Dokumente Molekulare Medizin nach Titel
Anzeige 64-83 von 242
-
Effect of CLN3-loss-of-function on cellular metabolism and signalling
(2022-06-20)Since a coordinated function of all organelles is essential for the proper health of a eukaryotic cell, a defect in a single organelle can affect the condition of other organelles. For instance, mitochondrial dysfunction ... -
Effects of acute and long-term tachypacing on atrial engineered human myocardium
(2023-04-27)Atrial fibrillation is the most common supraventricular arrhythmia and is associated with molecular remodelling that promotes the maintenance and worsening of the disease. Although extensive research has been performed to ... -
Effects of dimethyl fumarate in two animal models of MS
(2017-04-25)MS is a heterogeneous disease characterized by transient and later permanent disability caused by inflammatory CNS lesions with profound axonal loss and demyelination. Although the exact pathogenesis of the disease is still ... -
Effects of histone 3.3K27M-mutation on CREB binding protein (CBP/p300)- and bromodomain and extra terminal domain (BET) protein- mediated gene regulation in diffuse intrinsic pontine gliomas (DIPG)
(2023-04-25)Diffuse intrinsic pontine gliomas (DIPG) are incurable pediatric high-grade tumors. The majority of all DIPG carries a mutation in one of the histone 3 genes leading to a substitution of lysine 27 to methionine (H3 K27M) ... -
Elucidating the pathomechanism behind the neurocristopathy CHARGE syndrome
(2018-02-26)CHARGE syndrome is a complex congenital malformation disorder, caused in more about two-thirds of the cases by heterozygous loss of function mutations in the chromodomain helicase DNA-binding protein 7 (CHD7). The acronym ... -
Emerging role of RNA-binding proteins in sporadic and rapid progressive Alzheimer’s disease
(2020-04-07)Alzheimer’s disease (AD) is the most prevalent cause of dementia. Typically, AD is characterized as a slow progressive dementia with an average disease duration of eight years. Recently, a rapidly progressive variant of ... -
Endothelial plasticity in fibrosis and epigenetics as a therapeutic target
(2021-11-26)In this thesis, we aim to (1) uncover novel (epi)genetic regulatory mechanisms that affect endothelial plasticity as an underlying cause of organ fibrosis, and (2) to therapeutically target (epi)genetic regulatory ... -
Endothelial Transformation Related Protein 53 Deletion Promotes Angiogenesis and Prevents Cardiac Fibrosis and Heart Failure Induced by Pressure Overload in Mice
(2015-01-21)Background− Accumulation of transformation related protein 53 (p53), apoptotic cell death and rarefication of myocardial angiogenesis may be involved in the development of cardiac dysfunction during chronic pressure ... -
Engineered skeletal muscle from human pluripotent stem cells to model muscle disease and regeneration
(2021-06-25)Skeletal muscle disease modeling offers the unique opportunity to investigate devastating muscle diseases like Duchenne Muscle Dystrophy in vitro but requires advanced three-dimensional (3D) model systems reflecting the ... -
Establishing and application of a syngeneic cerebral metastasis mouse model
(2015-06-02)Metastases are a major cause of morbidity and mortality in breast cancer patients. However, current treatments are of limited efficiency because so far very little is known about the colonisation of breast cancer cells ... -
Evaluation of synergistic hybrid nanoparticles for improved diagnosis and treatment of pancreatic cancer
(2023-09-13)Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis with no effective treatment options. Several factors contribute to its lethality, including the usually late diagnosis in the already advanced stage and ... -
Ex vivo und in vivo Modulation von Makrophagen und T-Zellen als therapeutisches Prinzip der aGvHD
(2015-10-15)Acute Graft-versus-Host disease (aGvHD) is a severe complication of hematopoietic stem cell transplantation. Glucocorticoids (GCs) are a mainstay of aGvHD therapy due to their potent anti-inflammatory and immunosuppressive ... -
Examining the interplay between oxidative and β-adrenergic regulation of PKARIα and its impact on the mitochondrial fission protein DRP1
(2017-07-03)PKA is activated by β-adrenergic signaling induced elevation in intracellular cAMP and sequestered into proximity with its substrates by scaffold A-kinase anchoring proteins (AKAPs). PKARIα is a unique isoform of PKA as ... -
Exosomes as Potential Transport Vehicles of Tetrahydrobiopterin, 6-Pyrovyoltetrahydrobiopterin-Synthase and Tripeptidyl-Peptidase I
(2018-12-14)Extracellular vesicles (EV) for the therapeutic application are of growing scientific interest. But even though the number of clinical trials on EVs almost doubled from 29 to 52 within 2017, the number of trials with ... -
Exploring molecular patterns and determinants of melanoma cell susceptibility to natural killer cell cytotoxicity
(2020-07-16)Malignant melanoma is the deadliest form of skin cancer. Due to its genetic heterogeneity and high potential to metastasize, the treatment of melanoma is challenging. Despite the promising result of T-cell based therapeutic ... -
Exploring the role of LZTR1 in an autosomal recessive form of Noonan Syndrome by genome-edited induced pluripotent stem cells
(2021-10-22)Noonan syndrome is a multisystemic developmental disorder and is characterized by variable symptoms such as facial dysmorphisms, short stature, webbing of the neck and mild intellectual disability. The most severe clinical ... -
Expression von Aufnahme-Transportern für Zytostatika in Mamma- und Prostatakarzinom-Zellen und ihre Interaktion mit Zytostatika
(2017-06-27)The solute carrier (SLC) transporters form a large family of membrane proteins that translocate dissolved substances across cell membranes. The first part of this work investigates the interaction of 26 commonly used ... -
Extracellular vesicles as mediators of intercellular communication in human breast cancer progression
(2014-10-17)The establishment of a permissive tumor microenvironment is a key step for tumor progression and metastasis formation. Tumor cells are known for their ability to create such a favorable tumor niche by influencing the ... -
EZH2-GATA6 axis in Pancreatic ductal adenocarcinoma
(2020-09-25)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease which is significantly driven by epigenetic alterations, e.g. installed by overexpression of Enhancer of Zeste homologue 2 (EZH2). EZH2 constitutes ... -
Fibroblast-Cardiomyocyte Cross-Talk in Heart Muscle Formation and Function
(2019-02-01)Cardiac fibroblasts make up a considerable fraction of the total heart cell content. How cardiac fibroblasts signaling affects heart muscle function in normal heart development and disease remains, however, largely unresolved. ...