Dokumente Human- und Zahnmedizin nach Erscheinungsdatum
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Assessment and Advancement of Genotype Imputation for genome-wide Association Studies
(2025-05-20)In genome-wide association studies (GWASs), genetic markers are independently tested across the whole genome to find genetic variants associated with a phenotype for a given population. The most commonly used markers for ... -
Verlauf der Knochendichte und der Knochenumbaumarker unter der Therapie mit Romosozumab
(2025-05-20)As a result of demographic changes and the associated increase in life expectancy, pharmacological treatment of osteoporosis will continue to gain importance in the coming years. Currently, the monoclonal antibody romosozumab ... -
Proteomische Analyse von nicht-kleinzelligen Lungenkarzinomen
(2025-05-19)Non-small cell lung cancer is a very common disease worldwide with a poor prognosis. Lung cancer is responsible for approximately 1.6 million deaths worldwide each year. A paradigm shift in the treatment of affected patients ... -
Untersuchung von Translationalem Readthrough bei Peroxisomalen Biogenesestörungen im Zellmodell
(2025-05-19)Premature termination codon (PTC) mutations account for approximately 10% of pathogenic variants in monogenic diseases. Stimulation of translational readthrough, also known as stop codon suppression, using translational ... -
Etablierung eines Zellkulturmodells zur Erforschung zyklischer Druckschwankungen an retinalen Ganglienzellen
(2025-05-19)Glaucoma, one of the most common causes of irreversible vision loss, leads to the progressive degeneration of retinal ganglion cells (RGCs), with elevated intraocular pressure being the only modifiable risk factor. However, ... -
Einfluss der differenzierten Präsentation multipler Wachstumsfaktoren in biomimetischen Multilayerbeschichtungen von Titanimplantaten auf die Angiogenese und Osteogenese
(2025-05-16)The aim of the present study was to test the simultaneous and sequential release of the growth factors rhVEGF165 and rhBMP2 from poly-L-lysine-heparin (PLL-Hep) and poly-L-lysine-heparin-collagen (PLL-Hep-Col) poly-electrolyte ... -
Einfluss von Citalopram auf die Alzheimer-Pathologie im Tg4-42-Mausmodell
(2025-05-12)Alzheimer’s disease is the most common form of dementia and currently remains without a curative or preventive treatment. Characteristic pathological features include amyloid-β (Aβ-) accumulation, neuroinflammation, synaptic ... -
Tau-Protein im Liquor cerebrospinalis in der Differenzialdiagnostik bei Morbus Alzheimer und sporadischer Creutzfeldt- Jakob-Krankheit
(2025-05-12)In der Diagnostik der Alzheimer-Demenz (AD) hat sich das totale Tau (t-Tau) im Liquor als ein wichtiges diagnostisches Mittel etabliert. Allerdings wurden auch bei Patient*innen mit Creutzfeldt-Jakob-Krankheit (CJK) stark ... -
Detektion von Nebenbefunden bei röntgenologischer Bildgebung in der kieferorthopädischen Praxis: eine fragebogenbasierte Untersuchung
(2025-05-09)Background: In orthodontic practice, radiographs with large fields of view - such as orthopantomogram (OPT) and lateral cephalogram (LC) radiographs - are routinely acquired and assessed. The reliability of identifying ... -
Cross-National Analysis of IVF Registry Data
(2025-05-08)Approximately 15% (1 in 6) of couples worldwide face infertility issues, and assisted reproductive technology (ART), which is now adopted globally, has become a key method to address these challenges. Various in-vitro ... -
Der Effekt von Erythropoetin auf das Überleben von Gehirnnervenzellen der Locusta migratoria nach Schädigung durch UV-Strahlung
(2025-05-08)Erythropoietin (Epo) is a well-known candidate for neuroprotection due to its anti-apoptotic properties. One limiting factor in previous studies has been thromboembolic side effects. Various receptors and signaling pathways ... -
Das Potenzial spezifischer methylierter DNA im Blut als Biomarker für die Mortalität bei Herzinsuffizienz mit erhaltener Ejektionsfraktion
(2025-05-07)Chronic heart failure is a leading health risk worldwide for the increasingly ageing population. Patients with heart failure with preserved ejection fraction (HFpEF) account for around half of all cases. Making a valid ... -
Bacteriorhodopsin-like cation channelrhodopsin based optogenetic tools for the future optical cochlear implant
(2025-05-07)Deafness is a widespread and severe condition. Electrical cochlear implants, which use electrical stimulation of the auditory nerve, enable speech comprehension in those patients suffering from sensorineural hearing loss. ... -
Kardiale Magnetresonanztomographie: Semiautomatische dreidimensionale Analyse und Visualisierung linksatrialer struktureller Veränderungen
(2025-04-30)Background: Catheter ablation is an established treatment for atrial fibrillation (AF), yet its efficacy, particularly for first-time procedures, is influenced by the degree of left atrial (LA) structural remodeling - most ... -
Identification of differentially m6A methylated circRNAs in patient derived RBM20 mutated and control iPS-Cardiomyocytes
(2025-04-30)Approximately 5% of dilated cardiomyopathies are caused by a mutation in the RBM20 gene, which encodes a protein involved in the splicing of cardiac specific titin and formation of cTTNs, the titin specific circRNA. Although ... -
Auswirkung der klinischen MRT-Auswertung auf die Detektionsrate des Prostatakarzinoms im Rahmen der MRT/TRUS-Fusionsbiopsie der Prostata
(2025-04-30)Prostate carcinoma is the most frequently diagnosed cancer in men in Germany. It is crucial to recognise clinically significant carcinomas at an early stage. Prostate biopsy is the preferred diagnostic method for this. ... -
Varianten im Dihydropyrimidin-Dehydrogenase-Gen (DPYD) bei Patienten mit Rektumkarzinomen unter adjuvanter, 5-FU-haltiger Chemotherapie – eine monozentrische Analyse aus der GAST-05-Studie
(2025-04-29)In this monocentric posthoc study the impact of occult mutational DPYD status in patients with adenocarcinomas (stages ≥ II) of the upper rectum was investigated towards the occurrence of CTC-AEs (Common-Toxicity-Criteri ... -
Auswirkungen der Maskenpflicht auf die Arzt-Patienten-Kommunikation bei Patienten mit Tumoren im Mund-, Kiefer- und Gesichtsbereich
(2025-04-29)To contain the rapid spread of SARS-CoV-2, the mandatory wearing of face masks was a key component of COVID-19 safety measures during the pandemic. This mask mandate was repeatedly subject to controversial debate. As a ... -
Proteomische Analyse des kleinzelligen Lungenkarzinoms
(2025-04-28)Small cell lung carcinoma belonging to the group of neuroendocrine tumors of the lung is an aggressive and rapidly progressing tumor disease with a poor prognosis. Significant progress in the treatment of patients with ... -
Neurodegenerationsmarker im Verlauf eines 6-wöchigen hochfrequenten standardisierten Sportprogramms (SIWAS) in 3 Gruppen Psychiatrischer Erkrankungen
(2025-04-28)This study investigated the effects of a six-week, structured physical exercise program on neurodegenerative biomarkers in patients with schizophrenia, depression, or substance use disorders. A total of 61 participants ...