Dokumente Molekulare Medizin nach Titel
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Knockdown of NEAT1 prevents lipid droplet accumulation in microglia after ischemic stroke via autophagy
(2023-10-06)Lipid droplets (LDs), lipid-storing organelles containing neutral lipids such as glycerolipids and cholesterol, are increasingly accepted as structural markers of inflammation. The nuclear paraspeckle assembly transcript ... -
Lactate dehydrogenase is C-terminally extended by stop codon read-through which targets this isoform into the peroxisomes
(2016-08-12)In this work, the functional significance of stop codon read-through was investigated in relation to the human peroxisomes. When the ribosomes translating a messenger RNA encounter a stop codon, they usually stop the ... -
Live Analysis of the Role of B cells in Experimental Autoimmune Encephalomyelitis
(2016-01-08)During the last years it has become increasingly clear that autoantigen-specific B cells play a pathogenic role in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). However, their ... -
Local cAMP dynamics in the SERCA2a signalling complex
(2014-11-13)3’,5’-cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that regulates multiple physiological functions by acting in distinct subcellular microdomains. Over the last few years, several targeted biosensors ... -
MCL-1, BCL-xL and Casp-3 as key regulators in thymus homeostasis and thymic epithelial tumors
(2021-12-23)As a primary lymphatic organ, the thymus is responsible for T cell development and the establishment of the adaptive immune system. The homeostasis and proper function of the thymus epithelium require the strict regulation ... -
Mechanical regulation of cardiac fibroblasts.
(2021-08-09)Cardiac fibrosis progressively contributes to heart failure (HF). Yet, its complex nature still lacks a more comprehensive understanding. One main hurdle is the lack of representative human models providing insights into ... -
Mechanisms of communication from mitochondria to lysosomes
(2017-03-24)The importance of mitochondria for cellular respiration, ATP synthesis and involvement in cell signaling pathways impacting cell proliferation, differentiation or death is now recognized. Due to the broad roles of mitochondria ... -
Mechanisms of Glucocorticoids in the modulation of Graft-versus-Host Disease and the Graft-versus-Leukemia Reaction
(2020-07-31)Acute graft-versus-host disease (aGvHD) is a severe complication that frequently occurs after allogeneic hematopoietic stem cell transplantation and results in a high transplant-related morbidity and mortality. Glucocorticoids ... -
Mechanisms underlying low flow-low gradient aortic stenosis
(2020-11-09)Aortic stenosis (AS) remains the most common valvular disease in the elderly with an increasing prevalence, owing to the predominance of degenerative etiologies; hence, represents a major public health burden. The majority ... -
Melanoma-associated brain metastasis: Molecular mechanisms and therapeutic options
(2022-04-14)Melanoma is the deadliest of skin cancers and exhibits the highest level of brain tropism of all cancer types. Melanoma brain metastases (MBMs) are diagnosed in no less than 50 % of patients with stage IV melanoma, although ... -
Migratory Cues For Encephalitogenic Effector T Cells Within The CNS During The Different Phases Of EAE
(2013-06-17)In multiple sclerosis (MS), encephalitogenic T cells are considered to breach distinct cerebral barriers in order to gain access to their target tissue, the CNS. However, it remains poorly understood exactly how auto-reactive ... -
Mild production of reactive oxygen species reversibly affects the metabolism and function of the heart
(2023-01-25)Reactive oxygen species (ROS) are molecular oxygen derivatives that are produced as an attribute of aerobic life. The relationship between elevated levels of ROS and heart failure (HF) has been extensively studied. However, ... -
MiRNAs and tumor suppressors form a gene regulatory network to protect multiciliogenesis
(2019-01-10)Multiple motile cilia are present on specialized epithelial cells lining the airways, reproductive ducts, and brain ventricles. Cilia beating contributes to fluid movement and particle transport along the multiciliated ... -
Mitochondrial nucleoid distribution and its relation to presynaptic activity investigated by correlative light microscopy
(2023-10-11)Mitochondria are essential for eukaryotic life, because they provide most of the energy for a variety of cellular processes. Especially high energy demanding cells and tissues like the muscles and the neuronal cells of the ... -
Modeling Takotsubo syndrome with patient-specific induced pluripotent stem cell-derived cardiomyocytes
(2021-10-18)Takotsubo syndrome (TTS) is a severe acute heart disease presumably caused by high catecholamine levels resulting in wall motion abnormalities of the left ventricle. Despite the severe phenotype of TTS, the exact disease ... -
Modulation of Cardiac Fibroblast to Myofibroblast Transition by Rho-Associated Kinases ROCK1 and ROCK2
(2016-10-25)Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC. They play a critical role in the pathogenesis of myocardial fibrosis; however, their ... -
Modulation of cardiac function by oxidized type I protein kinase A
(2017-03-31)L-type Ca2+ channels (LTCC) are known to be involved in the dysregulation of intracellular Ca2+ handling in heart failure (HF) contributing to contractile dysfunction and arrhythmias. Beside alteration in subcellular ... -
Modulation of HSF1 activity by p53 and its impact in cancer therapies
(2023-07-13)The tumor suppressor p53 (TP53) is mutated in ~70 % of colorectal cancer (CRC) cases. Of these cases, approximately 80 % undergo subsequent p53 loss-of-heterozygosity (p53LOH), losing the remaining wildtype p53 (WTp53) ... -
Modulation of remyelination by adaptive inflammation and electrical stimulation
(2017-06-29)Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease of the central nervous system (CNS). Typical characteristics of MS are blood-brain barrier (BBB) breakdown, invasion of peripheral immune cells, ... -
Molecular determinants for the outcome in gemcitabine-treated pancreatic cancer
(2015-12-07)Pancreatic ductal adenocarcinoma (PDAC) is a mostly lethal disease which represents the fourth common cause of all deaths related to cancer. The nucleoside analogue gemcitabine constitutes a currently widely used treatment ...