Dokumente Molekulare Medizin nach Titel
Anzeige 158-177 von 242
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Off the beaten path - An unbiased inventory of signal response elements in B cell receptor signaling
(2021-04-06)Signaling through the B cell antigen receptor (BCR) is indispensable for B lymphocyte maturation, activation and differentiation. Antigenic signal transduction thus constitutes a centerpiece of adaptive immunity and its ... -
Optimization of the RT-QuIC in prion disease diagnostic
(2023-01-11)In the present work, we were interested in applying different recombinant prion proteins (rec PrP) as substrates in the real-time quaking-induced conversion (RT-QuIC) assay to improve the diagnostic accuracy in different ... -
Organization and consequences of functional responses in microglia upon activation of the TLR4 complex
(2014-09-30)Microglia are resident macrophage-like cells of the central nervous system (CNS) which constantly survey the tissue for signs of homeostatic disturbance. As the major immunocompetent effector cells in the brain parenchyma, ... -
Overcoming Cisplatin Resistance in Pancreatic Cancer
(2021-11-16)Pancreatic ductal adenocarcinoma (PDAC) is the most common species of pancreatic cancer with high lethality. Despite intensive research, no major therapy improvements have been achieved due to late-stage diagnosis and ... -
Peroxisomal calcium handling and homeostasis
(2022-04-26)Peroxisomes are ubiquitous cellular organelles in eukaryotes essential for metabolism. The close localization of peroxisomes with the sarcoplasmic reticulum and T-tubules is known from electron micrographs of rodent hearts. ... -
Phosphodiesterases as Crucial Regulators of Cardiomyocyte cAMP in Health and Disease
(2014-11-13)Cyclic nucleotides are ubiquitous second messengers, which regulate cellular functions by acting in discrete subcellular microdomains. Cardiac phosphodiesterases (PDEs) are indispensable for -adrenoceptor signaling regulation ... -
Phospholamban - Identification of novel interaction partners
(2020-07-24)Cardiac contraction and relaxation depend on intracellular Ca2+ release and sequestration in the sarcoplasmic reticulum (SR). The small tail-anchored protein phospholamban (PLN) is essential for normal stress-adaptation ... -
Physiological and molecular features of glucocorticoid actions in the gastrointestinal tract
(2015-04-14)Ever since their first successful application in the treatment of RA patients in the late 1950, GCs have been the gold standard for the treatment of multiple inflammatory and neoplastic diseases. There are, however, also ... -
Physiology, metabolism and redox mechanisms in chronic cardiac volume overload
(2016-11-04)Chronic haemodynamic stress in the heart, induced by volume or pressure overload, contributes to cardiac dysfunction and heart failure and is associated with several human cardiovascular diseases (e.g. valvular heart ... -
Pre-Clinical Assessment of Cardiac and Lung Fibrosis Using Next Generation Imaging Modalities
(2022-03-08)Fibrosis, defined as an excessive deposition of connective tissue components causing disruption of the physiological architecture and organ malfunction, is commonly associated with high morbidity and mortality. The global ... -
Proinflammatory CD20+ T cells: Their origin and therapeutic depletion in CNS-directed autoimmunity
(2021-04-06)Anti-CD20 antibody (ab) treatment exhibits an unprecedented therapeutic benefit in multiple sclerosis (MS). The very fact that B cell depletion is effective in a disease that was generally considered T cell-driven was ... -
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions
(2014-07-14)On molecular level, cells sense changes in oxygen availability through the prolyl-4-hydroxylase domain enzymes (PHDs), which in turn regulate the protein stability of the α-subunit of the transcription factor hypoxia-inducible ... -
Quantitative Proteomics Analysis of Global Protein Expression in Campylobacter jejuni Cultured in Sublethal Concentrations of Bile Acids and Varying Temperatures
(2017-07-06)Campylobacter jejuni is the leading cause of diarrhoea among human beings worldwide. Epidemiological investigations have shown that it affects over 500 million people per year. C. jejuni is mainly transmitted to human ... -
rAAV-based gene therapy for molybdenum cofactor deficiency type B
(2015-06-29)Molybdenum cofactor (MoCo) deficiency type A is thus far only one curable type of MoCo deficiency. In the present study, a mouse model for MoCo deficiency type B (Mocs2-/-) was generated, characterised and used for preclinical ... -
Real time cAMP dynamics in the vicinity of phospholemman in healthy and failing cardiomyocytes
(2016-08-16)The ubiquitous second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is a crucial regulator of cardiac function and disease. It is known that cAMP signaling is mediated by discrete functional microdomains each ... -
Real time visualization of cGMP and cAMP dynamics in intact adult cardiomyocytes using new transgenic mice
(2015-01-26)cAMP and cGMP are important second messengers in the cardiovascular system. Previously, it has been demonstrated that the cardiac ryanodine receptor (RyR2) forms a microdomain associated with key contributors of cAMP ... -
Redox regulation of protein phosphatase-1 and ER stress regulation of connective tissue growth factor in cardiomyocytes
(2017-06-28)Heart failure is one of the most common causes for morbidity and hospitalization in the western civilization. The prognosis is still poor and new therapies are needed. For decades, variations in phosphorylation and redox ... -
Redox regulation of ryanodine receptor/Ca2+ release channels by NOX enzymes in hypertrophy and heart failure
(2022-05-10)Cardiac function is characterized by a rhythmic sequence of contraction and relaxation of cardiomyocytes driven by tightly controlled intracellular calcium release events. The cardiac ryanodine receptor type 2 calcium ... -
Regional-dependent, comprehensive characterization of miRNA signatures in sporadic Creutzfeldt-Jakob Disease and early Alzheimer’s Disease-type neuropathology
(2019-10-09)The pathogenic mechanisms and the origins of neurodegenerative diseases remain unclear on molecular level. Increasing evidences postulate alterations in miRNA signatures as critical factor in pathogenesis, progression ... -
Regulation of lymphangiogenesis by WNT siganlling: Focus on WNT5A
(2019-02-05)Lymphangiogenesis – the development of lymphatic vessels – takes place in response to lymphangiogenic growth factors during embryogenesis, wound healing, inflammation and cancer. It has been shown that WNT signalling plays ...