Dokumente Molekulare Medizin nach Titel
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Identification and Characterization of autophagic and non-autophagic Interaction Partners of Atg18
(2021-06-03)The PROPPIN Atg18 belongs to the WD40 repeat containing family and folds into a typical seven-bladed beta-propeller. Conserved regions at blade 5 and 6 allow for binding to phosphatidylinositolphosphates and mediate the ... -
Identification of genes regulated in target organs of acute graft versus host disease in different organs in different species
(2016-10-13)Major histocompatibility complex (MHC) matching is essential to reduce the risk of graft versus host disease (GvHD) but minor histocompatibility antigens (mHags) also affect the outcome of hematopoietic stem cell transplantation ... -
IFNβ as regulator of CD14/TLR4-mediated microglial responses to CNS infection and damage
(2017-02-15)Microglia are the innate immune cells of the central nervous system (CNS). They are capable of sensing infection and damage through various receptors and consequently trigger an appropriate immune response. This includes ... -
Immunological properties of parthenogenetic stem cell derived cardiomyocytes and their application in cardiac tissue engineering
(2016-06-20)Cardiovascular diseases and their long term consequences constitute serious health and economic burdens. Although promising new therapeutic approaches to ameliorate the detrimental consequences have been introduced, there ... -
Immunopathogenesis of cortical demyelination in Multiple Sclerosis
(2015-11-20)Cortical demyelination is a key pathological feature of multiple sclerosis (MS) and clinically linked to cognitive deficits and disability progression. Extensive band-like subpial demyelination is even a specific feature ... -
Immunotherapy of solid tumors: multimodal imaging strategies for chimeric antigen receptor T cell tracking in the tumor microenvironment
(2021-08-02)Immunotherapy is an emerging building block of modern oncology, after chimeric antigen receptor (CAR) T cells demonstrated groundbreaking survival rates in hematological malignancies. However, therapy success in more common ... -
Impact of N-terminally truncated Aß4-42 on memory and synaptic plasticity - Tg4-42 a new mouse model of Alzheimer's disease
(2015-01-14)A heterogeneous mixture of amyloid beta (Aβ) variants exists in Alzheimer’s disease (AD) brains. So far, little is known how individual Aβ species contribute to development and progression of this neurodegenerative disorder. ... -
Impact of natalizumab therapy on human pathology and an animal model of multiple sclerosis (EAE) with special focus on B cell / plasma cell inflammation
(2014-03-13)Multiple sclerosis (MS) is considered to be a T cell-mediated demyelinating disease. However, there is increasing evidence for the involvement of B cells and plasma cells in MS pathogenesis: for instance, B cells and plasma ... -
Impaired chromosome integrity caused by mutations in members of the BTRR complex
(2023-10-17)Bloom syndrome (BS) is an autosomal recessive rare disorder clinically characterized by primary microcephaly, growth deficiency, short stature, photosensitivity, immunodeficiency, and cancer predisposition. BS is caused ... -
Importance of CXCL12 and CXCR4 in radiotherapy of head and neck cancer, considering the association with HPV-infection
(2015-09-10)p16INK4A expression is an important, independent prognostic marker in HNSCC patients. We observed a strong correlation between tumour HPV status, particularly HPV-16, and p16INK4A expression. Accordingly, our data clearly ... -
Improving Therapies of Rhabdomyosarcoma
(2016-01-08)Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and occurs as two major subtypes; embryonal (ERMS) and alveolar RMS (ARMS). Therapies of RMS typically combine surgical excision or local irradiation ... -
In vivo application of CRISPR/Cas9 mediated gene re-expression in the failing mouse and human myocardium
(2022-11-17)Transcriptional adaptation in cardiomyocytes precedes cellular deterioration and functional decline upon myocardial stress and damage resulting in heart failure progression. The re-activation of WNT/β-catenin (CTNNB1) ... -
In vivo imaging of the voltage-gated potassium channel Kv10.1 utilizing SPECT in combination with radiolabeled antibodies
(2015-11-19)The detection of tumors in an early phase of tumor development is an important achievement to improve the overall prognosis of the patient. Besides accurate information of tumor load and spread, the retrieval of the ... -
Induced pluripotent stem cell-derived cardiomyocytes as model for studying CPVT caused by mutations in RYR2
(2016-12-02)Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe hereditary cardiac ion-channel disease, which is caused by mutations in ryanodine receptor 2 (RYR2) or calsequestrin 2 (CASQ2). After β-adrenergic ... -
Induced pluripotent stem cells from patients with hypoplastic left heart syndrome (HLHS) as a model to study functional contribution of endothelial-mesenchymal transition (EndMT) in HLHS
(2016-11-30)Hypoplastic left heart syndrome (HLHS) is one of the most lethal congenital heart diseases (CHD) and its pathological mechanism remains unclear. Endocardial fibroelastosis (EFE) is a hallmark of HLHS which impairs myocardial ... -
Influence of long-term acid adaptation and acute microenvironmental pH changes on Pancreatic Ductal Adenocarcinoma (PDAC) development, progression and invasion
(2023-08-16)Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers worldwide and it is predicted to be the second leading cause of cancer-related deaths by 2030. PDAC development is strictly linked to the ... -
Insights into early biogenesis steps of the human small mitochondrial ribosomal subunit
(2021-06-28)The rise of high-resolution cryo-EM structures of the human mitochondrial ribosome increased the understanding of the function and assembly. As the mitochondrial ribosome differs in structure and composition compared to ... -
Interaction of hepatic uptake transporters with antineoplastic compounds and regulation of the expression of organic cation transporter 3 in renal carcinoma cells
(2015-02-06)The ability of a compound to exert its antineoplastic activity is determined by the amount of its accumulation inside the cell, a process largely dependent on the transporter proteins which are responsible for the passage ... -
Interfering with critical steps of the viral replication cycle to diminish SARS-CoV-2 propagation
(2022-10-07)The ongoing COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has so far infected more than 0.5 billion people worldwide, with at least 6.3 million deaths, and constitutes one of the largest global health ... -
Interplay of ARID1A and EGFR signaling in controlling acinar cell reprogramming in the pancreas
(2021-03-18)Based on a high degree of cellular plasticity and triggered by external (e.g. inflammation) or internal (e.g. oncogenic pressure) signals, pancreatic acinar cells can undergo reprogramming processes resulting in acinar-to-ductal ...