Dokumente Molekulare Medizin nach Titel
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Seeding and structural varibility in α-synucleinopathies
(2019-06-12)In the present work, we were interested in applying the Real-time quaking-induced conversion (RT-QuIC) for the detection of the seeding activity of Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) brain derived ... -
Spatial Architecture and Functional Characterization of Super Enhancer Associated Transcriptional Circuits in Aggressive Lymphomas
(2023-10-19)Aggressive lymphomas are clinically and biologically heterogenous entities, reflecting a diverse cell of-origins with multiple means of malignant transformation. With chemoimmunotherapy, a majority of patients suffering ... -
Stereoselectivity in Drug Membrane Transport by Solute Carriers (SLCs)
(2023-07-10)About 50% of all small molecule drugs are racemic mixtures of usually two stereoisomers. In the living organism, these drugs interact with a mostly chiral environment of unichiral amino acids, sugars, hormones, and other ... -
Stromal and epithelial mechanisms of chemotherapeutic resistance in pancreatic cancer
(2019-05-24)Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of less than 8 %. Hallmarks of pancreatic cancer are extensive desmoplasia and strong resistance to standard chemotherapeutic ... -
Structure and molecular function of WD-40 repeat-containing autophagy proteins Atg18, Atg21 and Hsv2
(2022-06-23)Autophagy is a highly regulated cellular degradation and recycling process conserved from yeast to higher eukaryotes. This process is constitutively active at a low level, and non-selectively degrades portions of the cytosol ... -
Studying the Interactions of Cytotoxic T Cells with Neurons in vivo
(2013-12-13)The central nervous system (CNS) is considered as largely isolated from the immune system – a status referred to as “immune privilege”. But CNS-tissue is constantly surveyed by immune cells and can under certain circumstances, ... -
Studying the role of coenzyme Q10 in mitochondrial calcium and redox signaling
(2022-06-30)Mitochondria can take up large amounts of calcium (Ca2+) in order to control the activity of several enzymes and their bioenergetics output. As a consequence of this metabolic flux, reactive oxygen species (ROS) are generated ... -
Synergism of IL10R and TLR9 signaling affects gene expression, proliferation and metabolism in B cells: A comparative study of STAT3/NF-kB and c-Myc mediated effects
(2016-10-11)The interplay of different signaling pathways activated by factors of the cellular environment and expression the proto-oncogene c-Myc (MYC) defines B cell fate in the germinal center (GC). Importantly, the same signaling ... -
Targeting and Elimination of T Cell Subpopulations by Chimeric Antigen Receptor-modified T Cells
(2021-08-10)Chimeric antigen receptors (CARs) demonstrated a high potential for the elimination of tumor cells in cancer immunotherapy. The first successful application of CAR-expressing T cells aimed at the elimination of B cells in ... -
Targeting cell invason signaling to impede breast cancer metastasis
(2020-02-25)Breast cancer cell invasion is the initial step of the invasion-metastatic cascade, and approximately 90 % of all cancer-related deaths are due to currently incurable cancer metastasis (1). Unique features of tumor ... -
Targeting JAK/STAT signalling for sensitization of colorectal cancer cells to chemoradiotherapy
(2021-07-08)Despite ever-evolving treatment and screening procedures, Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide. Preoperative chemoradiotherapy (CRT), followed by standardized surgical resection ... -
Targeting MDM2, the antagonist of the tumor suppressor p53
(2018-09-19)p53 is one of the most extensively studied tumor suppressor proteins, and its gene is mutated in 50% of human cancers. Stress signals activate p53 and its transcriptional machinery which lead to cell-cycle arrest, apoptosis ... -
Targeting the Hedgehog and PI3K/AKT/mTOR signaling pathways in rhabdomyosarcoma
(2018-12-18)Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS, and especially the embryonal subtype (ERMS), show activation of Hedgehog (HH) signaling. In patients with Gorlin syndrome, ... -
TET3 IMPACTS CARDIAC FIBROSIS PARTIALLY VIA REGULATION OF DNA DAMAGE RESPONSE
(2020-02-12)Activation and proliferation of cardiac fibroblasts are the prime mediators of cardiac fibrosis. Existing studies show that ROS and inflammatory cytokines produced during fibrosis not only signal proliferative stimuli but ... -
TGFβ mediated chromosomal instability in human colorectal cancer cells
(2023-06-28)Chromosomal instability (CIN) is a major hallmark of human cancer and is defined as persistently high rate of the generation of chromosomal aberrations leading to genetic variability, tumour heterogeneity and tumour ... -
The Development of Premortal Diagnostic Test for a-Synucleinopathies in Cerebrospinal Fluid and Blood
(2024-01-26)Synucleinopathies represent a group of neurodegenerative disorders characterized by the accumulation of abnormal α-synuclein protein aggregates in the central nervous system. Accurate and early diagnosis is crucial for ... -
The Endogenous and Exogenous Substrate Spectrum of the Human Organic Cation Transporter OCT1 – a Comprehensive Characterization
(2021-07-23)The organic cation transporter 1 (OCT1) is most extensively expressed in the human liver. OCT1 is involved in the hepatic uptake of several drugs and endogenous compounds, which then undergo bioactivation, recycling, ... -
The histone methyltransferase DOT1L is required for DNA damage recognition and repair
(2017-02-02)New effective combinational therapeutic strategies are an alternative choice for a successful translational study. Disruptor of telomeric silencing 1-like (DOT1L) is a histone 3 lysine 79 (H3K79) methyltransferase enzyme ... -
The importance of homotypic interactions of unphosphorylated STAT proteins in cytokine-induced signal transduction
(2021-03-12)Several cytokines mediate cellular responses via the family of transcription factors called signal transducers and activators of transcription (STAT). Though phosphorylated STATs (P-STAT) form the active and extensively ... -
The influence of valproic acid and the role of cyclin D2 in prostate cancer
(2016-10-11)Prostate cancer (PCa) is the most frequently new diagnosed cancer and the third leading cause of cancer-related deaths in men in Germany. Studies on possible agents for PCa therapy are indispensable since treatment options ...