Dokumente Molekulare Medizin nach Titel
Anzeige 83-102 von 242
-
Fibroblast-Cardiomyocyte Cross-Talk in Heart Muscle Formation and Function
(2019-02-01)Cardiac fibroblasts make up a considerable fraction of the total heart cell content. How cardiac fibroblasts signaling affects heart muscle function in normal heart development and disease remains, however, largely unresolved. ... -
Fibroblasts in colorectal cancer: Subtype diversity and immune cell modulation
(2024-02-20)Despite significant advances in early detection and treatment, colorectal cancer (CRC) remains one of the deadliest cancers worldwide. In case of advanced disease, immunotherapies, such as immune checkpoint inhibitors ... -
From Chromatin Readers to Heart Failure: BET Protein Family Members in Cardiac Remodeling
(2019-05-16)Heart failure (HF) is the pathologic inability of the heart to supply the body with sufficient amounts of oxygen-rich blood. This increasingly common, life-threatening condition occurs in the final stage of various cardiac ... -
From the centrosome to the nuclear envelope and beyond: insights into the role of CRM1 in adenoviral genome delivery
(2020-07-09)Adenoviruses (AdV) are DNA viruses that replicate in the nucleus of their host cell. Due to the limited coding capacity, they have to take advantage of cellular mechanisms in order to perform their infection cycle. During ... -
Functional analysis of ryanodine receptor 2 mutations in induced pluripotent stem cell-derived cardiomyocytes from CPVT patients
(2017-03-30)Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an ion channel disorder in the heart, which is characterized by abnormal calcium handling, ventricular arrhythmias, and sudden cardiac death. This inherited ... -
Functional and diagnostic relevance of FGFR1-dependent signaling pathways in squamous cell lung cancer
(2020-09-22)Lung cancer continuous to be the leading cause of cancer-related death worldwide. A relatively new and effective approach of treating lung cancer is achieved through targeting specific molecular alterations in lung cancer ... -
Functional characterization of B- and T lymphocytes after aCD20 treatment in two different EAE models
(2017-09-25)Multiple sclerosis (MS) is one of the most common causes of persisting disability in young adults. Its clinical course can be heterogeneous with a varying extent of inflammatory central nervous system (CNS) lesions, ... -
Functional characterization of genetic polymorphisms in the organic cation transporter OCT1 with a special focus on the substrate-specific effects of the M420del polymorphism
(2016-06-06)The human organic cation transporter 1 (OCT1) is strongly expressed in the sinusoidal membrane of hepatocytes. OCT1 mediates the uptake of drugs and exogenous substances with cationic or weak basic structures into the ... -
Functional effects of the MICA-129 dimorphism on NK cell activity and association with the outcome of hematopoietic stem cell transplantation
(2014-05-06)The MHC class I chain-related molecule A (MICA) is a highly polymorphic ligand for the activating natural killer (NK) cell receptor NKG2D (NK group 2, member D). The single nucleotide polymorphism (SNP) at position 454 (A ... -
Functional proteome analysis of age associated PrPC knockout mice liver along with regulatory response of cytoskeleton associated tau protein and fatty liver disease.
(2015-12-03)PrPC is a membrane associated cellular glycoprotein. Its mis-folded form, PrPSc causes a set of neurodegenerative diseases called transmissible spongiform encephalopathies (TSEs). PrPC is abundantly expressed in the brain ... -
Functional relevance of spontaneous alternative splice variants of xeroderma pigmentosum genes: Prognostic marker for skin cancer risk and disease outcome?
(2017-05-05)The nucleotide excision repair (NER) pathway is a central DNA repair mechanism to repair a variety of bulky DNA lesions. Accumulation of these types of damage all over the genome results in the development of a cancer prone ... -
Gene-expression control in early and late-onset dementia
(2022-10-05)Mutations in genes that control epigenetic gene expression, especially the machinery that controls Histone 3 lysine 4 (H3K4me) methylation, are over-represented in intellectual disability disorders. It is mediated by both ... -
Genetic polymorphisms in genes regulating renal ion excretion and diuretic drug effects
(2014-07-17)Regulation of human salt and fluid homeostasis is of basic biological importance. Kidney functions allow surviving under a wide variety of conditions with high or low salt diets and with high or low intake of fluids, even ... -
GSK3β-mediated DNA damage repair in pancreatic cancer
(2021-11-24)In this study we aimed to determine a deeper mechanistic understanding of GSK3β and its influence on pancreatic cancer behavior. Specifically, we examined the effect of GSK3β on transcriptional regulation and function ... -
Hedgehog signaling in cutaneous squamous cell carcinoma
(2018-01-24)Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin tumor in humans with increasing incidence. cSCC is a result of malignant transformation of epidermal cells with ultraviolet (UV) radiation ... -
HID1 as a novel disease-causing gene in early onset neurological disorders: molecular, functional and phenotypic studies
(2022-09-07)Rare neurological diseases with genetic causes are gaining relevance for child morbidity and mortality due to improvements in health care, prevention and treatment of conventional life-limiting diseases in infants. Emerging ... -
High throughput strategies for electrophysiological characterisation of cardiomyocytes
(2023-08-22)Personalised medicine describes the customised application of medical treatment at a patient-specific level. This type of precision medicine stratifies patients based on their specific genotype or phenotype for targeted ... -
Hodgkin lymphoma secreted factors determine macrophage polarization and function
(2018-09-14)Hodgkin lymphoma (HL) is a unique entity where the fraction of malignant cells accounts for only 1 % of the tumor. The cells are embedded in a complex background of non-neoplastic immune infiltrates. Profound interactions ... -
HSP90-stabilized proteins as therapeutic targets in cancer
(2021-06-25)Although cancer is among the most common causes of death worldwide, successful treatment options for most cancer entities remain elusive, raising the need for novel therapies. One attractive target of current drug candidates ... -
Human induced pluripotent stem cell models used in the study of doxorubicin-induced cardiomyopathy
(2020-06-24)Doxorubicin (DOX) has been used for decades to treat hematopoietic and solid tumors, although, in a subset of cancer survivors, it causes cardiotoxicity decades after treatment. The mechanisms of anthracycline-induced ...