Dokumente Molekulare Medizin nach Titel
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Targeting and Elimination of T Cell Subpopulations by Chimeric Antigen Receptor-modified T Cells
(2021-08-10)Chimeric antigen receptors (CARs) demonstrated a high potential for the elimination of tumor cells in cancer immunotherapy. The first successful application of CAR-expressing T cells aimed at the elimination of B cells in ... -
Targeting cell invason signaling to impede breast cancer metastasis
(2020-02-25)Breast cancer cell invasion is the initial step of the invasion-metastatic cascade, and approximately 90 % of all cancer-related deaths are due to currently incurable cancer metastasis (1). Unique features of tumor ... -
Targeting JAK/STAT signalling for sensitization of colorectal cancer cells to chemoradiotherapy
(2021-07-08)Despite ever-evolving treatment and screening procedures, Colorectal cancer (CRC) remains a major cause of cancer-related deaths worldwide. Preoperative chemoradiotherapy (CRT), followed by standardized surgical resection ... -
Targeting MDM2, the antagonist of the tumor suppressor p53
(2018-09-19)p53 is one of the most extensively studied tumor suppressor proteins, and its gene is mutated in 50% of human cancers. Stress signals activate p53 and its transcriptional machinery which lead to cell-cycle arrest, apoptosis ... -
Targeting the Hedgehog and PI3K/AKT/mTOR signaling pathways in rhabdomyosarcoma
(2018-12-18)Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS, and especially the embryonal subtype (ERMS), show activation of Hedgehog (HH) signaling. In patients with Gorlin syndrome, ... -
TET3 IMPACTS CARDIAC FIBROSIS PARTIALLY VIA REGULATION OF DNA DAMAGE RESPONSE
(2020-02-12)Activation and proliferation of cardiac fibroblasts are the prime mediators of cardiac fibrosis. Existing studies show that ROS and inflammatory cytokines produced during fibrosis not only signal proliferative stimuli but ... -
TGFβ mediated chromosomal instability in human colorectal cancer cells
(2023-06-28)Chromosomal instability (CIN) is a major hallmark of human cancer and is defined as persistently high rate of the generation of chromosomal aberrations leading to genetic variability, tumour heterogeneity and tumour ... -
The Development of Premortal Diagnostic Test for a-Synucleinopathies in Cerebrospinal Fluid and Blood
(2024-01-26)Synucleinopathies represent a group of neurodegenerative disorders characterized by the accumulation of abnormal α-synuclein protein aggregates in the central nervous system. Accurate and early diagnosis is crucial for ... -
The Endogenous and Exogenous Substrate Spectrum of the Human Organic Cation Transporter OCT1 – a Comprehensive Characterization
(2021-07-23)The organic cation transporter 1 (OCT1) is most extensively expressed in the human liver. OCT1 is involved in the hepatic uptake of several drugs and endogenous compounds, which then undergo bioactivation, recycling, ... -
The histone methyltransferase DOT1L is required for DNA damage recognition and repair
(2017-02-02)New effective combinational therapeutic strategies are an alternative choice for a successful translational study. Disruptor of telomeric silencing 1-like (DOT1L) is a histone 3 lysine 79 (H3K79) methyltransferase enzyme ... -
The importance of homotypic interactions of unphosphorylated STAT proteins in cytokine-induced signal transduction
(2021-03-12)Several cytokines mediate cellular responses via the family of transcription factors called signal transducers and activators of transcription (STAT). Though phosphorylated STATs (P-STAT) form the active and extensively ... -
The influence of valproic acid and the role of cyclin D2 in prostate cancer
(2016-10-11)Prostate cancer (PCa) is the most frequently new diagnosed cancer and the third leading cause of cancer-related deaths in men in Germany. Studies on possible agents for PCa therapy are indispensable since treatment options ... -
The interaction between Hedgehog/Patched and Ras signaling in Rhabdomyosarcoma
(2016-03-15)Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. In children, the most common histological subtypes are embryonal RMS (ERMS) and alveolar RMS (ARMS). One feature of human RMS is aberrant Hedgehog ... -
The Kv10.1 voltage gated potassium ion channel modulates the cell adhesion and cell migration hallmarks of cancer
(2015-06-23)A characteristic of the Kv10.1 voltage-gated potassium ion channel is its overexpression in a number of cancerous tissues and cancer cell lines, even though it should normally be restricted to the adult brain and myoblasts. ... -
The MDM2 oncoprotein antagonizes Poly(ADP-ribosyl)ation
(2023-02-23)MDM2 is a target gene product and a negative regulator of the tumor suppressor p53. Additionally, MDM2 interferes with the progression of DNA replication forks. Poly(ADP-Ribose) Polymerase 1 (PARP1) is the main ... -
The oxygen sensor PHD2 affects energy metabolism and cell function in macrophages
(2016-11-08)Macrophages are key players in the innate immune system and contribute significantly to inflammation in ischemic tissues, such as the infarcted heart. During inflammation, macrophages are involved in tissue remodeling, ... -
The role of amyloid beta 4-42 in the etiology of Alzheimer's disease
(2015-01-06)N-truncated Aβ4-42 has been identified as a particular abundant Aβ species in the hippocampus and cortex of Alzheimer's patients. However, relatively little is known about the contribution of Aβ4-42 to the development and ... -
The role of astrocytes in murine models of toxic demyelination
(2016-08-30)In demyelinating diseases such as multiple sclerosis (MS) activated astrocytes, characterised by up-regulation of the intermediate filament glial fibrillary acidic protein (GFAP), were shown to have beneficial as well as ... -
The role of astrocytic RFX4_v3 in demyelination
(2015-05-11)RFX4_v3 is the brain-specific splice variant of the transcription factor RFX4 (Blackshear et al., 2003; Matsushita et al., 2005). It was shown to play an important role during early brain development and in the genesis of ... -
The role of Ca2+ influx mechanisms in the regulation of human cardiac fibroblasts in 2D- and 3D- culture models
(2021-06-24)Cardiac fibrosis is a serious health problem commonly associated with cardiovascular diseases and remains an increasing health burden around the globe. The development of cardiac fibrosis involves the activation and ...