Dokumente Molekulare Medizin nach Titel
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New approaches to improve Extracorporeal Photopheresis for the treatment of Graft-versus-Host Disease
(2016-05-25)Graft-versus-host disease (GvHD) is a severe complication occurring after hematopoietic stem cell transplantation (HSCT). It is caused by alloreactive T cells contained in the graft, and associated with severe morbidity ... -
New Insights into Nucleophagy in S. cerevisiae
(2019-03-12)Nucleophagy is a specific type of autophagy, a process for the degradation of non-essential parts of the nucleus under starvation conditions. Nucleophagy can be subdivided into Atg39 and Atg40 dependent macronucleophagy ... -
Novel protein-protein interactions contribute to the regulation of cardiac excitation and Ca2+ handling
(2021-02-01)Cardiac function is defined by the process of excitation and contraction. During this process, the electrical excitation of the surface membrane is coupled to Ca2+-ion release at the sarcoplasmic reticulum, resulting in ... -
Novel therapeutic approaches for PDAC targeting potassium channels
(2023-12-07)Combining targeted and conventional therapies holds promise for the handling of challenging cancers. In this study, we propose the combination of the TNF-related apoptosis-inducing ligand (TRAIL) with Kv10.1-targeting ... -
Novel therapeutic approaches to treat inflammatory conditions with glucocorticoid and calciferol nanoparticles in vivo and in vitro
(2023-01-10)The body is constantly confronted with environmental threats and sometimes the entry of pathogens leads to severe inflammatory conditions such as sepsis or acute lung injury (ALI). Both diseases are characterized by a ... -
Nuclear NFATc1/Smad3 complexes in Smad4-deficient pancreatic cancer
(2019-12-17)Until today, pancreatic ductal adenocarcinoma (PDAC) is characterized by its extremely high mortality rate and the lack of effective treatment strategies despite reinforced focus on the elucidation of underlying molecular ... -
Off the beaten path - An unbiased inventory of signal response elements in B cell receptor signaling
(2021-04-06)Signaling through the B cell antigen receptor (BCR) is indispensable for B lymphocyte maturation, activation and differentiation. Antigenic signal transduction thus constitutes a centerpiece of adaptive immunity and its ... -
Optimization of the RT-QuIC in prion disease diagnostic
(2023-01-11)In the present work, we were interested in applying different recombinant prion proteins (rec PrP) as substrates in the real-time quaking-induced conversion (RT-QuIC) assay to improve the diagnostic accuracy in different ... -
Organization and consequences of functional responses in microglia upon activation of the TLR4 complex
(2014-09-30)Microglia are resident macrophage-like cells of the central nervous system (CNS) which constantly survey the tissue for signs of homeostatic disturbance. As the major immunocompetent effector cells in the brain parenchyma, ... -
Overcoming Cisplatin Resistance in Pancreatic Cancer
(2021-11-16)Pancreatic ductal adenocarcinoma (PDAC) is the most common species of pancreatic cancer with high lethality. Despite intensive research, no major therapy improvements have been achieved due to late-stage diagnosis and ... -
Peroxisomal calcium handling and homeostasis
(2022-04-26)Peroxisomes are ubiquitous cellular organelles in eukaryotes essential for metabolism. The close localization of peroxisomes with the sarcoplasmic reticulum and T-tubules is known from electron micrographs of rodent hearts. ... -
Phosphodiesterases as Crucial Regulators of Cardiomyocyte cAMP in Health and Disease
(2014-11-13)Cyclic nucleotides are ubiquitous second messengers, which regulate cellular functions by acting in discrete subcellular microdomains. Cardiac phosphodiesterases (PDEs) are indispensable for -adrenoceptor signaling regulation ... -
Phospholamban - Identification of novel interaction partners
(2020-07-24)Cardiac contraction and relaxation depend on intracellular Ca2+ release and sequestration in the sarcoplasmic reticulum (SR). The small tail-anchored protein phospholamban (PLN) is essential for normal stress-adaptation ... -
Physiological and molecular features of glucocorticoid actions in the gastrointestinal tract
(2015-04-14)Ever since their first successful application in the treatment of RA patients in the late 1950, GCs have been the gold standard for the treatment of multiple inflammatory and neoplastic diseases. There are, however, also ... -
Physiology, metabolism and redox mechanisms in chronic cardiac volume overload
(2016-11-04)Chronic haemodynamic stress in the heart, induced by volume or pressure overload, contributes to cardiac dysfunction and heart failure and is associated with several human cardiovascular diseases (e.g. valvular heart ... -
Pre-Clinical Assessment of Cardiac and Lung Fibrosis Using Next Generation Imaging Modalities
(2022-03-08)Fibrosis, defined as an excessive deposition of connective tissue components causing disruption of the physiological architecture and organ malfunction, is commonly associated with high morbidity and mortality. The global ... -
Proinflammatory CD20+ T cells: Their origin and therapeutic depletion in CNS-directed autoimmunity
(2021-04-06)Anti-CD20 antibody (ab) treatment exhibits an unprecedented therapeutic benefit in multiple sclerosis (MS). The very fact that B cell depletion is effective in a disease that was generally considered T cell-driven was ... -
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions
(2014-07-14)On molecular level, cells sense changes in oxygen availability through the prolyl-4-hydroxylase domain enzymes (PHDs), which in turn regulate the protein stability of the α-subunit of the transcription factor hypoxia-inducible ... -
Quantitative Proteomics Analysis of Global Protein Expression in Campylobacter jejuni Cultured in Sublethal Concentrations of Bile Acids and Varying Temperatures
(2017-07-06)Campylobacter jejuni is the leading cause of diarrhoea among human beings worldwide. Epidemiological investigations have shown that it affects over 500 million people per year. C. jejuni is mainly transmitted to human ... -
rAAV-based gene therapy for molybdenum cofactor deficiency type B
(2015-06-29)Molybdenum cofactor (MoCo) deficiency type A is thus far only one curable type of MoCo deficiency. In the present study, a mouse model for MoCo deficiency type B (Mocs2-/-) was generated, characterised and used for preclinical ...