Dokumente GZMB - Göttinger Zentrum für molekulare Biowissenschaften nach Titel
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Investigation of cpeb1 transcript regulation and potential functions of CPEB1 in germline development in X. laevis
(2017-11-17)Germline specification represents the first functional segregation between two cell populations in the embryo. The germ cell lineage is the source of genetic variation and is essential for the continuity of the species. ... -
Investigation of Protein Structure and Dynamics
(2009-07-22)This thesis addresses three aspects of protein function:Part I describes the structural investigation of a calmodulin-peptide complex by NMR spectroscopy. The intracellular calcium sensor ... -
Metabolic and developmental functions of the transcription factor Gcn4p of Saccharomyces cerevisiae
(2011-10-17)The bakers’ yeast Saccharomyces cerevisiae executes two well established pathways, the ‘General Amino Acid Control’ (GAAC) and the ‘Unfolded Protein Response’ (UPR), which are in contrast to mammals not essential but ... -
Metabolism of NHP and SA
(2023-01-02)When mobile organisms face a threat, they have the options of a fight or flight as reaction. The sessile nature of plants narrows their response option down to defend themselves against the threat. Therefore, plants developed ... -
Mikroautophagischer Abbau von Teilen der Kernhülle und Untersuchungen zum Transport und der Aktivität von Atg15p in der Hefe Saccharomyces <i>cerevisiae</i>
(2008-08-12)Autophagy is a ubiquitous process, occurring in all eukaryotic cells. Microautophagy sequesters cytoplasm or organelles by invagination or septation of the vacuolar membrane. In Saccharomyces ... -
Molecular architecture of SF3B and the structural basis of splicing modulation
(2019-06-20)During splicing non-coding introns are excised from the transcribed pre-messenger RNA (pre-mRNA), and the protein-coding exons are ligated to generate the mature mRNA. In cells, the pre-mRNA splicing reaction is catalyzed ... -
Ein neu entdeckter Weg der Reparatur hydrolytisch geschädigter DNA-Cytosinreste, etabliert im thermophilen Archaeon Methanothermobacter thermautotrophicus ΔH
(2007-11-21)The DNA bases cytosine, adenine and guanine can be deaminated at the exocyclic aminogroups by spontaneous hydrolysis. Cytosine deamination leads to the RNA base uracil and is of particular mutagenic relevance, because ... -
Participation of Eag1 in tumor relevant pathways
(2010-01-12)Ether--go-go-1 (Eag1) is a CNS-localized voltage-gated potassium channel that is found ectopically expressed in a majority of extra-cranial solid tu- mors. While evidence linking Eag1 to tumor biology has been well ... -
Patched-assoziierte Tumoren: Modifikatorgene und Pathogenese
(2008-06-05)Patched (Ptch), a component of the Hedgehog (Hh)/Ptch signalling cascade, is frequently mutated in basal cell carcinoma (BCC), medulloblastoma (MB) and rhabdomyosarcoma (RMS). Ptchneo67/+ mice, in which exons 6 and 7 are ... -
Prevention and treatment: Effects on pathological alterations in transgenic Alzheimer’s disease mouse models
(2021-06-21)Alzheimer’s disease (AD) is a neurodegenerative disorder representing the most common form of dementia worldwide. To date, no successful therapeutic approach to treat AD has been developed, hence preventive strategies ... -
Proteome-wide Identification of New Molecular Targets Affected by Methotrexate in Acute Promyelocytic Leukaemia Cell Line
(2007-06-11)Methotrexate (MTX) was first introduced as a cytotoxic agent that inhibits nucleotide biosynthesis in various cancer disorders. Accumulating evidences suggest that MTX inhibits the proliferation of malignant cells by ... -
The rhizosphere effects of <i>Fagus sylvatica</i> L. and <i>Fraxinus excelsior</i> L. saplings on greenhouse gas fluxes between soil and atmosphere
(2012-12-07)Tree species influence the soil through stemflow and throughfall water, leaf litter and the root system. Little is known about the effects of tree roots on the C and N dynamics of the soil and the gas exchange with ...
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The role of Lissencephaly-1 protein in male germ cell differentiation
(2009-07-24)In the present study the function of Lissencephaly-1 protein in male germ cell differentiation was analysed. A gene trap mouse model (L39) in which a gene trap vector had integrated in intron 2 of Lis1 gene resulted in ... -
The Role of the HECT-Type Ubiquitin Ligases WWP1 and WWP2 in Nerve Cell Development and Function
(2012-03-15)Posttranscriptional modification of proteins through the ubiquitin pathway has recently emerged as an essential regulatory mechanism controlling neuronal development and function. WW domain-containing protein-1 and -2 ... -
The signal transduction of synapse formation and it's failure in Rett syndrome
(2017-04-26)The mechanistic target of rapamycin (mTOR) perceives and integrates various extracellular and intracellular signals and regulates cellular growth and homeostasis. The evolutionary conserved serine/threonine kinase can form ... -
Transcriptional control in the context of primary neurogenesis
(2006-09-18)The Myc/Max/Mad network of bHLH-Zip transcription factors plays an essential role in a variety of cellular processes including proliferation, differentiation and apoptosis. Mxi1, a Mad family member, was previously ... -
Untersuchungen zur Funktion der Gene MPH1 und MMS2 aus Saccharomyces cerevisiae bei der fehlerfreien Umgehung von replikationsarretierenden DNA-Schäden
(2010-02-25)in vivo error free bypass of replication blocking lesions is done by at least two distinct processes: homologous recombination via sister chromatid interaction (SCI) and post replicative repair (PRR). Additionally PRR is ... -
Untersuchungen zur Wirksamkeit von Dacarbazin und Temozolomid bei der Behandlung des kutanen Melanoms in Assoziation mit DNA-Reparatur
(2010-02-09)The aim of this study was to identify individual host markers for hematologic side effects and treatment efficacy of dacarbazine or temozolomide in melanoma treatment. Such markers could facilitate the decision for or ...