Dokumente Molekulare Medizin nach Titel
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Uncovering triggers of colonization in brain metastasis
(2017-04-26)Brain metastases (BM) are frequent in cancer patients and are associated with poor prognosis. The incidence of BM is increasing mainly due to an improved control of primary tumors and an increased median survival of the ... -
Understanding Secretory MVB Trafficking for the Release of Small Extracellular Vesicles
(2021-04-16)The release of small extracellular vesicles (sEVs) from multivesicular bodies (MVBs) represents an integral part of intercellular communication during development, homeostasis and disease. While secretory MVBs are ... -
Unravelling epigenetic mechanisms of CAF-chemotherapy resistance in mammary carcinoma
(2020-01-29)Triple negative breast cancer (TNBC) is one of the most challenging cancers to treat as, despite the initial response to chemotherapy, relapse occurs frequently. In this project, we focused on the mechanisms that allow ... -
Untersuchungen zur Chemotherapieresistenz von H8N8-Tumorzellen nach Cyclophosphamid-, Doxorubicin- und 5-Fluouraciltherapie im syngenen WAP-T-Mammakarzinom-Mausmodell
(2019-10-18)In breast cancer patients, it is usually not the primary tumor that is the cause of death, but rather the development of locoregional or distant recurrence. Despite seemingly complete resection, some tumor cells often ... -
Using cell type-specific methods to understand molecular processes in the brain
(2019-05-17)Biological causes of many human diseases can be understood more comprehensively by measuring molecular states of the cells. Characterization of cells based on their inherent molecular profiles as well as functional changes ... -
WNT signalling affects cell migration, invasion and the lymphoma-endothelial interplay in Hodgkin Lymphoma
(2016-06-23)Classical Hodgkin Lymphoma (cHL) comprises a unique cancer where the microenvironment accounts for 99 % of the whole tumour mass. In cHL dissemination involves functionally neighbouring lymph nodes but the underlying ... -
Wnt-TCF7L2-dependent transcriptional and chromatin dynamics in cardiac regeneration, homeostasis and disease
(2018-11-12)Wnt/β-catenin-dependent signaling pathway is indispensible for cardiac development, becoming quiescent in the normal adult heart, and re-activated in both regenerative responses post-injury and in cardiac hypertrophy and ...