Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Titel
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Development of a biotechnologically enhanced sterile insect technique to fight coleopteran pests
(2021-06-30)Tribolium castaneum commonly referred to as the Red Flour Beetle (RFB) belongs to the class Insecta and order Coleoptera, and it’s the best model organism for coleopterans. About 380,000 coleopteran species, constituting ... -
Development of an orthogonal ligand-receptor pair based on synthetic estrogen analogs and engineered estrogen receptor for transcriptional regulation
(2007-05-29)The aim of this dissertation was the development of an inducible gene switch based on a modified human estrogen receptor and non-steroidal estradiol analogs. To that end, an in vivo test ... -
Development of Transgenic Sterile Insect Technique Strains for the Invasive Fruit Pest Drosophila suzukii
(2020-12-03)Globalization has contributed enormously to emergence and expansion of invasive pests. A recent example is the invasion in Europe and the USA by the cherry vinegar fly Drosophila suzukii. The pest has high potential to ... -
Development of Viral Tools for CNS Gene Transfer: Adeno-Associated Viral Vectors in Gene Therapy of Parkinson's Disease
(2006-08-09)Gene transfer to the brain is a promising therapeutic strategy for a variety of neurodegenerative disorders including Parkinson s disease (PD). PD is characterized by a progressive degeneration of the nigrostriatal ... -
Developmental regulators and secreted effector molecules of the fungal pathogen Verticillium spp.
(2020-09-29)The haploid Verticillium dahliae and the allodiploid V. longisporum are two filamentous fungal pathogens, which colonize the plant vascular system of a broad host range including important crops. They survive outside of ... -
Different inter-domain linker regions regulate the binding of UHRF1 and NP95 to histone H3
(2017-06-15)Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1 in human, NP95 in mouse) is an important epigenetic regulator connected to apoptosis and tumor development. UHRF1/NP95 integrates different chromatin modifications ... -
DIFFERENTIAL GENE EXPRESSION DURING ISCHEMIA AND REPERFUSION IN AN EXTRACORPOREAL SMALL BOWEL PERFUSION MODEL IN SWINE
(2002-12-04)In a perfusion model using isolated small intestine of the pig, a strong inflammatory reaction with cytokine release and induction of corresponding mRNA expression was shown during reperfusion ... -
Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines
(2013-06-07)Background: Worldwide, colorectal cancer is the third most common malignancy. The development of the colorectal cancer (CRC) is a multistep process that involves e.g. an accumulation of mutations in tumor-growth promoting ... -
Differentiation of Flk-1 positive multipotent adult germline stem cells into endothelial cells in vitro and in vivo
(2011-03-08)Multipotent adult germline stem cells (maGSCs) offer a novel route to cell-based therapy without immune rejection and ethical limitations. The present study showed the generation and expansion ... -
Differentielle Expression und Funktion eines glialen Kaliumkanals (K<sub>ir</sub>4.1, KCNJ10) im Rückenmark und Bedeutung in einem neurodegenerativen Krankheitsmodell
(2008-07-10)In the last decade it became more and more obvious, that inwardly-rectifying potassium channels (Kir), beside their classical role in establishing and maintaining the resting membrane ... -
Differentielle Genexpressionsanalyse aktivierter Endothelzellen
(2001-08-28)Differential Display-PCR (DD) is a mRNA-fingerprint technique to identify differentially expressed genes by comparing displayed sets of randomized amplified cDNA. For this, an elaborated ... -
Diplopoden auf extensiv bewirtschafteten Ackerflächen
(2008-02-08)The population of millipedes (diplopods) and their impact on the decompositon of oilseed rape was investigated during the years 1990 1998 on different agricultural fields in the Leine ... -
Directed evolution of novel properties starting from HisF of <i>Thermotoga maritima</i> as a structural scaffold
(2006-01-24)tHisF, imidazole glycerol phosphate synthase from hyperthermophilic organism T. maritima, with a (ba)8-barrel structure was used as scaffold for directed evolution of enzymes. The ... -
Discovery and Functional Characterization of Novel Soil-metagenome Derived Phosphatases
(2019-07-22)Phosphatases, including phytases, play a major role in phosphorous cycle, cell metabolism, biotechnology, and pathogenic processes. Despite their relevance as biocatalysts, the study of phosphatases/phytases has been almost ... -
Dissecting synaptic mechanisms of sound encoding in the mouse cochlea
(2019-05-23)Cochlear inner hair cells (IHCs) are the genuine sensory receptors that translate sound-borne cochlear vibrations into neuronal signals via ribbon synapses with the spiral ganglion neurons (SGNs). The precise mechanisms ... -
Dissecting the ß-catenin-dependent and -independent functions of BCL9 and BCL9-2 in intestinal tumorigenesis
(2013-04-26)The Wnt/ß-catenin signaling pathway is highly conserved and plays an important role during embryonic development, in adult homeostasis and tumorigenesis. The members of the novel BCL9 family were characterized as co-activators ... -
Dissociating Inherent Emotional and Associated Motivational Salience in Human Face Processing
(2018-05-30)The human brain is challenged to select only the most relevant stimuli, assured by salienceand goal-driven attention mechanisms. As not only stimuli carrying inherent salience (e.g., facial expressions of emotion), but ... -
Distinct roles of PI4P 5-kinase isoforms in polar tip growth of pollen tubes
(2009-08-18)Phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) occurs in the tip-plasma membrane of growing pollen tubes. Because enzymes responsible for PI(4,5)P2-production at that location are ... -
Distribution and ecological characteristics of members of the Roseobacter group
(2020-08-27)Marine Rhodobacteraceae are collectively referred to as the Roseobacter group, and due to their functional versatility and high abundance in diverse marine habitats, serve as model organisms in the study of microbial ... -
Diversität und Biogeographie der Farne und Vögel Boliviens: Niche Modellierung GIS Applicationen
(2010-06-02)This dissertation focuses on a wide range of biogeographic and macroecological aspects of bird and fern species from Bolivia. In the first chapter I outlined the general purpose of this ...