Medizin: Recent submissions
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Häufigkeit der intra- und frühen postoperativen Blutungskomplikationen bei Netzhautoperationen in Abhängigkeit von gerinnungshemmenden Substanzen
(2024-04-26)In numerous fields of operative medicine, high-quality studies and guidelines are available for the perioperative management of hemostasis-modulating agents. However, in vitreoretinal surgery, meaningful recommendations ... -
Prospektive, randomisierte Bewertung des Einsatzes einer stützenden Herrenunterhose nach skrotalen Eingriffen hinsichtlich besserer postoperativer Ergebnisse und gesundheitsbezogener Lebensqualität
(2024-04-26)Background: Elective scrotal surgery is associated with a high rate of postoperative complications. There is no specific recommendation for postoperative care. Aim: We investigated whether support underwear has an impact ... -
Dendritisches Polyglycerolsulfat als neues Therapeutikum der akuten GvHD
(2024-04-26)Despite decades of research, acute GvHD (aGvHD) remains to be one of the leading causes of increased mortality and morbidity for patients following stem cell transplantation. Due to the limited therapeutic options for the ... -
Fluoreszenz-in-situ-Hybridisierung und funktionelle Analyse der KMT2A-MAML2 Translokation in epithelialen Thymusneoplasien und den humanen Zelllinien 1889c und MP-57
(2024-04-25)Thymoma and thymic carcinoma are very rare epithelial neoplasms of the thymus. Little is known about the pathogenesis of these tumors. Targeted therapeutic approaches have hardly been established to date, and the recurrence ... -
Characterization of urine proteome pattern changes associated with early diabetic nephropathy: a proteomic approach
(2024-04-19)Type 2 diabetes mellitus has become the most common cause of kidney failure in Europe and the United States. In Germany, 8.7 million people live with type 2 diabetes, although an estimated two million more affected people ... -
Target recognition of an RNA methyltransferase
(2024-04-18)To date more than 150 different RNA modifications have been detected in cellular RNAs and are collectively termed the epitranscriptome. RNA modifications occur at different positions within each of the four bases or the ... -
Die Entwicklung von Nanobody-funktionalisierten Goldoberflächen
(2024-04-15)Atomic force microscopy enables three-dimensional imaging of samples. The use of antibodies to improve the accuracy of microscopy is an established method. An antibody can be linked to the golden tip of an atomic force ... -
Complementary medicine treatment options for children with diffuse intrinsic pontine gliomas
(2024-04-11)Diffuse intrinsic pontine glioma is a rare but lethal brain tumor with a median survival of eleven months after diagnosis. There has been no significant improvement in survival over the past 50 and more years despite ... -
Characterization Of Pirfenidone Effects In Human Cardiac Fibroblasts
(2024-04-08)Background Cardiac fibrosis is a major problem in heart diseases, but it is still lacking an effective therapy. The drug pirfenidone has shown several anti-fibrotic effects in animal models of heart diseases and is already ... -
Analyse der ARHGAP29-abhängigen Signalisierung der Invasion von Mammakarzinomzellen
(2024-04-08)Despite expanded early detection examinations and improved treatment options, breast cancer remains the most common cause of death from cancer in women worldwide. Fundamental to the development of innovative therapies is ... -
Extending the classical histological routine through microcomputed tomography imaging and multimodal image processing
(2024-04-08)Histological analysis has proven to be the de facto gold standard for the characterization of hard and soft tissue samples at cellular resolution in both clinical routine and biomedical research. After the tissue sample ... -
Activity-dependent turnover of the Perineural Extracellular Matrix
(2024-04-05)The different molecules present in the extracellular space of the brain make-up the perineural extracellular matrix (ECM). One of the specializations of the perineural ECM, the perineural nets (PNNs), are lattice-like ... -
Die biomechanische Analyse des Kiefergelenks mit Hilfe eines neuen Echtzeit-MRT-Verfahrens
(2024-04-03)Aim: The traditional hinge axis theory of temporomandibular joint (TMJ) dynamics is increasingly being replaced by the theory of instantaneous centers of rotation (ICR). Typically, ICR determinations are based on theoretical ... -
Elimination des freien Hämoglobins an der Herz-Lungen-Maschine zur Prävention eines akuten Nierenversagens nach kardiochirurgischen Eingriffen
(2024-04-02)Acute kidney failure after cardiac surgery using the heart-lung machine (HLM) remains a serious complication with high morbidity and mortality. There are currently no valid preventive concepts that enable perioperative ... -
Prospektive Untersuchung des Schädelwachstums Frühgeborener von Geburt bis zum errechneten Geburtstermin
(2024-03-28)Using stereophotogrammetry for a longitudinal 3D analysis of the head growth of preterm born neonates from birth to term. -
Evaluation des therapeutischen Potentials von intravenös appliziertem Metallothionein-II im Schlaganfall Modell der Maus unter Thrombolyse
(2024-03-27)Stroke is the second leading cause of death worldwide. The only available drug therapy is thrombolysis using recombinant tissue-specific plasminogen activator (rtPA), which can only be used to a limited extent due to the ... -
Der Einfluss von Aβ4-42 auf die Kognition und die Anwendung von Suchstrategien im Morris Water Maze im Tg4-42-Mausmodell
(2024-03-25)The relevance of Alzheimer's dementia for our society is increasing. Soluble amyloid beta (Aβ) plays a particularly important role in the genesis of this disease. Aβ4-42 in particular, which is truncated before the fourth ... -
Rolle des G-Protein-gekoppelten Östrogenrezeptors 1 (GPER1) beim Zervixkarzinom
(2024-03-21)Cervical cancer is the fourth most common cancer in women and after the mamma carcinoma the second most common gynecological carcinoma. The G-Protein-coupled Estrogen Receptor 1 (GPER1) is an important ubiquitous receptor ... -
Epigenetische Grundlagen der (Kreuz)-Resistenz von Antiandrogenen neuer und neuster Generation
(2024-03-20)Prostate cancer grows androgene-dependent, because of which, antiandrogen therapy is used in advanced tumor stages. Most antiandrogens inhibit the androgen receptor directly, but Abiraterone inhibits androgen synthesis. ... -
Die prognostische Bedeutung von Vorhofflimmern bei Patienten mit akuter Lungenembolie
(2024-03-18)Background: Although prior studies indicate a high prevalence of atrial fibrillation (AF) in patients with pulmonary embolism (PE), the exact prevalence and prognostic impact are unknown. Methods: We aimed to investigate ...