Dokumente Molekulare Medizin nach Titel
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MCL-1, BCL-xL and Casp-3 as key regulators in thymus homeostasis and thymic epithelial tumors
(2021-12-23)As a primary lymphatic organ, the thymus is responsible for T cell development and the establishment of the adaptive immune system. The homeostasis and proper function of the thymus epithelium require the strict regulation ... -
Mechanical regulation of cardiac fibroblasts.
(2021-08-09)Cardiac fibrosis progressively contributes to heart failure (HF). Yet, its complex nature still lacks a more comprehensive understanding. One main hurdle is the lack of representative human models providing insights into ... -
Mechanisms of communication from mitochondria to lysosomes
(2017-03-24)The importance of mitochondria for cellular respiration, ATP synthesis and involvement in cell signaling pathways impacting cell proliferation, differentiation or death is now recognized. Due to the broad roles of mitochondria ... -
Mechanisms of Glucocorticoids in the modulation of Graft-versus-Host Disease and the Graft-versus-Leukemia Reaction
(2020-07-31)Acute graft-versus-host disease (aGvHD) is a severe complication that frequently occurs after allogeneic hematopoietic stem cell transplantation and results in a high transplant-related morbidity and mortality. Glucocorticoids ... -
Mechanisms underlying low flow-low gradient aortic stenosis
(2020-11-09)Aortic stenosis (AS) remains the most common valvular disease in the elderly with an increasing prevalence, owing to the predominance of degenerative etiologies; hence, represents a major public health burden. The majority ... -
Melanoma-associated brain metastasis: Molecular mechanisms and therapeutic options
(2022-04-14)Melanoma is the deadliest of skin cancers and exhibits the highest level of brain tropism of all cancer types. Melanoma brain metastases (MBMs) are diagnosed in no less than 50 % of patients with stage IV melanoma, although ... -
Migratory Cues For Encephalitogenic Effector T Cells Within The CNS During The Different Phases Of EAE
(2013-06-17)In multiple sclerosis (MS), encephalitogenic T cells are considered to breach distinct cerebral barriers in order to gain access to their target tissue, the CNS. However, it remains poorly understood exactly how auto-reactive ... -
Mild production of reactive oxygen species reversibly affects the metabolism and function of the heart
(2023-01-25)Reactive oxygen species (ROS) are molecular oxygen derivatives that are produced as an attribute of aerobic life. The relationship between elevated levels of ROS and heart failure (HF) has been extensively studied. However, ... -
MiRNAs and tumor suppressors form a gene regulatory network to protect multiciliogenesis
(2019-01-10)Multiple motile cilia are present on specialized epithelial cells lining the airways, reproductive ducts, and brain ventricles. Cilia beating contributes to fluid movement and particle transport along the multiciliated ... -
Mitochondrial nucleoid distribution and its relation to presynaptic activity investigated by correlative light microscopy
(2023-10-11)Mitochondria are essential for eukaryotic life, because they provide most of the energy for a variety of cellular processes. Especially high energy demanding cells and tissues like the muscles and the neuronal cells of the ... -
Modeling Takotsubo syndrome with patient-specific induced pluripotent stem cell-derived cardiomyocytes
(2021-10-18)Takotsubo syndrome (TTS) is a severe acute heart disease presumably caused by high catecholamine levels resulting in wall motion abnormalities of the left ventricle. Despite the severe phenotype of TTS, the exact disease ... -
Modulation of Cardiac Fibroblast to Myofibroblast Transition by Rho-Associated Kinases ROCK1 and ROCK2
(2016-10-25)Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC. They play a critical role in the pathogenesis of myocardial fibrosis; however, their ... -
Modulation of cardiac function by oxidized type I protein kinase A
(2017-03-31)L-type Ca2+ channels (LTCC) are known to be involved in the dysregulation of intracellular Ca2+ handling in heart failure (HF) contributing to contractile dysfunction and arrhythmias. Beside alteration in subcellular ... -
Modulation of HSF1 activity by p53 and its impact in cancer therapies
(2023-07-13)The tumor suppressor p53 (TP53) is mutated in ~70 % of colorectal cancer (CRC) cases. Of these cases, approximately 80 % undergo subsequent p53 loss-of-heterozygosity (p53LOH), losing the remaining wildtype p53 (WTp53) ... -
Modulation of remyelination by adaptive inflammation and electrical stimulation
(2017-06-29)Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease of the central nervous system (CNS). Typical characteristics of MS are blood-brain barrier (BBB) breakdown, invasion of peripheral immune cells, ... -
Molecular determinants for the outcome in gemcitabine-treated pancreatic cancer
(2015-12-07)Pancreatic ductal adenocarcinoma (PDAC) is a mostly lethal disease which represents the fourth common cause of all deaths related to cancer. The nucleoside analogue gemcitabine constitutes a currently widely used treatment ... -
Molecular mechanisms of TBX5-related conduction disorders
(2021-08-24)Background Cardiovascular disease is a common cause of death. About 60 % of cardiovascular mortality is attributable to sudden cardiac death, mostly caused by arrhythmia. The origin of arrhythmia can be an underlying ... -
Molecular pathogenesis underlying syndromic forms of primary microcephaly
(2020-01-08)Microcephaly describes a reduced brain size in patients that manifests in an evidently reduced head circumference compared to healthy individuals of same age, sex and ethnicity. Even though microcephaly is still considered ... -
Myeloid corticoid receptors in CNS autoimmunity: Old targets for novel therapies
(2016-10-21)Since the 1950s, glucocorticoids (GCs) have been the most widely employed drugs in the treatment of inflammatory and autoimmune disorders, such as multiple sclerosis (MS). Short-time application of high-dose GCs is the ... -
Myofibroblast differentiation in hypoxia: a novel role for ArhGAP29
(2019-05-20)Myofibroblasts are crucial for normal wound healing and tissue remodelling and play an es-sential role in the pathogenesis of ischemic tissue fibrosis. Due to their contractile features, myofibroblasts support wound closure; ...