Dokumente Molekulare Medizin nach Titel
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Hedgehog signaling in cutaneous squamous cell carcinoma
(2018-01-24)Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin tumor in humans with increasing incidence. cSCC is a result of malignant transformation of epidermal cells with ultraviolet (UV) radiation ... -
HID1 as a novel disease-causing gene in early onset neurological disorders: molecular, functional and phenotypic studies
(2022-09-07)Rare neurological diseases with genetic causes are gaining relevance for child morbidity and mortality due to improvements in health care, prevention and treatment of conventional life-limiting diseases in infants. Emerging ... -
High throughput strategies for electrophysiological characterisation of cardiomyocytes
(2023-08-22)Personalised medicine describes the customised application of medical treatment at a patient-specific level. This type of precision medicine stratifies patients based on their specific genotype or phenotype for targeted ... -
Hodgkin lymphoma secreted factors determine macrophage polarization and function
(2018-09-14)Hodgkin lymphoma (HL) is a unique entity where the fraction of malignant cells accounts for only 1 % of the tumor. The cells are embedded in a complex background of non-neoplastic immune infiltrates. Profound interactions ... -
HSP90-stabilized proteins as therapeutic targets in cancer
(2021-06-25)Although cancer is among the most common causes of death worldwide, successful treatment options for most cancer entities remain elusive, raising the need for novel therapies. One attractive target of current drug candidates ... -
Human induced pluripotent stem cell models used in the study of doxorubicin-induced cardiomyopathy
(2020-06-24)Doxorubicin (DOX) has been used for decades to treat hematopoietic and solid tumors, although, in a subset of cancer survivors, it causes cardiotoxicity decades after treatment. The mechanisms of anthracycline-induced ... -
Identification and Characterization of autophagic and non-autophagic Interaction Partners of Atg18
(2021-06-03)The PROPPIN Atg18 belongs to the WD40 repeat containing family and folds into a typical seven-bladed beta-propeller. Conserved regions at blade 5 and 6 allow for binding to phosphatidylinositolphosphates and mediate the ... -
Identification of genes regulated in target organs of acute graft versus host disease in different organs in different species
(2016-10-13)Major histocompatibility complex (MHC) matching is essential to reduce the risk of graft versus host disease (GvHD) but minor histocompatibility antigens (mHags) also affect the outcome of hematopoietic stem cell transplantation ... -
IFNβ as regulator of CD14/TLR4-mediated microglial responses to CNS infection and damage
(2017-02-15)Microglia are the innate immune cells of the central nervous system (CNS). They are capable of sensing infection and damage through various receptors and consequently trigger an appropriate immune response. This includes ... -
Immunological properties of parthenogenetic stem cell derived cardiomyocytes and their application in cardiac tissue engineering
(2016-06-20)Cardiovascular diseases and their long term consequences constitute serious health and economic burdens. Although promising new therapeutic approaches to ameliorate the detrimental consequences have been introduced, there ... -
Immunopathogenesis of cortical demyelination in Multiple Sclerosis
(2015-11-20)Cortical demyelination is a key pathological feature of multiple sclerosis (MS) and clinically linked to cognitive deficits and disability progression. Extensive band-like subpial demyelination is even a specific feature ... -
Immunotherapy of solid tumors: multimodal imaging strategies for chimeric antigen receptor T cell tracking in the tumor microenvironment
(2021-08-02)Immunotherapy is an emerging building block of modern oncology, after chimeric antigen receptor (CAR) T cells demonstrated groundbreaking survival rates in hematological malignancies. However, therapy success in more common ... -
Impact of N-terminally truncated Aß4-42 on memory and synaptic plasticity - Tg4-42 a new mouse model of Alzheimer's disease
(2015-01-14)A heterogeneous mixture of amyloid beta (Aβ) variants exists in Alzheimer’s disease (AD) brains. So far, little is known how individual Aβ species contribute to development and progression of this neurodegenerative disorder. ... -
Impact of natalizumab therapy on human pathology and an animal model of multiple sclerosis (EAE) with special focus on B cell / plasma cell inflammation
(2014-03-13)Multiple sclerosis (MS) is considered to be a T cell-mediated demyelinating disease. However, there is increasing evidence for the involvement of B cells and plasma cells in MS pathogenesis: for instance, B cells and plasma ... -
Impaired chromosome integrity caused by mutations in members of the BTRR complex
(2023-10-17)Bloom syndrome (BS) is an autosomal recessive rare disorder clinically characterized by primary microcephaly, growth deficiency, short stature, photosensitivity, immunodeficiency, and cancer predisposition. BS is caused ... -
Importance of CXCL12 and CXCR4 in radiotherapy of head and neck cancer, considering the association with HPV-infection
(2015-09-10)p16INK4A expression is an important, independent prognostic marker in HNSCC patients. We observed a strong correlation between tumour HPV status, particularly HPV-16, and p16INK4A expression. Accordingly, our data clearly ... -
Improving Therapies of Rhabdomyosarcoma
(2016-01-08)Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and occurs as two major subtypes; embryonal (ERMS) and alveolar RMS (ARMS). Therapies of RMS typically combine surgical excision or local irradiation ... -
In vivo application of CRISPR/Cas9 mediated gene re-expression in the failing mouse and human myocardium
(2022-11-17)Transcriptional adaptation in cardiomyocytes precedes cellular deterioration and functional decline upon myocardial stress and damage resulting in heart failure progression. The re-activation of WNT/β-catenin (CTNNB1) ... -
In vivo imaging of the voltage-gated potassium channel Kv10.1 utilizing SPECT in combination with radiolabeled antibodies
(2015-11-19)The detection of tumors in an early phase of tumor development is an important achievement to improve the overall prognosis of the patient. Besides accurate information of tumor load and spread, the retrieval of the ... -
Induced pluripotent stem cell-derived cardiomyocytes as model for studying CPVT caused by mutations in RYR2
(2016-12-02)Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe hereditary cardiac ion-channel disease, which is caused by mutations in ryanodine receptor 2 (RYR2) or calsequestrin 2 (CASQ2). After β-adrenergic ...