Dokumente Molekulare Medizin nach Titel
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Quantitative Proteomics Analysis of Global Protein Expression in Campylobacter jejuni Cultured in Sublethal Concentrations of Bile Acids and Varying Temperatures
(2017-07-06)Campylobacter jejuni is the leading cause of diarrhoea among human beings worldwide. Epidemiological investigations have shown that it affects over 500 million people per year. C. jejuni is mainly transmitted to human ... -
rAAV-based gene therapy for molybdenum cofactor deficiency type B
(2015-06-29)Molybdenum cofactor (MoCo) deficiency type A is thus far only one curable type of MoCo deficiency. In the present study, a mouse model for MoCo deficiency type B (Mocs2-/-) was generated, characterised and used for preclinical ... -
Real time cAMP dynamics in the vicinity of phospholemman in healthy and failing cardiomyocytes
(2016-08-16)The ubiquitous second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is a crucial regulator of cardiac function and disease. It is known that cAMP signaling is mediated by discrete functional microdomains each ... -
Real time visualization of cGMP and cAMP dynamics in intact adult cardiomyocytes using new transgenic mice
(2015-01-26)cAMP and cGMP are important second messengers in the cardiovascular system. Previously, it has been demonstrated that the cardiac ryanodine receptor (RyR2) forms a microdomain associated with key contributors of cAMP ... -
Redox regulation of protein phosphatase-1 and ER stress regulation of connective tissue growth factor in cardiomyocytes
(2017-06-28)Heart failure is one of the most common causes for morbidity and hospitalization in the western civilization. The prognosis is still poor and new therapies are needed. For decades, variations in phosphorylation and redox ... -
Redox regulation of ryanodine receptor/Ca2+ release channels by NOX enzymes in hypertrophy and heart failure
(2022-05-10)Cardiac function is characterized by a rhythmic sequence of contraction and relaxation of cardiomyocytes driven by tightly controlled intracellular calcium release events. The cardiac ryanodine receptor type 2 calcium ... -
Regional-dependent, comprehensive characterization of miRNA signatures in sporadic Creutzfeldt-Jakob Disease and early Alzheimer’s Disease-type neuropathology
(2019-10-09)The pathogenic mechanisms and the origins of neurodegenerative diseases remain unclear on molecular level. Increasing evidences postulate alterations in miRNA signatures as critical factor in pathogenesis, progression ... -
Regulation of lymphangiogenesis by WNT siganlling: Focus on WNT5A
(2019-02-05)Lymphangiogenesis – the development of lymphatic vessels – takes place in response to lymphangiogenic growth factors during embryogenesis, wound healing, inflammation and cancer. It has been shown that WNT signalling plays ... -
Regulation of Respiratory Chain Supercomplex Formation and the Involvement of Rcf-proteins
(2021-06-03)The mitochondrial oxidative phosphorylation machinery is comprised by five individual complexes and arranged in supramolecular structures, so-called supercomplexes, as it is shown for complex I, III, IV and V. In yeast S. ... -
Revisiting Erk signaling following B cell antigen receptor activation by different stimulatory agents
(2016-09-19)B cell antigen receptor (BCR) ligation leads to activation of a number of intracellular signaling events that decide the fate of the B cell and thus is a key event in humoral immunity. BCR activation is tightly controlled ... -
RhoGTPases and their relevance for the afterload-dependent myocardial fibrosis
(2016-12-06)The guanine exchange factor p63RhoGEF was identified as a specific activator of the RhoGTPase RhoA and its transcript was found to be abundant in brain and heart tissue. Amongst cardiac cells, the highest expression of ... -
RNA methylation in Cardiac Hypertrophy and Heart Failure
(2020-11-06)Cardiovascular diseases (CVDs) are the leading cause of hospital admission and mortality worldwide. Heart failure (HF) is one of the most common CVDs and is characterized by a reduced cardiac function and left ventricular ... -
Role of ASXL1 in Tumorigenesis and EMT in Breast Cancer
(2017-06-22)Breast cancer is one of the types of cancer that occurs in women frequently and most of the cancer deaths are due to metastasis. During cancer metastasis, the tumor epithelial cells lose their cell-cell contacts, acquire ... -
Role of MICOS for mitochondrial morphology and function
(2019-12-17)Mitochondria are highly dynamic organelles with a distinct morphological membrane ultrastructure. The mayor protein complex responsible for the formation and maintenance of the inner mitochondrial membrane is the ... -
Role of Pax6 in pancreatic endocrine cell subtype specification
(2014-03-27)Pax6, a transcription factor from the paired box gene family is expressed in the endocrine pancreas and is required for its proper development. As Pax6 classical and pancreas-specific conditional knockout mice die early ... -
Role of RAS signaling in Hedgehog-associated embryonal rhabdomyosarcoma
(2019-01-17)Rhabdomyosarcoma (RMS) are the most common pediatric soft tissue sarcomas. RMS of the embryonal subtype (ERMS) are characterized by high expression of markers of an activated Hedgehog (HH) signaling cascade, i.e. they ... -
Role of Secretory Processes in Cardiac Fibroblasts for Heart Failure Development and Progression
(2014-11-27)Cardiac fibroblasts play a major role in fibrogenesis associated with heart failure, since they produce ECM components and secrete important fibrosis-associated mediators, such as connective tissue growth factor (CTGF). ... -
Role of stromal SPARC in PDAC tumorigenesis and drug delivery
(2019-11-13)Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid tumors in humans. Median survival is around 12 months and is due to late diagnosis, early metastatic spread, and a high resistance towards available ... -
Die Rolle der Phosphodiesterase 2 im Herzen
(2014-12-03)Heart failure is a worldwide health issue with high morbidity and mortality rates and always a poor prognostic outlook. A characteristic element of the molecular driven structural transformation, which precedes the ... -
Seeding and structural varibility in α-synucleinopathies
(2019-06-12)In the present work, we were interested in applying the Real-time quaking-induced conversion (RT-QuIC) for the detection of the seeding activity of Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) brain derived ...