Browsing Human- und Zahnmedizin by Issue Date
Now showing items 1-20 of 3061
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Optogenetic characterization of targeting-optimized Chronos and f-Chrimson variants for auditory encoding in mice
(2024-12-03)Electrical cochlear implants bypass the physiological micromechanics and synaptic sound encoding by sensory hair cells in the cochlea and provide state-of-the-art treatment of sensorineural hearing loss. To overcome the ... -
Role of FOXM1, GPX1, and CCNB1 in cisplatin resistance in malignant thymomas and thymic carcinomas
(2024-12-02)Cisplatin resistance in malignant thymomas and thymic carcinomas remains a significant challenge, impairing therapeutic efficacy and patient outcomes. This study investigates the roles of Glutathione Peroxidase 1 (GPX1), ... -
Die Beteiligung der Transmembranproteine EMMPRIN und Connexin 43 an der Epithelial-Mesenchymalen Transition (EMT) und Metastasierung im oralen Plattenepithelkarzinom
(2024-12-02)Metastasis is a major challenge in the progression of oral squamous cell carcinoma (OSCC) and is closely related to epithelial-mesenchymal transition (EMT) of tumor cells. In the present study, the expression profiles of ... -
Genetische Polymorphismen im Bereich der Interferon Lambda (IFNL)-Gene und deren prädiktiver Wert für ein Ansprechen auf eine Chemo- oder Radiotherapie bei onkologischen Patienten
(2024-11-29)Chemotherapy and radiotherapy are among the pillars of conventional cancer treatment. The toxic effects of chemotherapeutic agents and the ionizing effects of radiotherapy induce necrosis in neoplastic cells, leading to ... -
Entwicklung eines zellbasierten Nachweisverfahrens für Serum-anti-Myelin-Oligodendrozyten-Glykoprotein-Antikörper
(2024-11-29)Myelin oligodendrocyte glycoprotein (MOG) is a protein of the outermost layer of the myelin sheath that plays an important role in the pathogenesis of idiopathic demyelinating diseases. The detection of anti-MOG-specific ... -
Zur Rolle von EZH2 in neuroendokrinen Neoplasien
(2024-11-29)Neuroendocrine neoplasms are rare neoplasms with an increasing incidence, primarily occurring in the gastroenteropancreatic region and the lungs. They are classified into the prognostically more favorable NET and the less ... -
Fragebogen zur Evaluation der Körperkonstitution im Rahmen der japanischen Kampo-Medizin
(2024-11-29)Introduction: In traditional Japanese Kampo medicine, a profound anamnesis is completed by clinical examination. The resulting clinical image forms the basis of the patient’s diagnosis pattern, including the recent mental, ... -
Shear Stress and NETosis
(2024-11-29)Neutrophil granulocytes, the most abundant type of circulating immune cells, engage in a process called NETosis when encountering certain pathogens and danger signals or experimentally induced by phorbol-12-myristate-13-acetate ... -
Biologische Eigenschaften von circRNA_015350/006696 in Neuronen und Astrozyten unter hypoxischen Bedingungen
(2024-11-29)CircRNAs are a group of non-coding RNAs that have only recently been discovered. Many of the biological functions of circRNAs are not yet fully understood. It is currently assumed that circRNAs can act as miRNA sponges, ... -
Rnaset2-Defizienz: Eine klinisch-experimentelle Betrachtung im Kontext der Typ-1-Interferonopathien
(2024-11-28)Rnaset2-deficient cystic leukoencephalopathy is a rare congenital disorder caused by a biallelic loss-of-function mutation. This dissertation consists of a clinical and an experimental part on this disease. Clinically, ... -
Evaluation der sonographisch bestimmten Gallenblasenwanddicke als nicht-invasiver Marker für das Vorliegen eines Leberparenchymumbaus
(2024-11-28)Liver cirrhosis is the final stage of various chronic liver diseases. Causes include chronic alcohol consumption, untreated chronic viral or autoimmune hepatitis, metabolic disorders, and medication, alongside cases with ... -
Impact of the sphingosine-1-phosphate receptor modulator siponimod on functional phenotypes of microglia
(2024-11-26)Over the last decades the number of drugs for the therapy of relapsing remitting multiple sclerosis (RRMS) increased significantly, whereas various approaches to develop an efficient therapy for secondary progressive ... -
Vergleichende materialabhängige Evaluation der marginalen und internen Passgenauigkeit bei der Chairside- und Labside-CAD/CAM-Fertigung von vollkeramischen Einzelkronen mittels zweier Analyseverfahren
(2024-11-22)Purpose: The aim of this study was to evaluate the material-dependent fit of CAD/CAM-fabricated all-ceramic restorations, focusing on the marginal and internal fit of monolithic single-tooth crowns produced using chairside ... -
Interaktion von Lymphomzellen und Makrophagen in einem in-ovo-Modell
(2024-11-21)In recent years, there has been increasing evidence that the tumor microenvironment plays a varying but important role in the development of lymphomas in different types of lymphoma and influences the success of treatment. ... -
Prospektive klinische Studie zur Bewährung metallkeramischer Kronen und vollkeramischer Zirkonoxidkronen nach einem Beobachtungszeitraum von 10 Jahren
(2024-11-19)This practice based prospective clinical study investigated the clinical performance of veneered all-ceramic crowns (VKK) with an anatomically shaped framework design and a ceramic veneer with long-term cooldown compared ... -
FOXO3 in myogener Differenzierung vor dem Hintergrund von Sarkopenie und Kachexie
(2024-11-19)Sarcopenia and cachexia are medical conditions that are characterized to different extent by a loss in muscle strength and muscle mass and cause a serious negative impact on patient`s health and quality of life. Until now ... -
Morphologische Studien zu Veränderungen der Vaskularisation der Cochlea bei verschiedenen Formen der Schallempfindungsschwerhörigkeit
(2024-11-19)The objective of this work was the further development and implementation of methods for the qualitative and quantitative investigation of the fine-vascular structures of the lateral wall of the murine cochlea in presbycusis ... -
A single center long-term comparison of remote magnetic navigation-assisted catheter ablation versus manual catheter ablation of atrial fibrillation
(2024-11-19)Background: Data comparing remote magnetic catheter navigation (RMN) with manual catheter navigation (MCN) ablation of atrial fibrillation (AF) is lacking. The aim of the present study was to compare the outcome of RMN ... -
Die Assoziation zwischen niedrigem Blutdruck und der Aufmerksamkeitsdefizit-Hyperaktivitätsstörung (ADHS) im Verlauf von Kindheit und Adoleszenz.
(2024-11-18)Attention deficit hyperactivity disorder (ADHD) is one of the most common behavioral disorders in childhood and adolescence, associated with significant psychosocial impairment. The basic pathophysiology of ADHD may be ... -
Die Auswirkungen von Ostarine und Raloxifen auf die Skelettmuskulatur im ovarektomierten Rattenmodell
(2024-11-18)Due to demographic change, age-related diseases such as sarcopenia and osteoporosis are becoming an increasing challenge in Germany. One of the main causes of sarcopenia and muscle weakness is low sex hormone concentrations ...