Dokumente Molekulare Medizin nach Titel
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Defining the Role of Chromatin Remodeling Complexes in Control of Master Transcription Factor Networks in Pancreatic Cancer Subtype Switch
(2023-10-19)Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous disease characterized by a dismal prognosis of 11%, projected to be the second-leading cause of cancer-related death by 2040. This urgent clinical challenge ... -
Development and evaluation of new approaches for fluorescence-guided surgery and therapy of pancreatic ductal adenocarcinoma using orthotopic mouse models
(2017-07-11)Pancreatic cancer has the poorest survival rate of the most common types of cancers with a 5 year survival rate of only 3-5% after diagnosis. Since there has been no significant improvement in the clinical outcome for ... -
Development of a genetically encoded model for the sensing of glutathione redox potential in human embryonic stem cell-derived cardiomyocytes and fibroblasts
(2017-05-29)Redox alterations due to increased ROS production in heart cells have been implicated in several cardiovascular diseases, such as ischemia, hypertrophy, and myocardial infarction, but may also play a crucial role for the ... -
Development of a Rhesus macaque engineered heart muscle model from pluripotent stem cells
(2017-06-13)Myocardial infarction is the leading cause of death globally. Remuscularization of the heart with stem cell based treatments is one potential approach to heart repair which is presently being tested. Proof-of-concept ... -
Differentiation-Induced Rearrangement of the Mitochondrial Calcium Uniporter Complex Regulates T-Cell-Mediated Immunity
(2023-01-20)CD4+ T-cells are an important cell type involved in proper mediation of the human adaptive immune system. Activation of CD4+ T-cells is a regulated process which includes a tightly controlled cytosolic calcium (Ca2+) ... -
Dissecting and Modeling Oncogene Dependent Molecular Mechanisms in Lymphoma Genesis and Progression
(2013-11-18)Aggressive Non-Hodgkin lymphomas (aNHL) are a heterogeneous group of lymphomas. The constellation of oncogenic pathway activities can vary in patients with the same malignant disease. The pathological mechanisms behind the ... -
Dissecting molecular elements of mitophagy and the lysis of intravacuolar vesicles
(2015-10-26)Autophagy is an evolutionary conserved catabolic process essential for the recycling and removal of cytosolic components via the lysosome (vacuole). Macroautophagy is characterized by the formation of a double membrane-layered ... -
Dissecting the molecular function of the ubiquitin-like Atg8 during autophagosome biogenesis in S. cerevisiae
(2018-03-23)Autophagy is a degradative pathway that is conserved from yeast to mammals. Marcoautophagy is characterized by the formation of a unique double-membrane layered vesicle, the so-called autophagosome. Proteins and organelles ... -
Dynamics of Neutrophil Extracellular Trap (NET) Formation
(2019-12-03)Neutrophil granulocytes are the largest group of white blood cells and play a significant role in the innate immune system. With the discovery of a vast number of thus far unknown functions, neutrophil granulocytes became ... -
Dynamics of the microbiome in pancreatic cancer from inception to invasion
(2023-10-23)Recently, the microbiome was associated with hallmark features of pancreatic ductal adenocarcinoma (PDAC). This dismal human disease with one of the lowest survival rates of below 10% is characterized by clinical challenges ... -
Dysferlin and its role in the pathogenesis of muscular dystrophy
(2013-11-21)Dysferlin is a multi C2 domain protein that belongs to the ferlin family and is localized to the T-tubule system in skeletal muscle fibers. It is involved in skeletal muscle membrane repair, regeneration and T-tubule ... -
Dysferlin in skeletal and heart muscle: from trafficking to therapy
(2017-09-19)Dysferlinopathies are a heterogeneous group of congenital muscle disorders characterized by late-onset muscular dystrophy and increased muscle prowess before onset of symptoms. Mutations in the DYSF gene encoding the protein ... -
Effect of CLN3-loss-of-function on cellular metabolism and signalling
(2022-06-20)Since a coordinated function of all organelles is essential for the proper health of a eukaryotic cell, a defect in a single organelle can affect the condition of other organelles. For instance, mitochondrial dysfunction ... -
Effects of acute and long-term tachypacing on atrial engineered human myocardium
(2023-04-27)Atrial fibrillation is the most common supraventricular arrhythmia and is associated with molecular remodelling that promotes the maintenance and worsening of the disease. Although extensive research has been performed to ... -
Effects of dimethyl fumarate in two animal models of MS
(2017-04-25)MS is a heterogeneous disease characterized by transient and later permanent disability caused by inflammatory CNS lesions with profound axonal loss and demyelination. Although the exact pathogenesis of the disease is still ... -
Effects of histone 3.3K27M-mutation on CREB binding protein (CBP/p300)- and bromodomain and extra terminal domain (BET) protein- mediated gene regulation in diffuse intrinsic pontine gliomas (DIPG)
(2023-04-25)Diffuse intrinsic pontine gliomas (DIPG) are incurable pediatric high-grade tumors. The majority of all DIPG carries a mutation in one of the histone 3 genes leading to a substitution of lysine 27 to methionine (H3 K27M) ... -
Elucidating the pathomechanism behind the neurocristopathy CHARGE syndrome
(2018-02-26)CHARGE syndrome is a complex congenital malformation disorder, caused in more about two-thirds of the cases by heterozygous loss of function mutations in the chromodomain helicase DNA-binding protein 7 (CHD7). The acronym ... -
Emerging role of RNA-binding proteins in sporadic and rapid progressive Alzheimer’s disease
(2020-04-07)Alzheimer’s disease (AD) is the most prevalent cause of dementia. Typically, AD is characterized as a slow progressive dementia with an average disease duration of eight years. Recently, a rapidly progressive variant of ... -
Endothelial plasticity in fibrosis and epigenetics as a therapeutic target
(2021-11-26)In this thesis, we aim to (1) uncover novel (epi)genetic regulatory mechanisms that affect endothelial plasticity as an underlying cause of organ fibrosis, and (2) to therapeutically target (epi)genetic regulatory ...