Dokumente Molekulare Medizin nach Titel
Anzeige 24-43 von 242
-
Cancer drugs targeting DNA replication: Molecular strategies to enhance specificity and efficacy
(2020-07-10)The DNA molecule stands at the center of cancer origin and treatment. Cancer cells are addicted to DNA mutations and DNA replication, therapeutic non-responders are often based on the rate of mutations and ability to ... -
Cardiac and fibroblastic properties after HIF-1α stabilization
(2015-06-01)The cellular oxygen sensing prolyl-4-hydroxylase domain proteins (PHDs) are essential regulators of the α-subunit of hypoxia-inducible transcription factors (HIFs) which are known to induce a variety of genes affecting ... -
Cardiac fibroblast phenotype regulation in engineered connective tissues with a special focus on ER adaptation and stress
(2023-03-23)Cardiovascular diseases cause adverse myocardial remodeling due to cardiomyocyte loss and modifications to the extracellular matrix (ECM), which can ultimately lead to contractile dysfunction and pathological cardiac ... -
Cardiac microvascular dysfunction in diabetes mellitus: elucidation of molecular determinants and therapeutic targets
(2023-03-09)Microvascular dysfunction is a pathological hallmark of the diabetic myocardium, and is central to the etiology of diabetes-associated cardiac events. Herein, previous studies highlighted the role of the vasoactive micro-RNA ... -
Cellular and subcellular analysis of peripheral neuropathy caused by peroxisomal dysfunction in mice
(2016-11-09)Fast signal propagation and long-term integrity of myelinated axons rely on precise axo-glial interactions. A role for myelin-associated peroxisomes in facilitating axonal support by glial cells was demonstrated in a mouse ... -
Cellular and transcriptional profiling of hypoxic cells in the brain
(2021-07-08)Hypoxia is a critical regulator of the hypoxic response driving neurodevelop-ment, angiogenesis, hematopoiesis, and tissue regeneration. In the central nervous system, oxygen is a fundamental constituent of cellular ... -
Cellular immunotherapy of pancreatic ductal adenocarcinoma: Discovery and evaluation of novel target candidates
(2021-03-19)Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor prognosis and limited treatment options. In recent years, chimeric antigen receptor (CAR) T cells have achieved remarkable success in the ... -
Cellular prion protein in Alzheimer’s disease: Molecular insights and behavior implications
(2024-01-11)Alzheimer’s disease (AD) poses a substantial and increasing challenge, particularly due to our aging population, and its underlaying pathophysiology remains a topic of ongoing debate. Cellular prion protein (PrPC) has ... -
Cellular response to compartmentalized redox alterations
(2022-08-24)Reactive oxygen species (ROS) were considered only as toxic and unavoidable by-products of aerobic cell life in the past. Nevertheless, their significance for cellular signalling is currently widely accepted and extensively ... -
Cellular responses mediated by the transcription factor STAT1 in murine inflammatory diseases
(2017-01-12)The intracellular transduction of interferon signals from the plasma membrane to the nucleus is mediated by signal transducer and activator of transcription 1 (STAT1) which acts in tetrameric form as a transcription factor ... -
Central nervous system intrinsic inflammation as driver and therapeutic target of progression in multiple sclerosis
(2022-01-25)Controlling disease progression in multiple sclerosis (MS) remains a major challenge. Progression of MS is defined as an increase in neurological disability occurring independently of relapses or focal MRI-detectable ... -
Centrosome integrity as a determinant of replication stress
(2020-01-29)The centrosome functions as a microtubule-nucleating organelle for the mitotic spindle. Like the whole genome, centrosomes require accurate replication once per cell cycle. Here we show that the impairment of centrosome ... -
Characterization and Application of Bioengineered Heart Muscle as a New Tool to Study Human Heart Development and Disease
(2016-09-20)Proof-of-concept for the generation of a bioengineered heart muscle (BHM) directly from human pluripotent stem cells (hPSCs) as a model to simulate human heart muscle development was introduced recently by our lab. BHMs ... -
Characterization of blood-brain barrier disruption in a focal model of neuromyelitis optica
(2015-11-20)Neuromyelitis optica (NMO) is a demyelinating autoimmune disease of the central nervous system (CNS), with serum anti-aquaporin4 (AQP4) antibodies (Ab) detected in the majority of patients. Binding of NMO-Ab to AQP4 results ... -
Characterization of cardiac progenitor cell activity in engineered heart muscle
(2016-06-21)The heart has been considered a post-mitotic organ incapable of regeneration upon injury. Recent findings suggest that the heart contains cardiac progenitor cells (CPCs) with the potential to give rise to cardiovascular ... -
Characterization of myelin-specific autoantibodies in an EAE mouse model
(2023-10-02)Abstract Autoimmune diseases are caused by an attack of the immune system against own tissues, but the exact effector mechanisms may vary between individual diseases and are not yet fully understood. The autoimmune disease ... -
Characterization of peroxisomes and peroxisome deficient cell lines by super-resolution microscopy and biochemical methods
(2016-11-25)Stimulated Transmission Emission Depletion (STED) microscopy was used to characterize the nanoscopic morphology of wild-type peroxisomes under normal and proliferative conditions in mammalian cells and in yeast Saccharomyces ... -
Characterization of the MIR23A Cluster in Diffuse Large B Cell Lymphoma
(2017-08-11)During B cell maturation within the germinal centers of lymph nodes, genetical alterations, such as chromosomal translocations and mutations are introduced into the genome in order to increase the B cell receptor (BCR) ... -
Characterization of the multifunctional XPG protein during Nucleotide-excision-repair
(2014-06-03)Xeroderma pigmentosum (XP), a cancer model disease, is the perfect proof for the existing model of carcinogenesis activated by mutations. All patients share a defect in Nucleotide excision repair (NER). The gene, which is ... -
Charakterisierung induzierter, kolorektaler Lebermetastasen in einem Mausmodell und Einfluss von Makrophagenphänotypen auf die Tumorprogression
(2017-01-12)The liver is considered to be the primary target organ for hematogenous spread of colorectal cancer (CRC), as more than 50 % of affected patients develop liver metastases during the course of their tumor disease. Due to ...