling in intestinal epithelial cell lines
(2008-04-24)Activation of intestinal epithelial cells (IEC) may occur either by luminal antigens stimulation or by inflammatory signals deriving from immune cells in the close vicinity. Production of chemokines by the intestinal ... -
Downstream targets of transcription factor Pax6 in cortical development
(2008-04-22)Pax6 is a transcription factor with key functional roles in patterning and arealization of the cortex. We studied regulation of gene expression in Pax6 mutants through microarray analysis. This allowed us to focus on ... -
Untersuchung zur wechselseitigen Beeinflussung von Chemotaxinen und Dendritischen Zellen
(2008-04-01)Prostaglandin (PG) E2 and IL-4 have been implicated in maturation of DC and in the modulation of DC migration. In the present study, IL-4 as well as IL-13 were found to impair migration of murine DC and macrophages in ... -
Induktion von Apoptose in gynäkologischen Karzinomen <i>in vitro</i> und <i>in vivo</i> durch Antagonisten des Gonadotropin-Releasing Hormons Typ II
(2008-02-22)In human endometrial, ovarian and breast cancers, GnRH-I and GnRH-II and their receptors are parts of a negative autocrine regulatory system of cell proliferation. Based on a tumour-specific signal transduction, GnRH-I ... -
Vergleich der Genexpression im entzündlichen Kolonepithel und im kolorektalen Karzinom im Hinblick auf das erhöhte Tumorrisiko bei chronisch entzündlichen Darmerkrankungen
(2008-02-04)In this thesis, the alterations are investigated that are responsible for an increased tumour risk in colonic epithelium of humans with inflammatory bowel disease (IBD). To detect early ... -
MHC-Klasse-I-Gene von Weißbüschelaffen (Callithrix jacchus) und deren Expression im Gehirn
(2008-01-17)MHC class I genes and their products are essential components of the adaptive immune response. According to numerous studies it was assumed that neurons do not express MHC class I genes ...